1-Methyl-1,6-dihydropyridine-2-carboxylic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 1-Methyl-1,6-dihydropyridine-2-carboxylic acid
• 英文别名: 1-methyl-2H-pyridine-6-carboxylic acid
• 化学式: C₇H₉NO₂
• 分子量: 139.15
• InChiKey: DESCXTNYDRKSAL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  40.5
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Liquid phospholipid-containing compositions for the preparation of pharmaceuticals
  申请人：Aker BioMarine Antarctic AS

  公开号：US10806742B2

  公开（公告）日：2020-10-20

  Current krill oil extracts are liquid at room temperature and include only about 45-55% phospholipids. As the purity of phospholipids increases, the extracts become more viscous, making them difficult to handle and process. The invention mixes these pure materials with viscosity-reducing agents to make them amenable to processes such as encapsulation. Thus the invention retains the useful liquid characteristics of known krill extracts while providing much higher concentrations of phospholipids.

  目前的磷虾油提取物在室温下呈液态，仅含有约 45-55% 的磷脂。随着磷脂纯度的提高，提取物变得更加粘稠，使其难以处理和加工。本发明将这些纯材料与降粘剂混合，使其适合封装等工艺。因此，本发明在提供更高浓度磷脂的同时，还保留了已知磷虾提取物的有用液体特性。
• Capsules containing high doses of krill phospholipids
  申请人：Aker BioMarine Antarctic AS

  公开号：US10960016B2

  公开（公告）日：2021-03-30

  Oral capsules have been dismissed as a dosage form for delivery high dosages of krill phospholipids, but by purifying these to high levels it is indeed possible to use this dosage form to deliver, for example, 700 mg or more phospholipids per capsule.

  口服胶囊一直被认为是无法提供高剂量磷虾磷脂的剂型，但通过将磷虾磷脂提纯到高水平，确实可以使用这种剂型提供磷虾磷脂，例如每粒胶囊可提供 700 毫克或更多磷虾磷脂。
• Phospholipid compositions and their preparation
  申请人：Aker BioMarine Antarctic AS

  公开号：US11020438B2

  公开（公告）日：2021-06-01

  The invention provides improved processes for extracting and preparing polar lipids (in particular, desirable phospholipids) from krill and other biological sources. The inventors have discovered processes through which it is possible to extract phospholipids to give high phospholipid content and a reduction of undesired components.

  本发明提供了从磷虾和其他生物来源中提取和制备极性脂质（特别是理想磷脂）的改良工艺。发明者发现了一种工艺，通过这种工艺可以提取磷脂，使磷脂含量高，并减少不需要的成分。
• COMPOUNDS FOR FLUORESCENCE IMAGING
  申请人：UNIVERSITE DE GENEVE

  公开号：EP2114462A2

  公开（公告）日：2009-11-11
• Compounds for fluorescence imaging
  申请人：UNIVERSITE DE GENEVE

  公开号：EP2114462B1

  公开（公告）日：2013-06-05