5-methyl-2-(propylthio)pyridine | 5613-18-3

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: 5-methyl-2-(propylthio)pyridine
• 英文别名: 6-Propylmercapto-3-picolin；5-methyl-2-propylsulfanyl-pyridine；5-Methyl-2-propylsulfanylpyridine
• CAS: 5613-18-3
• 化学式: C₉H₁₃NS
• 分子量: 167.275
• InChiKey: FGIPLJMVOOCWIE-UHFFFAOYSA-N

物化性质

• 沸点：
  263.0±20.0 °C(Predicted)
• 密度：
  1.03±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  38.2
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-溴-5-甲基吡啶 、 diisopropylammonium bis(catecholato)(3-mercaptopropyl)silicate 在 tris(2,2-bipyridine)ruthenium(II) hexafluorophosphate 、 氯化镍二甲氧基乙烷 、 4,4'-二叔丁基-2,2'-二吡啶 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 30.0h， 以81%的产率得到5-methyl-2-(propylthio)pyridine
  参考文献：
  名称：

  通过光还原/镍双重催化进行硫醚化

  摘要：

  高价烷基硅酸盐代表了在光氧化还原条件下产生烷基自由基的新的和易于获得的前体。由这种硅酸盐产生的烷基自由基可作为有效的氢原子从硫醇中提取出氢原子，从而提供了噻吩基。可以将以这种方式产生的反应性硫物质漏入镍介导的交叉偶联循环中，该循环使用芳族溴化物提供硫醚。描述了该反应的偶然发现及其用于将各种芳族硫醇与各种芳基和杂芳基溴化物进行硫醚化的过程。S–H选择性H原子抽象事件使宽泛的官能团（包括带有质子部分的官能团）能够被耐受。

  DOI：

  10.1021/acs.orglett.6b00208

文献信息

• 2-imino-1,3-thiazine derivatives
  申请人：Hanasaki Koji

  公开号：US20070088020A1

  公开（公告）日：2007-04-19

  The present invention relates to 2-imino-1,3-thiazine derivatives, in specific, 2-imino-1,3-thiazine derivatives having a selective antagonistic activity or agonistic activity to a cannabinoid type 2 receptor and their pharmaceutical use.

  本发明涉及2-亚氨基-1,3-噻嗪衍生物，具体地说，涉及具有选择性拮抗或激动大麻素类型2受体活性的2-亚氨基-1,3-噻嗪衍生物及其药物用途。
• Antipruritics
  申请人：Yasui Kiyoshi

  公开号：US20080312292A1

  公开（公告）日：2008-12-18

  It is intended to provide antipruritics (drugs to control itching, antiitch agents and drugs to stop itching). It is found out that a compound having an agonistic activity to the cannabinoid receptor shows an antipruritics effect.

  这句话的意思是：它旨在提供止痒药（控制瘙痒的药物、抗瘙痒剂和止痒药物）。发现一种具有类脂激素受体激动活性的化合物具有止痒效果。
• Novel use of cannabinoid receptor agonist
  申请人：Arimura Akinori

  公开号：US20070027144A1

  公开（公告）日：2007-02-01

  An inhibitor for an inflammatory cell infiltration in the respiratory tract, an inhibitor for hyperirritability in the respiratory tract, a muciparous inhibitor, or a bronchodilator which contains as an active ingredient a compound represented by the formula (I) or (II): wherein R 1 is the group represented by the formula: —C(=Z)-W—R 4 wherein Z is an oxygen atom or the like; W is an oxygen atom or the like; R 4 is optionally substituted alkyl or the like; R 2 and R 3 are independently optionally substituted alkyl or the like; or R 2 and R 3 are taken together to form optionally substituted alkylene which may contain a heteroatom(s); m is an integer of 0 to 2; A is optionally substituted aryl or optionally substituted heteroaryl; wherein R 5 is the group represented by the formula: —Y 1 —Y 2 —Y 3 —R a wherein Y 1 and Y 3 are each independently a bond or the like; Y 2 is —C(═O)—NR b — or the like; R a is optionally substituted alkyl, or the like; R b is a hydrogen atom or the like; R 6 is a hydrogen atom or the like; R 7 and R 8 are each independently optionally substituted alkyl or the like; or R 7 and R 8 are taken together with the adjacent carbon atoms to form a 5 to 8 membered ring which may contain a heteroatom(s) and/or an unsaturated bond(s); R 9 is optionally substituted alkyl which may contain a heteroatom(s) and/or an unsaturated bond(s), or the like; X is a oxygen atom or the like.
• US7183275B2
  申请人：——

  公开号：US7183275B2

  公开（公告）日：2007-02-27
• US7420053B2
  申请人：——

  公开号：US7420053B2

  公开（公告）日：2008-09-02