optically inactive 2,3-dineopentyl-succinic acid diethyl ester | 31038-86-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: optically inactive 2,3-dineopentyl-succinic acid diethyl ester
• 英文别名: Opt.-inakt. 2,3-Dineopentyl-bernsteinsaeure-diaethylester；Diethyl 2,3-bis(2,2-dimethylpropyl)butanedioate
• CAS: 31038-86-5
• 化学式: C₁₈H₃₄O₄
• 分子量: 314.466
• InChiKey: YCYHZGIPKZHEEL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  22
• 可旋转键数：
  11
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  optically inactive 2,3-dineopentyl-succinic acid diethyl ester 在 氢氧化钾 作用下， 生成 meso-2,3-dineopentyl-succinic acid 、 racem.-2,3-dineopentyl-succinic acid
  参考文献：
  名称：

  Benzodiazepines and anterior pituitary function

  摘要：

  Benzodiazepines (BDZ) are one of the most prescribed classes of drugs because of their marked anxiolytic, anticonvulsant, muscle relaxant and hypnotic effects. The pharmacological actions of BDZ depend on the activation of 2 specific receptors. The central BDZ receptor, present in several areas of the central nervous system (CNS), is a component of the GABA-A receptor, the activation of which increases GABAergic neurotransmission and is followed by remarkable neuroendocrine effects. The peripheral benzodiazepine receptors (PBR), structurally and functionally different from the GABA-A receptor, have been shown in peripheral tissues but also in the CNS, in both neurones and glial cells, and in the pituitary gland. BDZ receptors bind to a family of natural peptides called endozepines, firstly isolated from neurons and glial cells in the brain and then in several peripheral tissues as well. Endozelpines modulate several central and peripheral biological activities, including some neuroendocrine functions and synthetic BDZ are likely to mimic them, at least partially. BZD, especially alprazolam (AL), possess a clear inhibitory influence on the activity of the HPA axis in both animals and humans. This effect seems to be mediated at the hypothalamic and/or suprahypothalamic level via suppression of CRH. The strong negative influence of AL on hypothalamic-pituitary-adrenal (HPA) axis agrees with its peculiar efficacy in the treatment of panic disorders and depression. BZD have also been shown to increase GH secretion via mechanisms mediated at the hypothalamic or supra-hypothalamic level, though a pituitary action cannot be ruled out. Besides the impact on HPA and somatotrope function, BDZ also significantly affect the secretion of other pituitary hormones, such as gonadotropins and. PRL, probably acting through GABAergic mediation in the hypothalamus and/or in the pituitary gland. In all, BDZ are likely to represent a useful tool to investigate GABAergic activity and clarify its role in the neuroendocrine control of anterior pituitary function; their usefulness probably overrides what had been supposed before.

  DOI：

  10.1007/bf03345110
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 甲醇 、 sodium 作用下， 生成 optically inactive 2,3-dineopentyl-succinic acid diethyl ester
  参考文献：
  名称：

  Benzodiazepines and anterior pituitary function

  摘要：

  Benzodiazepines (BDZ) are one of the most prescribed classes of drugs because of their marked anxiolytic, anticonvulsant, muscle relaxant and hypnotic effects. The pharmacological actions of BDZ depend on the activation of 2 specific receptors. The central BDZ receptor, present in several areas of the central nervous system (CNS), is a component of the GABA-A receptor, the activation of which increases GABAergic neurotransmission and is followed by remarkable neuroendocrine effects. The peripheral benzodiazepine receptors (PBR), structurally and functionally different from the GABA-A receptor, have been shown in peripheral tissues but also in the CNS, in both neurones and glial cells, and in the pituitary gland. BDZ receptors bind to a family of natural peptides called endozepines, firstly isolated from neurons and glial cells in the brain and then in several peripheral tissues as well. Endozelpines modulate several central and peripheral biological activities, including some neuroendocrine functions and synthetic BDZ are likely to mimic them, at least partially. BZD, especially alprazolam (AL), possess a clear inhibitory influence on the activity of the HPA axis in both animals and humans. This effect seems to be mediated at the hypothalamic and/or suprahypothalamic level via suppression of CRH. The strong negative influence of AL on hypothalamic-pituitary-adrenal (HPA) axis agrees with its peculiar efficacy in the treatment of panic disorders and depression. BZD have also been shown to increase GH secretion via mechanisms mediated at the hypothalamic or supra-hypothalamic level, though a pituitary action cannot be ruled out. Besides the impact on HPA and somatotrope function, BDZ also significantly affect the secretion of other pituitary hormones, such as gonadotropins and. PRL, probably acting through GABAergic mediation in the hypothalamus and/or in the pituitary gland. In all, BDZ are likely to represent a useful tool to investigate GABAergic activity and clarify its role in the neuroendocrine control of anterior pituitary function; their usefulness probably overrides what had been supposed before.

  DOI：

  10.1007/bf03345110

文献信息

• Differential gas–liquid chromatographic behaviour in diastereoisomeric systems. Part I. Symmetrically substituted dichiral hydrocarbons and ester precursors
  作者：Binyamin Feibush、Leonard Spialter

  DOI：10.1039/j29710000106

  日期：——

  Dichiral molecules are defined as those with two asymmetric centres. In the present work, the differential g.l.c. behaviour of diastereomers of 2,3-dipentylbutanes and 2,4-dipentylpentanes, wherein the pentyl groups were selected from various isomeric C5H11 moieties and cyclopentyl, have been examined. Also obtained were comparable results for synthetic precursors to these compounds, the respective

  二手性分子被定义为具有两个不对称中心的分子。在目前的工作中，2,3-二戊基丁烷和2,4-二戊基戊烷的非对映异构体的glc行为不同，其中戊基选自各种异构体C 5 H 11部分和环戊基已被检查。还获得了这些化合物的合成前体，相应的αα'-二戊基琥珀酸二乙酯和αα'-二戊基戊二酸酯，2,3-二戊基丁烷-1,4-二醇和2,4-二戊基戊烷-1,5-二乙酸酯的可比结果。二醇，以及副产物3,4-二戊基四氢呋喃和3,5-二戊基四氢吡喃。实验数据提供了有关非对映异构体构型，取代基体积的影响，手性中心之间距离的影响以及极性偶极-偶极相互作用与空间效应的关系的信息。
• Propylene polymers
  申请人：Morini Giampiero

  公开号：US20050032633A1

  公开（公告）日：2005-02-10

  The present invention relates to a solid catalyst component for the polymerization of olefins CH 2 ═CHR in which R is hydrogen or a hydrocarbon radical with 1-12 carbon atoms, comprising Mg, Ti, halogen and an electron donor selected from substituted succinates of a particular formula. Said catalyst components when used in the polymerization of olefins, and in particular of propylene, are capable to give polymers in high yields and with high isotactic index expressed in terms of high xylene insolubility.

  本发明涉及一种用于聚合烯烃CH2═CHR（其中R为氢或具有1-12个碳原子的碳氢基团）的固体催化剂组分，包括镁、钛、卤素和从特定公式的取代琥珀酸酯中选择的电子给体。当在聚合烯烃，特别是丙烯的聚合中使用该催化剂组分时，能够以高收率和以高二甲苯不溶性表示的高同构指数给出聚合物。
• SOLID TITANIUM CATALYST COMPONENT, OLEFIN POLYMERIZATION CATALYST, AND OLEFIN POLYMERIZATION METHOD
  申请人：Mitsui Chemicals, Inc.

  公开号：EP2206731A1

  公开（公告）日：2010-07-14

  The present invention provides an olefin polymerization catalyst, which is free of polyfunctional aromatic compounds and has a large particle diameter, and a solid titanium component (I) which forms the catalyst. The olefin polymerization catalyst comprises a solid titanium component (I), an organometallic compound (II) and optionally an electron donor (III) wherein the solid titanium component (I) comprising titanium, magnesium and halogen is obtainable by allowing a magnesium compound (A) having no reducing ability in a liquid state to contact with an ester compound (B) represented by the following formula (1) and a liquid titanium compound (C) in a specific order, wherein R2 and R3 are COOR1 or R, and at least one of R2 and R3 is COOR1, two or more R1 each are a monovalent hydrocarbon group having 1 to 20 carbon atoms, and two or more R are a hydrogen atom, or a hydrocarbon group having 1 to 20 carbon atoms, and at least two of Rs may be bonded each other to form a ring, and the skeleton of the ring formed may include a double bond or a hetero atom.

  本发明提供了一种烯烃聚合催化剂，该催化剂不含多官能团芳香族化合物且具有较大的颗粒直径，还提供了构成该催化剂的固体钛组分（I）。烯烃聚合催化剂由固体钛组分（I）、有机金属化合物（II）和可选的电子供体（III）组成，其中由钛、镁和卤素组成的固体钛组分（I）可通过使液态无还原能力的镁化合物（A）与下式（1）表示的酯化合物（B）和液态钛化合物（C）按特定顺序接触而获得、 其中 R2 和 R3 为 COOR1 或 R，且 R2 和 R3 中至少有一个为 COOR1，两个或两个以上的 R1 各为具有 1 至 20 个碳原子的单价烃基，两个或两个以上的 R 为氢原子，或具有 1 至 20 个碳原子的烃基，且至少两个 R 可相互键合形成环，所形成的环的骨架可包括双键或杂原子。
• SOLID TITANIUM CATALYST COMPONENT FOR ETHYLENE POLYMERIZATION, ETHYLENE POLYMERIZATION CATALYST AND ETHYLENE POLYMERIZATION METHOD
  申请人：Mitsui Chemicals, Inc.

  公开号：EP2264075A1

  公开（公告）日：2010-12-22

  Provided are a solid titanium catalyst component for ethylene polymerization which can polymerize ethylene at a high activity and which can provide an ethylene polymer having an excellent particle property, an ethylene polymerization catalyst and an ethylene polymerization method in which the catalyst is used. The solid titanium catalyst component (I) for ethylene polymerization according to the present invention is obtained by bringing a liquid magnesium compound (A) including a magnesium compound, an electron donor (a) having 1 to 5 carbon atoms and an electron donor (b) having 6 to 30 carbon atoms into contact with a liquid titanium compound (C) under the presence of an electron donor (B) and includes titanium, magnesium and a halogen. The ethylene polymerization catalyst of the present invention includes the component (I) and an organic metal compound catalyst component (II). Further, the ethylene polymerization method of the present invention is a method for polymerizing ethylene under the presence of the catalyst.

  本发明提供了一种乙烯聚合用固体钛催化剂组分、乙烯聚合催化剂和使用该催化剂的乙烯聚合方法，该乙烯聚合用固体钛催化剂组分能以高活性聚合乙烯，并能提供具有优异颗粒性能的乙烯聚合物。 根据本发明的乙烯聚合用固体钛催化剂组分（I）是在电子供体（B）存在的情况下，将包括镁化合物、具有 1 至 5 个碳原子的电子供体（a）和具有 6 至 30 个碳原子的电子供体（b）的液态镁化合物（A）与液态钛化合物（C）接触而得到的，液态钛化合物（C）包括钛、镁和卤素。本发明的乙烯聚合催化剂包括组分（I）和有机金属化合物催化剂组分（II）。此外，本发明的乙烯聚合方法是一种在催化剂存在下聚合乙烯的方法。
• Process for the preparation of heterophasic propylene polymer compositions
  申请人：Basell Poliolefine Italia S.r.l.

  公开号：EP2594593A1

  公开（公告）日：2013-05-22

  A process for the preparation of propylene polymer compositions comprising from 50 to 90 % by weight of a propylene (co)polymer fraction insoluble in xylene at 25°C, and from 10 to 50% by weight of an ethylene copolymer fraction soluble in xylene at 25°C, said process comprising: (i) a first step of polymerizing propylene in the optional presence of ethylene and/or C4-C10 alpha olefins, to produce a propylene (co)polymer being for at least 85% by weight insoluble in xylene at 25°C; and (ii) a successive step, carried out in gas-phase, in the presence of the product coming from step (i), of copolymerizing a mixture of ethylene with one or more α-olefins CH2=CHR in which R is a hydrocarbon radical having 1-10 carbon atoms, to produce an ethylene copolymer; the process being carried out in the presence of a catalyst system comprising: the product obtained by contacting: (a) a solid catalyst component comprising a magnesium halide, a titanium compound having at least a Ti-halogen bond and at least two internal electron donor compounds one of which being present in an amount from 35 to 90% by mol with respect to the total amount of donors and being selected from succinates and the other being selected from 1,3-diethers, the total amount of internal electron donor compounds being lower than 14.0% by weight with respect to the total weight of the solid catalyst component; with (b) an aluminum hydrocarbyl compound, and optionally with (c) an external electron donor compound.

  一种制备丙烯聚合物组合物的工艺，该组合物包括在 25℃下不溶于二甲苯的丙烯（共）聚合物部分（按重量计）50%至 90%，以及在 25℃下可溶于二甲苯的乙烯共聚物部分（按重量计）10%至 50%，所述工艺包括： (i) 第一步，在乙烯和/或 C4-C10 α 烯烃任选存在的情况下，使丙烯聚合，生成至少 85% （按重量计）在 25°C 时不溶于二甲苯的丙烯（共）聚合物；以及 (ii) 在气相中，在步骤(i)的产物存在下，进行乙烯与一种或多种 α-烯烃 CH2=CHR 的混合物共聚的连续步骤，其中 R 是具有 1-10 个碳原子的烃基，以生产乙烯共聚物； 该工艺在催化剂体系存在下进行，该催化剂体系包括： 与下列物质接触得到的产物 (a) 固体催化剂组分，包括卤化镁、至少具有一个钛-卤素键的钛化合物和至少两个内 部电子供体化合物，其中一个电子供体化合物的含量为供体总量的 35-90%（摩尔）， 且选自琥珀酸酯，另一个选自 1，3-二醚，内部电子供体化合物的总量低于固体催 化剂组分总重量的 14.0%（重量比）；与 (b) 烃基铝化合物，以及可选的 (c) 外部电子供体化合物。