4-酰基-18-冠醚 | 68865-32-7

• 物质功能分类: 化学试剂 - 有机试剂 - 冠醚
• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 4-酰基-18-冠醚
• 中文别名: 4-丙烯酰胺苯并-18-冠醚；4-酰基-18-冠醚-6
• 英文名称: 4-acryloylaminobenzo-18-crown-6
• 英文别名: 4-Acryloylamidobenzo-18-crown-6；N-(2,5,8,11,14,17-hexaoxabicyclo[16.4.0]docosa-1(18),19,21-trien-20-yl)prop-2-enamide
• CAS: 68865-32-7
• 化学式: C₁₉H₂₇NO₇
• 分子量: 381.426
• InChiKey: UGHKKCVGQTWASH-UHFFFAOYSA-N

物化性质

• 熔点：
  108 °C
• 沸点：
  508.82°C (rough estimate)
• 密度：
  1.2977 (rough estimate)
• 稳定性/保质期：

  遵照规定使用和储存，则不会分解。

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  27
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  84.5
• 氢给体数：
  1
• 氢受体数：
  7

安全信息

• 安全说明：
  S24/25
• 储存条件：
  存储于0至6℃的阴凉干燥处。

反应信息

• 作为反应物：
  描述：

  1,4,8,11-四氮杂环十四烷 、 4-酰基-18-冠醚 在 2,4-二叔丁基苯酚 、 对甲苯磺酸 作用下， 以 氯仿 为溶剂， 反应 48.0h， 以69%的产率得到N-(2,3,5,6,8,9,11,12,14,15-Decahydro-1,4,7,10,13,16-benzohexaoxacyclooctadecin-18-yl)-3-(1,4,8,11-tetraazacyclotetradecan-1-yl)propionamide
  参考文献：
  名称：

  Fensterbank, Helene; Zhu, Jiarong; Riou, Didier, Journal of the Chemical Society. Perkin transactions I, 1999, # 7, p. 811 - 815

  摘要：

  DOI：

文献信息

• Compositions and associated methods for radioisotope-binding microparticles
  申请人：Biosphere Medical, Inc.

  公开号：US10434200B2

  公开（公告）日：2019-10-08

  The present disclosure relates to polymeric materials that may be labeled with a radioisotope, to processes for producing the labeled polymeric material, and to methods of using the materials in analytical and therapeutic applications. Specifically, the disclosure relates to injectable and implantable microparticles, such as microspheres, which are associated with radioisotopes such that the microparticles are both therapeutic and detectable. The radioisotope-containing microparticles are useful for embolization and other therapeutic medical applications.

  本公开涉及可以用放射性同位素标记的聚合材料、标记聚合材料的生产工艺以及在分析和治疗应用中使用这些材料的方法。具体而言，本公开涉及可注射和植入的微颗粒，如微球，这些微颗粒与放射性同位素相关联，从而使微颗粒既可治疗又可检测。含放射性同位素的微颗粒可用于栓塞和其他治疗性医疗应用。
• US20140271461A1
  申请人：——

  公开号：US20140271461A1

  公开（公告）日：2014-09-18
• COMPOSITIONS AND ASSOCIATED METHODS FOR RADIOISOTOPE-BINDING MICROPARTICLES
  申请人：Biosphere Medical, Inc.

  公开号：US20170333579A1

  公开（公告）日：2017-11-23

  The present disclosure relates to polymeric materials that may be labeled with a radioisotope, to processes for producing the labeled polymeric material, and to methods of using the materials in analytical and therapeutic applications. Specifically, the disclosure relates to injectable and implantable microparticles, such as microspheres, which are associated with radioisotopes such that the microparticles are both therapeutic and detectable. The radioisotope-containing microparticles are useful for embolization and other therapeutic medical applications.
• US9687573B2
  申请人：——

  公开号：US9687573B2

  公开（公告）日：2017-06-27
• [EN] COMPOSITIONS AND ASSOCIATED METHODS FOR RADIOISOTOPE-BINDING MICROPARTICLES<br/>[FR] COMPOSITIONS ET PROCÉDÉS ASSOCIÉS POUR DES MICROPARTICULES DE LIAISON DE RADIO-ISOTOPE
  申请人：BIOSPHERE MEDICAL INC

  公开号：WO2014159759A1

  公开（公告）日：2014-10-02

  The present disclosure relates to polymeric materials that may be labeled with a radioisotope, to processes for producing the labeled polymeric material, and to methods of using the materials in analytical and therapeutic applications. Specifically, the disclosure relates to injectable and implantable microparticles, such as microspheres, which are associated with radioisotopes such that the microparticles are both therapeutic and detectable. The radioisotope-containing microparticles are useful for embolization and other therapeutic medical applications.