3,6-Dibenzyl-9-[6-(oxiran-2-yl)-6-oxohexyl]-1,4,7,10-tetrazabicyclo[10.3.0]pentadecane-2,5,8,11-tetrone

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 3,6-Dibenzyl-9-[6-(oxiran-2-yl)-6-oxohexyl]-1,4,7,10-tetrazabicyclo[10.3.0]pentadecane-2,5,8,11-tetrone
• 化学式: C₃₃H₄₀N₄O₆
• 分子量: 588.7
• InChiKey: LLOKIGWPNVSDGJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  43
• 可旋转键数：
  11
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  137
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• Generating hepatocytes
  申请人：The J. David Gladstone Institutes, a testamentary trust established under the Will of J. David Gladstone

  公开号：US10227565B2

  公开（公告）日：2019-03-12

  Compositions and methods are described herein for inducing reprogramming of non-pluripotent cells across lineage and differentiation boundaries to generate endodermal progenitor cells and hepatocytes. Compositions and methods for expansion of endodermal progenitor cells without loss of phenotype are also described herein.

  本文描述了诱导非多能细胞跨系和分化边界重编程以产生内胚层祖细胞和肝细胞的组合物和方法。本文还描述了在不丧失表型的情况下扩增内胚层祖细胞的组合物和方法。
• Methods and compositions for producing pancreatic beta cells
  申请人：The Regents of the University of California

  公开号：US11332716B2

  公开（公告）日：2022-05-17

  Compositions and methods of producing mammalian cell populations that include a high proportion of pancreatic beta cells are described herein. Such cell populations are useful for treatment of diabetes. Also provided are materials and methods for the direct differentiation of stem cells, such as embryonic stem cells, into functional pancreatic beta cells. The disclosure provides the benefit of direct differentiation, which results in the production of functional pancreatic beta cells efficiently and at low cost.

  本文描述了生产包括高比例胰腺β细胞的哺乳动物细胞群的组合物和方法。这种细胞群可用于治疗糖尿病。还提供了将胚胎干细胞等干细胞直接分化为功能性胰腺β细胞的材料和方法。本公开内容提供了直接分化的好处，可高效低成本地生产功能性胰腺β细胞。
• GENERATING DEFINITIVE ENDODERM AND PANCREATIC PROGENITOR CELLS
  申请人：The J. David Gladstone Institutes, A Testamentary Trust Established under The Will of J. David Gladstone

  公开号：EP3024926B1

  公开（公告）日：2021-03-03
• SMALL MOLECULE CELLULAR REPROGRAMMING TO GENERATE NEURONAL CELLS
  申请人：The J. David Gladstone Institutes, A Testamentary Trust Established under The Will of J. David Gladstone

  公开号：EP3039126B1

  公开（公告）日：2019-10-09
• GENERATING HEPATOCYTES
  申请人：Zhu Saiyong

  公开号：US20150175962A1

  公开（公告）日：2015-06-25

  Compositions and methods are described herein for inducing reprogramming of non-pluripotent cells across lineage and differentiation boundaries to generate endodermal progenitor cells and hepatocytes. Compositions and methods for expansion of endodermal progenitor cells without loss of phenotype are also described herein.