N-naphthalen-2-ylpyrrolidine-2-carboxamide

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-naphthalen-2-ylpyrrolidine-2-carboxamide
• 化学式: C₁₅H₁₆N₂O
• mdl: MFCD12649212
• 分子量: 240.3
• InChiKey: IEZATIIUZVDELT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.266
• 拓扑面积：
  41.1
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• CATALYST FOR ASYMMETRIC HYDROGENATION
  申请人：MAEDA Hironori

  公开号：US20100324338A1

  公开（公告）日：2010-12-23

  This invention aims at providing a catalyst for producing an optically active aldehyde or an optically active ketone, which is an optically active carbonyl compound, by carrying out selective asymmetric hydrogenation of an α,β-unsaturated carbonyl compound, particularly a catalyst which is insoluble in a reaction mixture for obtaining optically active citronellal which is useful as a flavor or fragrance, by carrying out selective asymmetric hydrogenation of citral, geranial or neral; and a method for producing a corresponding optically active carbonyl compound. The invention relates to a catalyst for asymmetric hydrogenation of an α,β-unsaturated carbonyl compound, which comprises a powder of at least one metal selected from metals belonging to Group 8 to Group 10 of the Periodic Table, or a metal-supported substance in which at least one metal selected from metals belonging to Group 8 to Group 10 of the Periodic Table is supported on a support, an optically active cyclic nitrogen-containing compound and an acid.

  这项发明旨在通过对α，β-不饱和羰基化合物进行选择性不对称加氢，特别是通过对柠檬醛、香叶醛或柠檬醛进行选择性不对称加氢，从而提供用作香料或香精的有用的光学活性香茅醛的催化剂，该香茅醛是一种光学活性羰基化合物；以及生产相应的光学活性羰基化合物的方法。该发明涉及一种用于不对称加氢α，β-不饱和羰基化合物的催化剂，其包括来自周期表第8至第10族金属中至少一种金属的粉末，或者至少一种来自周期表第8至第10族金属的金属负载物质，该金属负载在一种支撑物上，还包括光学活性的含氮环化合物和酸。
• [EN] DEPALMITOYLATING COMPOSITIONS AND THE USE THEREOF<br/>[FR] COMPOSITIONS DE DÉPALMITYLATION ET LEUR UTILISATION
  申请人：UNIV CALIFORNIA

  公开号：WO2021030703A1

  公开（公告）日：2021-02-18

  Disclosed herein, inter alia, are depalmitoylating compounds, compositions, and methods of use thereof.

  本文披露了脱棕榈酰化化合物、组合物及其使用方法。
• PROCESS FOR PREPARING HALOGENATED CYCLOPROPANE DERIVATIVES
  申请人：DAIICHI PHARMACEUTICAL CO., LTD.

  公开号：US20010051750A1

  公开（公告）日：2001-12-13

  A process for preparing compounds represented by the following general formula (I) wherein X represents chlorine atom or other and R represents alkoxy group, amino group or other, which comprises the step of allowing a compound represented by the formula: CH 2 ═CXF react with a compound represented by the formula: N 2 CHCOR in the presence of a catalyst containing a metal atom such as a transition metal of group 8 together with chiral carboxylic-type or amide-type ligands to preferentially obtain a stereoisomer of the compound of the general formula (I) wherein the stereochemical configuration at the 1-position is S-configuration 1

  一种制备以下通式（I）所代表化合物的方法，其中X代表氯原子或其他，R代表烷氧基，氨基或其他，包括以下步骤：在存在包含金属原子的催化剂的条件下，使通式为CH2═CXF的化合物与通式为N2CHCOR的化合物反应，该催化剂包含第8族过渡金属以及手性羧酸型或酰胺型配体，以优先获得具有S构型的通式（I）化合物的立体异构体，其中1-位的立体化学配置为S构型1。
• PROCESS FOR PRODUCING HALOGENATED CYCLOPROPANE DERIVATIVES
  申请人：DAIICHI PHARMACEUTICAL CO., LTD.

  公开号：EP0858992B1

  公开（公告）日：2001-12-12
• DEPALMITOYLATING COMPOSITIONS AND THE USE THEREOF
  申请人：The Regents of the University of California

  公开号：EP4013498A1

  公开（公告）日：2022-06-22