N.N'-bis-benzyloxycarbonyl-L-cystyl dichloride | 40470-28-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N.N'-bis-benzyloxycarbonyl-L-cystyl dichloride
• 英文别名: N.N'-Bis-benzyloxycarbonyl-L-cystyldichlorid
• CAS: 40470-28-8
• 化学式: C₂₂H₂₂Cl₂N₂O₆S₂
• 分子量: 545.464
• InChiKey: APTZVBIHSBCXHJ-ROUUACIJSA-N

物化性质

• 沸点：
  694.5±55.0 °C(Predicted)
• 密度：
  1.415±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.49
• 重原子数：
  34.0
• 可旋转键数：
  13.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  110.8
• 氢给体数：
  2.0
• 氢受体数：
  8.0

反应信息

• 作为反应物：
  描述：

  N.N'-bis-benzyloxycarbonyl-L-cystyl dichloride 在 sodium acetate 作用下， 以 乙醚 、 水 为溶剂， 反应 7.0h， 生成 N,N'-dibenzoyl-L-cystine di(dimethylamide)
  参考文献：
  名称：

  Anatomy of a Gel. Amino Acid Derivatives That Rigidify Water at Submillimolar Concentrations

  摘要：

  On the basis of suggestive X-ray data, 14 aroyl L-cystine derivatives were designed, synthesized, and examined for their ability to gelate water. Several members of this amino acid family are remarkably effective aqueous gelators (the best being one that can rigidify aqueous solutions at 0.25 mM, ca. 0.01%, in less than 30 s!). A few of the analogues separate from water as crystals, indicating a close relationship between gelation and crystallization. All effective gelators self-assemble into fibrous structures that entrain the solvent in the capillary spaces among them. Hydrogen-bonding sites on the compounds that might stabilize the fibers were identified from specific substitutions that replace a hydrogen donor with a methyl group, enhance the hydrogen-accepting ability of a carbonyl oxygen, or promote the hydrogen-donating, ability of an amide proton. The structural variations were characterized via minimal gelation concentrations and times, X-ray crystallography, light and electron microscopy, rheology, and calorimetry. The multiple techniques, applied to the diverse compounds, allowed an extensive search into the basis of gelation. It was learned, for example, that the compound with the lowest minimum gelator concentration and time also has one of the weakest gels (i.e., it has a low elastic modulus). This is attributed to kinetic effects that perturb the length of the fibers. It was also argued that pi/pi stacking, the carboxyl carbonyl (but not the carboxyl proton), and solubility factors all contribute to the stability of a fiber. Polymorphism also plays a role. Rheological studies at different temperatures show that certain gels are stable to a 1-Hz, 3-Pa oscillating shear stress at temperatures as high as 90 degreesC. Other gels have a "catastrophic" break at lower temperatures. Calorimetric data indicate a smooth transition from gel to sol as the temperature is increased. These and other issues are discussed in this "anatomy" of a gel.

  DOI：

  10.1021/ja0016811
• 作为产物：
  描述：

  L-胱氨酸 在 sodium hydroxide 、 乙醚 、 五氯化磷 作用下， 生成 N.N'-bis-benzyloxycarbonyl-L-cystyl dichloride
  参考文献：
  名称：

  Bergmann; Zervas, Chemische Berichte, 1932, vol. 65, p. 1192,1198

  摘要：

  DOI：

文献信息

• ProbeMatchDB—a web database for finding equivalent probes across microarray platforms and species
  作者：Pinglang Wang、Fei Ding、Hsienyuan Chiang、Robert C. Thompson、Stanley J. Watson、Fan Meng

  DOI：10.1093/bioinformatics/18.3.488

  日期：2002.3.1

  Summary: ProbeMatchDB is a web-based database designed to facilitate the search of EST/cDNA sequences or STS markers that can be used to represent the same gene across different microarray platforms and species. It can be used for finding equivalent EST clones in the Research Genetics sequence verified clone set based on results from Affymetirx GeneChip®s. It will also help to identify probes representing orthologous genes across human, mouse and rat on different microarray platforms.

  Availability: The database is accessible at http://brainarray.mhri.med.umich.edu/MARRAY/BC_ASP/brainarray.htm by clicking the ‘Query ProbeMatchDB’ link.

  Contact: [e-mail]

  摘要：ProbeMAtchDB是一个基于网络的数据库，旨在促进对EST/cDNA序列或STS标记的搜索，这些序列或标记可用于代表不同微阵列平台和物种中相同基因。它可用于根据Affymetirx GeneChip®s的结果在Research Genetics序列验证的克隆集中查找等价的EST克隆。它还将有助于识别在不同微阵列平台上代表人类、小鼠和大鼠同源基因的探针。 可用性：该数据库可通过点击“查询ProbeMAtchDB”链接访问http://bRAinarRAy.mhri.med.umich.edu/MARRAY/BC_ASP/bRAinarRAy.htm。 联系人：[e-mail]
• GeneANOVA—gene expression analysis of variance
  作者：G. Didier、P. Brézellec、E. Remy、A. Hénaut

  DOI：10.1093/bioinformatics/18.3.490

  日期：2002.3.1

  Summary: GeneANOVA is an ANOVA-based software devoted to the analysis of gene expression data.

  Availability: GeneANOVA is freely available on request for non-commercial use.

  Contact: [e-mail]

  摘要：GeneANOVA是一款基于ANOVA的软件，专门用于分析基因表达数据。

  可用性：GeneANOVA可根据要求免费提供给非商业用户使用。

  联系方式：[e-mail]

• Synthesis and reactions of α-thioformyl dipeptides, possible biogenetic precursors of penicillin
  作者：John Cheney、Clive J. Moores、James A. Raleigh、A. Ian Scott、Douglas W. Young

  DOI：10.1039/p19740000986

  日期：——

  Thioformyl dipeptides (II) have been synthesised by various routes and the existence of these unstable compounds has been verified by trapping experiments. At room temperature the thioaldehydes polymerise readily and at lower temperatures the thioenol forms are stabilised. When thioenolisation is prevented by the presence of an α-methyl substituent as in (XX), polymerisation is the only observable

  硫代甲酰基二肽（II）已经通过各种途径合成，并且这些不稳定的化合物的存在已经通过捕获实验得到证实。在室温下，硫醛容易聚合，而在较低温度下，硫烯醇形式稳定。如（XX）中所述，当通过α-甲基取代基的存在阻止硫烯醇化时，聚合是唯一可观察到的反应。尚未观察到以制备规模环化为β-内酰胺衍生物。
• Harington; Mead, Biochemical Journal, 1935, vol. 29, p. 1602,1605
  作者：Harington、Mead

  DOI：——

  日期：——
• du Vigneaud; Miller, Biochemical Preparations, 1952, vol. 2, p. 74,75
  作者：du Vigneaud、Miller

  DOI：——

  日期：——