6-Methyl-4-(methylamino)-5-oxoheptanoic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 6-Methyl-4-(methylamino)-5-oxoheptanoic acid
• 英文别名: 6-methyl-4-(methylamino)-5-oxoheptanoic acid
• 化学式: C₉H₁₇NO₃
• 分子量: 187.24
• InChiKey: CLZYHHJDMWJIKU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.8
• 重原子数：
  13
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  66.4
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• PEPTIDES USEFUL IN THE TREATMENT AND/OR CARE OF SKIN, MUCOUS MEMBRANES, SCALP AND/OR HAIR AND THEIR USE IN COSMETIC OR PHARMACEUTICAL COMPOSITIONS
  申请人：Lipotec, S.A.

  公开号：EP2331560B1

  公开（公告）日：2019-05-08
• NOVEL RADIOMETAL-BINDING COMPOUNDS FOR DIAGNOSIS OR TREATMENT OF PROSTATE SPECIFIC MEMBRANE ANTIGEN-EXPRESSING CANCER
  申请人：PROVINCIAL HEALTH SERVICES AUTHORITY

  公开号：US20200339625A1

  公开（公告）日：2020-10-29

  This application relates to compounds of Formula (I-a) or Formula (I-b), or is salts or solvates thereof. R 1 is —(CH 2 ) 5 CH 3 or comprises 2-4 fused benzene rings. R 2 is I, Br, F, Cl, H, OH, OCH 3 , NH 2 , NO 2 or CH 3 . R 3 is a peptide-bonded glycine, aspartate or glutamate or is glutamate peptide bonded through C delta . L is —CH 2 NH—, —(CH 2 ) 2 NH—, —(CH 2 ) 3 NH—, or —(CH 2 ) 4 NH—. R 4 is a radiometal chelator optionally bound by a radiometal. Variable ‘n’ is 1-3. The compounds may be useful for imaging prostate specific membrane antigen (PSMA)-expressing tissues or for treating PSMA-expressing diseases (e.g. cancer).
• US9656972B2
  申请人：——

  公开号：US9656972B2

  公开（公告）日：2017-05-23