4-Pyrrol-1-yloxadiazole

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: 4-Pyrrol-1-yloxadiazole
• 化学式: C₆H₅N₃O
• 分子量: 135.12
• InChiKey: HBGAUSPVVSZRTK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  43.8
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• IMMUNOSUPPRESSIVE EFFECTS OF PTERIDINE DERIVATIVES
  申请人：4 AZA Bioscience nv

  公开号：EP1636232A2

  公开（公告）日：2006-03-22
• US5246914A
  申请人：——

  公开号：US5246914A

  公开（公告）日：1993-09-21
• [EN] IMMUNOSUPPRESSIVE EFFECTS OF PTERIDINE DERIVATIVES<br/>[FR] EFFETS IMMUNOSUPPRESSIFS DE DERIVES DE PTERIDINE
  申请人：4 AZA BIOSCIENCE NV

  公开号：WO2004104005A2

  公开（公告）日：2004-12-02

  Novel poly-substituted pteridinediones (lumazines), and mono- or polysubstituted 2-thiolumazines, 4-thiolumazines or 2,4-dithiolumazines, having disclosed substituents in positions 1, 3, 6 and 7 of the pteridine ring, and pharmaceutically acceptable salts thereof, are useful as biologically active ingredients in preparing pharmaceutical compositions especially for the treatment or prevention of a CNS disorder, a cell proliferative disorder, a viral infection, an immune or auto-immune disorder or a transplant rejection. Combinations of the pteridine derivatives of the invention with an immunosuppressant or immunomodulator drug, an antineoplastic drug or an antiviral agent, providing potential synergistic effects, are also disclosed.