(2S,αS)-1-(α-carbamoyl-α-(4-chlorophenyl)methyl)-pyrrolidine-2-carboxylic acid methyl ester | 1397680-04-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (2S,αS)-1-(α-carbamoyl-α-(4-chlorophenyl)methyl)-pyrrolidine-2-carboxylic acid methyl ester
• 英文别名: methyl (2S)-1-[(1S)-2-amino-1-(4-chlorophenyl)-2-oxoethyl]pyrrolidine-2-carboxylate
• CAS: 1397680-04-4
• 化学式: C₁₄H₁₇ClN₂O₃
• 分子量: 296.754
• InChiKey: ALOIXAZEIWSSPZ-RYUDHWBXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  20
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  72.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (2S,αS)-1-(α-carbamoyl-α-(4-chlorophenyl)methyl)-pyrrolidine-2-carboxylic acid methyl ester 在 sodium hydroxide 作用下， 以 乙醇 为溶剂， 以72%的产率得到(4S,8aS)-4-(4-chlorophenyl)-perhydropyrrolo[1,2-a]pyrazine-1,3-dione
  参考文献：
  名称：

  Synthesis of bicyclic 2,6-diketopiperazines via a three-step sequence involving an Ugi five-center, four-component reaction

  摘要：

  A three-step sequence involving an Ugi five-center, four-component reaction (U-5C-4CR), amide N-detertbutylation and cyclocondensation has been developed for easy access to diverse bicyclic 2,6-diketopiperazine (2,6-DKP) derivatives. In the key step, aromatic aldehydes were successfully coupled with cyclic alpha-amino acids and isocyanides in the course of U-5C-4CR. Boron trifluoride-acetic acid complex was developed as a new N-detertbutylating agent effective at rt. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2012.07.064
• 作为产物：
  描述：

  (2S,αS)-1-(1-tert-butyl-carbamoyl-1-(4-chlorophenyl)methyl)-pyrrolidine-2-carboxylic acid methyl ester 在 boron trifluoride diacetate 作用下， 以74%的产率得到(2S,αS)-1-(α-carbamoyl-α-(4-chlorophenyl)methyl)-pyrrolidine-2-carboxylic acid methyl ester
  参考文献：
  名称：

  Synthesis of bicyclic 2,6-diketopiperazines via a three-step sequence involving an Ugi five-center, four-component reaction

  摘要：

  A three-step sequence involving an Ugi five-center, four-component reaction (U-5C-4CR), amide N-detertbutylation and cyclocondensation has been developed for easy access to diverse bicyclic 2,6-diketopiperazine (2,6-DKP) derivatives. In the key step, aromatic aldehydes were successfully coupled with cyclic alpha-amino acids and isocyanides in the course of U-5C-4CR. Boron trifluoride-acetic acid complex was developed as a new N-detertbutylating agent effective at rt. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2012.07.064

文献信息

• Synthesis of bicyclic 2,6-diketopiperazines via a three-step sequence involving an Ugi five-center, four-component reaction
  作者：Maciej Dawidowski、Franciszek Herold、Marcin Wilczek、Jadwiga Turło、Andrzej Chodkowski、Anna Gomółka、Jerzy Kleps

  DOI：10.1016/j.tet.2012.07.064

  日期：2012.9

  A three-step sequence involving an Ugi five-center, four-component reaction (U-5C-4CR), amide N-detertbutylation and cyclocondensation has been developed for easy access to diverse bicyclic 2,6-diketopiperazine (2,6-DKP) derivatives. In the key step, aromatic aldehydes were successfully coupled with cyclic alpha-amino acids and isocyanides in the course of U-5C-4CR. Boron trifluoride-acetic acid complex was developed as a new N-detertbutylating agent effective at rt. (C) 2012 Elsevier Ltd. All rights reserved.