Cinatrin C

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Cinatrin C
• 英文别名: 4-dodecyl-3,4-dihydroxy-5-oxooxolane-2,3-dicarboxylic acid
• 化学式: C₁₈H₃₀O₈
• 分子量: 374.4
• InChiKey: NFUSNACHMOKOQN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  26
• 可旋转键数：
  13
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  141
• 氢给体数：
  4
• 氢受体数：
  8

文献信息

• METHOD FOR OBTAINING CINATRINS C3 AND C1
  申请人：Noheda Marin Pedro

  公开号：US20110275838A1

  公开（公告）日：2011-11-10

  The present invention relates to a process for obtaining cinatrins C 1 and C 3 and derivatives thereof which comprises the hydroxylation of a compound of formula (III). The invention also relates to the intermediates of said synthesis and to their use for obtaining cinatrins C 1 and C 3 and derivatives thereof

  本发明涉及一种获得cinatrins C1和C3及其衍生物的过程，包括将式（III）化合物进行羟基化。本发明还涉及所述合成的中间体及其用于获得cinatrins C1和C3及其衍生物的用途。
• Phospholipase A2 inhibitor, microorganisms producing said inhibitor and processes for its production
  申请人：SHIONOGI SEIYAKU KABUSHIKI KAISHA trading under the name of SHIONOGI & CO. LTD.

  公开号：EP0405864A2

  公开（公告）日：1991-01-02

  A compound of the formula (I); wherein R1, R2, and R3 are -COOR4, -COOR5, and -COOR6, respectively; R4, R5, and R6, are each hydrogen, lower alkyl, or alkali metal; W is hydroxyl; X, Y, and Z are each hydrogen or hydroxyl; the dotted line indicates the presence or absence of a single bond; and wherein W/R3, X/R1, and/or Z/R3 may be combined together, to form a lactone, which compound is useful as a phospholipase A2 inhibitor. A process for the production of the compound (I), a cell culture of a microorganism Circinotrichum falcatisporum RF-641 producing the same and pharmaceutical compositions containing the same are also provided.

  式 (I) 的化合物； 其中R1、R2和R3分别为-COOR4、-COOR5和-COOR6；R4、R5和R6各自为氢、低级烷基或碱金属；W为羟基；X、Y和Z各自为氢或羟基；虚线表示存在或不存在单键；W/R3、X/R1和/或Z/R3可结合在一起，形成内酯，该化合物可用作磷脂酶A2抑制剂。本发明还提供了化合物（I）的生产工艺、产生该化合物的微生物Circinotrichum falcatisporum RF-641的细胞培养物以及含有该化合物的药物组合物。
• US5099034A
  申请人：——

  公开号：US5099034A

  公开（公告）日：1992-03-24
• US5120647A
  申请人：——

  公开号：US5120647A

  公开（公告）日：1992-06-09