4-oxo-3-(1-piperidyl)methyl-4-(pyridin-3-yl)butyric acid | 220301-12-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 酮酸及其衍生物
• 英文名称: 4-oxo-3-(1-piperidyl)methyl-4-(pyridin-3-yl)butyric acid
• 英文别名: 4-oxo-3-(piperidylmethyl)-4-(pyridin-3-yl)butanoic acid；4-oxo-4-(3-pyridyl)-3-(1-piperidyl)methylbutyric acid；4-oxo-3-(piperidylmethyl)-4-(3-pyridyl)butanoic acid；4-Oxo-3-(piperidin-1-ylmethyl)-4-pyridin-3-ylbutanoic acid
• CAS: 220301-12-2
• 化学式: C₁₅H₂₀N₂O₃
• 分子量: 276.335
• InChiKey: MABSYCMJYLTRMJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.4
• 重原子数：
  20
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  70.5
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  哌啶 、 聚合甲醛 生成 4-oxo-3-(1-piperidyl)methyl-4-(pyridin-3-yl)butyric acid
  参考文献：
  名称：

  Compound having effect of promoting neuron differentiation

  摘要：

  一种新型的青霉胺衍生物，具有极好的促进神经元分化的效果，并可作为治疗中枢神经系统紊乱、治疗周围神经系统紊乱等的药物。

  公开号：

  US06384063B1

文献信息

• NOVEL COMPOUND HAVING EFFECT OF PROMOTING NEURON DIFFERENTIATION
  申请人：Nippon Kayaku Kabushiki Kaisha

  公开号：EP0999204A1

  公开（公告）日：2000-05-10

  A novel cystacycline derivative provided according to the present invention has a novel neuron differentiation promoting activity and is thus useful as a medicament for the treatment of central and peripheral nervous system disorders and the like.

  根据本发明提供的一种新型胱氨酸衍生物具有促进神经元分化的新型活性，因此可用作治疗中枢和周围神经系统疾病等的药物。
• COMPOUND HAVING EFFECT OF PROMOTING NEURON DIFFERENTIATION
  申请人：NIPPON KAYAKU CO., LTD.

  公开号：EP1240144A2

  公开（公告）日：2002-09-18
• US6384063B1
  申请人：——

  公开号：US6384063B1

  公开（公告）日：2002-05-07
• US6399606B1
  申请人：——

  公开号：US6399606B1

  公开（公告）日：2002-06-04
• [EN] NEUROPROTECTIVE AGENTS AND METHODS RELATED THERETO<br/>[FR] AGENTS NEUROPROTECTEURS ET METHODES ASSOCIEES
  申请人：NIPPON KAYAKU KK

  公开号：WO2001040187A2

  公开（公告）日：2001-06-07

  Neuroprotective agents are disclosed having structure: (I) and stereoisomers and pharmaceutically acceptable salts thereof, wherein R1 is alkyl, substituted alkyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, heterocycle, substituted heterocycle, heterocyclealkyl or substituted heterocyclealkyl; R2 is -OR2a or -NR2bR2c; R3 is hydrogen, keto, -C(=O)OR3a or -C(=O)NR3bR3c; R4 is hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, -C(=O)R4a, -C(=O)OR4b, -C(=O)NR4cR4d, -OC(=O)NR4cR4d or -SO2R4c or wherein R3 and R4 taken together form a heterocyclic ring or substituted heterocyclic ring; and R5 is hydrogen, alkyl or substituted alkyl. Such compounds have utility in the treatment of conditions which benefit from administration of neuroprotective agents generally, including treatment of central and peripheral nervous condition as well as promoting nerve cell differentiation. Methods of treating such conditions are also disclosed, as are pharmaceutical compositions containing one or more of the compounds of this invention.