5-(diaminomethylideneazaniumyl)-2-[[2-[[2-(phenylmethoxycarbonylamino)acetyl]amino]acetyl]amino]pentanoate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 5-(diaminomethylideneazaniumyl)-2-[[2-[[2-(phenylmethoxycarbonylamino)acetyl]amino]acetyl]amino]pentanoate
• 化学式: C18H26N6O6
• 分子量: 422.4
• InChiKey: KKOWZNDQAYTLHV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.1
• 重原子数：
  30
• 可旋转键数：
  13
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  198
• 氢给体数：
  6
• 氢受体数：
  7

文献信息

• Compositions and methods for thrombin generation assay
  申请人：The Scripps Research Institute

  公开号：US11136370B2

  公开（公告）日：2021-10-05

  In various embodiments, disclosed herein are assays for measuring thrombin generated (TG) in a blood sample, comprising: incubating the blood sample with TF, FIXa, and CaCl2; and measuring TG in the blood sample. Also disclosed herein are assays for determining a bleeding risk in a subject, comprising obtaining a blood sample from the subject; adding to the blood sample TF and/or FIXa; determining the amount of coagulation factor VIII (FVIII:C) in the blood sample; and determining (a) a mild bleeding risk in the subject if the amount of FVIII:C in the sample is >5 IU/dL, (b) a moderate bleeding risk in the subject if the amount of FVIII:C in the sample is 1-5 IU/dL, and (c) a severe bleeding risk in the subject if the amount of FVIII:C in the subject is <1 IU/dL.

  在各种实施方案中，本文公开了用于测量血液样本中凝血酶生成量（TG）的检测方法，包括：用 TF、FIXa 和 CaCl2 培养血液样本；以及测量血液样本中的 TG。本文还公开了用于确定受试者出血风险的检测方法，包括：获取受试者的血样；向血样中添加 TF 和/或 FIXa；确定血样中凝血因子 VIII (FVIII. C) 的含量；以及测定血样中凝血酶原 (TG) 的含量：C）；如果样本中 FVIII:C 的量大于 5 IU/dL，则确定（a）受试者有轻度出血风险；如果样本中 FVIII:C 的量为 1-5 IU/dL，则确定（b）受试者有中度出血风险；如果受试者中 FVIII:C 的量小于 1 IU/dL，则确定（c）受试者有严重出血风险。
• COMPOSITIONS AND METHODS FOR ANTI-THROMBOTIC AND HEMOSTATIC THERAPIES
  申请人：The Scripps Research Institute

  公开号：EP3455636A1

  公开（公告）日：2019-03-20
• [EN] COMPOSITIONS AND METHODS FOR ANTI-THROMBOTIC AND HEMOSTATIC THERAPIES<br/>[FR] COMPOSITIONS ET MÉTHODES POUR THÉRAPIES ANTI-THROMBOTIQUES ET HÉMOSTATIQUES
  申请人：SCRIPPS RESEARCH INST

  公开号：WO2017197332A1

  公开（公告）日：2017-11-16

  In various embodiments, disclosed herein are assays for measuring thrombin generated (TG) in a blood sample, comprising: incubating the blood sample with TF, FIXa, and CaCl2; and measuring TG in the blood sample. Also disclosed herein are assays for determining a bleeding risk in a subject, comprising obtaining a blood sample from the subject; adding to the blood sample TF and/or FIXa; determining the amount of coagulation factor VIII (FVIII:C) in the blood sample; and determining (a) a mild bleeding risk in the subject if the amount of FVIII:C in the sample is >5 IU/dL, (b) a moderate bleeding risk in the subject if the amount of FVIII:C in the sample is 1-5 IU/dL, and (c) a severe bleeding risk in the subject if the amount of FVIII:C in the subject is <1 IU/dL.