Microbial process for producing L-ascorbic acid, D-erythorbic acid, and salts thereof
申请人:ROCHE VITAMINS INC.
公开号:US20030105160A1
公开(公告)日:2003-06-05
A process for producing L-ascorbic acid or D-erythorbic acid, or in each case its sodium, potassium or calcium salt, from 2-keto-L-gulonic acid or 2-keto-D-gluconic acid, or in each case its sodium, potassium or calcium salt, that involves incubating 2-keto-L-gulonic acid or 2-keto-D-gluconic acid, each as the free acid or as its sodium, potassium or calcium salt, and the cells of a thermoacidophilic microorganism at temperatures from about 30° C. to about 100° C., and at a pH from about 1 to about 6, in a solution, to form L-ascorbic acid or D-erythorbic acid or an appropriate salt thereof, and isolating said product from the solution.
一种生产L-抗坏血酸或D-赤藓糖酸,或在每种情况下其钠、钾或钙盐的方法,从2-酮基-L-古龙糖酸或2-酮基-D-葡萄糖酸,或在每种情况下其钠、钾或钙盐,其中包括将2-酮基-L-古龙糖酸或2-酮基-D-葡萄糖酸,作为游离酸或其钠、钾或钙盐,与热酸性微生物的细胞在pH为1到6之间的溶液中孵育,在温度从大约30℃到大约100℃之间,形成L-抗坏血酸或D-赤藓糖酸或其适当的盐,并从溶液中分离出该产品的过程。