7-hydroxy-4-(2-oxochromen-3-yl)chromen-2-one

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: 7-hydroxy-4-(2-oxochromen-3-yl)chromen-2-one
• 英文别名: 7'-hydroxy-[3,4']bichromenyl-2,2'-dione；7'-Hydroxy-[3,4']bichromenyl-2,2'-dion
• 化学式: C₁₈H₁₀O₅
• 分子量: 306.274
• InChiKey: AAFQUFFWQFQGDH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  23
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  72.8
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  1-甲基-4-[(4-甲基哌嗪-1-基)甲基]哌嗪 、 7-hydroxy-4-(2-oxochromen-3-yl)chromen-2-one 以 1,4-二氧六环 为溶剂， 以82%的产率得到7-Hydroxy-8-[(4-methylpiperazin-1-yl)methyl]-4-(2-oxochromen-3-yl)chromen-2-one
  参考文献：
  名称：

  Chemistry of 3-hetarylcoumarins 3*. Synthesis and aminomethylation of 7′-hydroxy-3,4′- bicoumarins

  摘要：

  An improved procedure for the synthesis of 7'-hydroxy-3,4'-bicoumarins has been developed. Their 8'-aminomethyl derivatives were obtained by interaction with aminals.

  DOI：

  10.1007/s10593-012-1009-z
• 作为产物：
  描述：

  7-acetoxy-4-(2-oxochromen-3-yl)chromen-2-one 在 ammonium hydroxide 作用下， 反应 18.0h， 以82%的产率得到7-hydroxy-4-(2-oxochromen-3-yl)chromen-2-one
  参考文献：
  名称：

  Modified coumarins. 14. Synthesis of 7-hydroxy-[4,3?]dichromenyl-2,2?-dione derivatives

  摘要：

  新衍生物3-(2-氧基香豆素-4-基)香豆素-2-酮是从取代的香豆酸-4-乙酸中制备的，属于天然双香豆素的改性类似物。

  DOI：

  10.1007/s10600-005-0006-1

文献信息

• SMALL COMPOUND TARGETING AT TACC3
  申请人：Japanese Foundation For Cancer Research

  公开号：EP2857392B1

  公开（公告）日：2018-06-13
• Dey; Row, Journal of the Indian Chemical Society, 1923, vol. 1, p. 117
  作者：Dey、Row

  DOI：——

  日期：——
• AGENT FOR PROMOTING OSTEOBLAST DIFFERENTIATION, PHARMACEUTICAL COMPOSITION FOR PROMOTING BONE FORMATION, AND FOOD FOR SPECIAL DIETARY USE CONTAINING AURAPTENE ANALOG AS ACTIVE INGREDIENT
  申请人：Woo Je-Tae

  公开号：US20130102796A1

  公开（公告）日：2013-04-25

  Agents or pharmaceutical compositions for promoting osteoblast differentiation include purified auraptene or coumarin analogs thereof represented by the following formula 1: wherein R1 represents a hydrogen, a hydroxy, a methoxy, a methyl, an ethyl, a propyl, a carboxyl, a carboxymethyl, or a carboxyethyl; R2 represents a hydrogen, a hydroxy, a methoxy, a methyl, an ethyl, a propyl, a carboxyl, a carboxymethyl, a carboxyethyl or a coumarinyl; R3 represents a hydrogen, a hydroxy, a methoxy, a methyl, an ethyl, a propyl, a carboxyl, a carboxymethyl or a carboxyethyl; and R4 represents a hydrogen, a C 1 -C 15 liner or branched alkyl, an alkenyl, an alkadienyl or an alkatrienyl.
• SMALL COMPOUNDS TARGETING TACC3
  申请人：JAPANESE FOUNDATION FOR CANCER RESEARCH

  公开号：US20150111888A1

  公开（公告）日：2015-04-23

  The present invention provides a small compound targeting at TACC3. The present invention further provides a drug, particularly, an anticancer agent, comprising the small compound targeting at TACC3. A compound represented by the general formula (I) or a pharmaceutically acceptable salt, solvate, or ester derivative thereof binds to TACC3 and inhibits cell growth. Thus, these compounds can be used as drugs, particularly, anticancer agents.
• US8729279B2
  申请人：——

  公开号：US8729279B2

  公开（公告）日：2014-05-20