2-[(2-Ammoniopropanoyl)amino]-3-(4-hydroxyphenyl)propanoate | 19659-02-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-[(2-Ammoniopropanoyl)amino]-3-(4-hydroxyphenyl)propanoate
• 英文别名: 2-(2-azaniumylpropanoylamino)-3-(4-hydroxyphenyl)propanoate
• CAS: 19659-02-0
• 化学式: C12H16N2O4
• mdl: MFCD03019172
• 分子量: 252.27
• InChiKey: ALZVPLKYDKJKQU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.5
• 重原子数：
  18
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.333
• 拓扑面积：
  113
• 氢给体数：
  4
• 氢受体数：
  5

文献信息

• SOLOMONAMIDE ANALOGUE COMPOUNDS, PHARMACEUTICALS CONTAINING SOLOMONAMIDE ANALOGUE COMPOUNDS, AND PROCESSES FOR THE PREPARATION THEREOF
  申请人：COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH

  公开号：US20150291659A1

  公开（公告）日：2015-10-15

  Solomanamide analogues of Formula-I having anti-inflammatory activity, and viable synthetic routes for the preparation of such analogues, including the synthesis of macrocyclic core of Salomanamide analogues. The Solomanamide analogues of Formula-I or their pharmaceutical salt may be provided in a pharmaceutical composition and administered in an effective amount for the treatment of inflammation and/or pain.

  公式I的Solomanamide类似物具有抗炎活性，并且具有制备这种类似物的可行合成路线，包括制备Salomanamide类似物的大环核心的合成。公式I的Solomanamide类似物或其药物盐可以在药物组合物中提供，并以有效剂量用于治疗炎症和/或疼痛。
• Nutrient compositions
  申请人：The Montefiore Hospital Association of Western Pennsylvania

  公开号：EP0182356A2

  公开（公告）日：1986-05-28

  A nutrient composition includes at least two oligopeptides of amino acids having in the N-terminal position of at least one oligopeptide a residue of glycine and having in the N-terminal position of at least one oligopeptide a residue of L-alanine, L-lysine or L-arginine. The aqueous compositions may also contain free amino acids and may contain other nutrient substances such as fats, oligosaccharides, minerals, trace elements, vitamins and free amino acids. The compositions are intended for oral or parenteral use with mammals. Compositions having dipeptide concentrations higher than prior art compositions are disclosed. Compositions containing elevated concentrations of total protein greater than heretofor proposed employ both the described oligopeptides and also free amino acids.

  一种营养组合物包括至少两种氨基酸寡肽，其中至少一种寡肽的 N 端位置有甘氨酸残基，至少一种寡肽的 N 端位置有 L-丙氨酸、L-赖氨酸或 L-精氨酸残基。水性组合物还可能含有游离氨基酸，并可能含有其他营养物质，如脂肪、低聚糖、矿物质、微量元素、维生素和游离氨基酸。组合物用于哺乳动物的口服或肠道外使用。已公开的组合物的二肽浓度高于现有技术组合物。总蛋白质浓度高于现有技术的组合物既采用了所述的低聚肽，也采用了游离氨基酸。
• DIACETAL COMPOSITION, PROCESS FOR THE PREPARATION OF THE SAME, NUCLEATING AGENT FOR POLYOLEFINS CONTAINING THE SAME, POLYOLEFIN RESIN COMPOSITIONS, AND MOLDINGS
  申请人：NEW JAPAN CHEMICAL CO.,LTD.

  公开号：EP0962459A1

  公开（公告）日：1999-12-08

  This invention provides a granular or powdery diacetal composition comprising: (a) at least one diacetal such as 1,3:2,4-O-dibenzylidene-D-sorbitol or a nucleus-substituted derivative thereof, and (b) at least one binder selected from the group consisting of neutral or weakly acidic monovalent organic acids, neutral or weakly acidic polyvalent organic acids, partial salts of neutral or weakly acidic polyvalent organic acids, salts of sulfuric acid ester, sulfonic acid salts, salts of phosphoric acid ester, phosphoric acid esters, phosphorous acid esters and aluminum salts of a neutral or weakly acidic monovalent organic acid, the binder being uniformly dispersed on the surface and in the interior of the particles of the granular or powdery diacetal composition; a process for preparing the composition; a polyolefin resin nucleating agent comprising the composition; a resin composition containing the nucleating agent and a polyolefin resin; and a polyolefin resin molded article.

  本发明提供了一种颗粒状或粉末状的二缩醛组合物，其中包括 (a) 至少一种二缩醛，如 1,3:2,4-O-二亚苄基-D-山梨醇或其核取代衍生物，和 (b) 至少一种粘合剂，该粘合剂选自以下组别：中性或弱酸性一价有机酸、中性或弱酸性多价有机酸、中性或弱酸性多价有机酸的部分盐、硫酸酯盐、磺酸盐、磷酸酯盐、磷酸酯盐、磷酸酯、磷酸酯和中性或弱酸性单价有机酸的铝盐，粘合剂均匀地分散在颗粒状或粉末状二缩醛组合物的颗粒表面和内部；制备该组合物的工艺；包含该组合物的聚烯烃树脂成核剂；包含成核剂和聚烯烃树脂的树脂组合物；以及聚烯烃树脂模塑制品。
• ANTIBACTERIAL COMPOSITIONS
  申请人：KURITA WATER INDUSTRIES LTD.

  公开号：EP1110455A1

  公开（公告）日：2001-06-27

  An antimicrobial composition which comprises an isothiazolone compound, suppresses decomposition of the isothiazolone compound and reduces irritation of skin caused by the isothiazolone compound is provided. The antimicrobial composition comprises an isothiazolone compound represented by general formula [1] or general formula [2] and an aminocarboxylic acid represented by general formula [3] or a derivative thereof.

  本发明提供了一种抗菌组合物，该组合物包含异噻唑啉酮化合物，可抑制异噻唑啉酮化合物的分解并减少异噻唑啉酮化合物对皮肤的刺激。 该抗菌组合物由通式[1]或通式[2]代表的异噻唑酮化合物和通式[3]代表的氨基甲酸酯或其衍生物组成。
• METHOD FOR PURIFICATION OF OLIGOPEPTIDE
  申请人：Kyowa Hakko Bio Co., Ltd.

  公开号：EP2036919A1

  公开（公告）日：2009-03-18

  The present invention provides: a method for purifying an oligopeptide, which comprises a step of contacting a solution comprising the oligopeptide and a neutral amino acid with an ion exchange resin in an effective pH range; the method for purifying an oligopeptide, which comprises (a) a step of passing a solution comprising the oligopeptide and the neutral amino acid through a column packed with an ion exchange resin, and (b) a step of eluting the oligopeptide contacted with the ion exchange resin with an eluting solvent; the above method using a weakly acidic cation exchange resin; the above method using a weakly basic anion exchange resin, etc.

  本发明提供了一种纯化低聚肽的方法，其包括在有效 pH 值范围内将包含低聚肽和中性氨基酸的溶液与离子交换树脂接触的步骤；一种纯化寡肽的方法，其包括(a)将包含寡肽和中性氨基酸的溶液通过装有离子交换树脂的柱的步骤，以及(b)用洗脱溶剂洗脱与离子交换树脂接触的寡肽的步骤；上述方法使用弱酸性阳离子交换树脂；上述方法使用弱碱性阴离子交换树脂等。