Methyl 2-(undec-10-enylamino)acetate | 1209413-29-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Methyl 2-(undec-10-enylamino)acetate
• CAS: 1209413-29-5
• 化学式: C₁₄H₂₇NO₂
• 分子量: 241.374
• InChiKey: AFKBWSAXJOJCQB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  17
• 可旋转键数：
  13
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.79
• 拓扑面积：
  38.3
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  Methyl 2-(undec-10-enylamino)acetate 、 9-芴甲基-N-琥珀酰亚胺基碳酸酯 在 水 、 sodium hydroxide 、 碳酸氢钠 作用下， 以 1,4-二氧六环 、 水 为溶剂， 生成 N-[(9H-fluoren-9-ylmethoxy)carbonyl]-N-10-undecen-1-yl-glycine
  参考文献：
  名称：

  Application of ring-closing metathesis macrocyclization to the development of Tsg101-binding antagonists

  摘要：

  HIV-1 viral budding involves binding of the viral Gag(p6) protein to the ubiquitin E2 variant domain of the human tumor susceptibility gene 101 protein (Tsg101). Recognition of p6 by Tsg101 is mediated in part by a proline-rich motif that contains the sequence 'Pro-Thr-Ala-Pro' ('PTAP'). Using the p6-derived 9-mer sequence 'PEPTAPPEE', we had previously improved peptide binding affinity by employing N-alkylglycine ('peptoid') residues. The current study applies ring-closing metathesis macrocyclization strategies to Tsg101-binding peptide-peptoid hybrids as an approach to stabilize binding conformations and to observe the effects of such macrocyclization on Tsg101-binding affinity and bioavailability. Published by Elsevier Ltd.

  DOI：

  10.1016/j.bmcl.2009.10.105
• 作为产物：
  描述：

  11-溴-1-十一烯 、 甘氨酸甲酯盐酸盐 在 三乙胺 作用下， 以 乙腈 为溶剂， 生成 Methyl 2-(undec-10-enylamino)acetate
  参考文献：
  名称：

  Application of ring-closing metathesis macrocyclization to the development of Tsg101-binding antagonists

  摘要：

  HIV-1 viral budding involves binding of the viral Gag(p6) protein to the ubiquitin E2 variant domain of the human tumor susceptibility gene 101 protein (Tsg101). Recognition of p6 by Tsg101 is mediated in part by a proline-rich motif that contains the sequence 'Pro-Thr-Ala-Pro' ('PTAP'). Using the p6-derived 9-mer sequence 'PEPTAPPEE', we had previously improved peptide binding affinity by employing N-alkylglycine ('peptoid') residues. The current study applies ring-closing metathesis macrocyclization strategies to Tsg101-binding peptide-peptoid hybrids as an approach to stabilize binding conformations and to observe the effects of such macrocyclization on Tsg101-binding affinity and bioavailability. Published by Elsevier Ltd.

  DOI：

  10.1016/j.bmcl.2009.10.105

文献信息

• Novel Silane Compounds and Use of Same for Functionalizing Solid Supports and Immobilizing Biological Molecules on These Supports
  申请人：Martin Franck

  公开号：US20090029875A1

  公开（公告）日：2009-01-29

  The invention relates to novel silane compounds corresponding to the formula (I) below: A-E-X  (I) in which: X represents a silyl group capable of creating a covalent bond after reaction with the hydroxyl or hydride functional groups of a support; E represents an organic spacer group; A represents a group chosen from the groups of formulae below: in which: Z 1 to Z 5 independently represent a hydrogen atom or a halogen atom; Z 6 and Z 7 represent a group for protecting the phosphonic acid functional group, a hydrogen atom or a monovalent cation; Z 8 to Z 12 independently represent a group for protecting the carboxylic acid functional group, a hydrogen atom or a monovalent cation; and Z 13 represents an imidazole, N-hydroxysuccinimide, nitrophenyl, pentafluorophenyl or acid anhydride group. Use of these silane compounds for functionalizing solid supports and for immobilizing biological molecules on these supports.
• US9657042B2
  申请人：——

  公开号：US9657042B2

  公开（公告）日：2017-05-23
• Application of ring-closing metathesis macrocyclization to the development of Tsg101-binding antagonists
  作者：Fa Liu、Andrew G. Stephen、Abdul A. Waheed、Eric O. Freed、Robert J. Fisher、Terrence R. Burke

  DOI：10.1016/j.bmcl.2009.10.105

  日期：2010.1

  HIV-1 viral budding involves binding of the viral Gag(p6) protein to the ubiquitin E2 variant domain of the human tumor susceptibility gene 101 protein (Tsg101). Recognition of p6 by Tsg101 is mediated in part by a proline-rich motif that contains the sequence 'Pro-Thr-Ala-Pro' ('PTAP'). Using the p6-derived 9-mer sequence 'PEPTAPPEE', we had previously improved peptide binding affinity by employing N-alkylglycine ('peptoid') residues. The current study applies ring-closing metathesis macrocyclization strategies to Tsg101-binding peptide-peptoid hybrids as an approach to stabilize binding conformations and to observe the effects of such macrocyclization on Tsg101-binding affinity and bioavailability. Published by Elsevier Ltd.