histidin-ethyl ester | 7555-06-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: histidin-ethyl ester
• 英文别名: Histidin-aethylester；Ethyl 2-amino-3-(1H-imidazol-5-yl)propanoate
• CAS: 7555-06-8
• 化学式: C₈H₁₃N₃O₂
• mdl: MFCD06796162
• 分子量: 183.21
• InChiKey: ACHWEOLUTJAHLV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  13
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  81
• 氢给体数：
  2
• 氢受体数：
  4

安全信息

• 海关编码：
  2933290090

反应信息

• 作为反应物：
  描述：

  histidin-ethyl ester 生成 alkaline earth salt of/the/ methylsulfuric acid
  参考文献：
  名称：

  Pauly, Hoppe-Seyler's Zeitschrift fur Physiologische Chemie, 1910, vol. 64, p. 78

  摘要：

  DOI：

文献信息

• [EN] THIOSEMICARBAZATES AND USES THEREOF<br/>[FR] THIOSEMICARBAZATES ET LEURS UTILISATIONS
  申请人：FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH

  公开号：WO2020227592A1

  公开（公告）日：2020-11-12

  Thioesters, thiocarbamates, thiocarbazates, semithiocarbazates, peptides, aza-amino acid conjugates, and azapeptides; and a chemoselective and site-specific functionalization protocol of protected thiocarbazates and semithiocarbazates are described. The protocol features the use of Mitsunobu reaction to alkylate specifically the nitrogen atom close to the acylthiol moiety with alcohols to produce protected mono-substituted thiocarbazates that can be stored for months, activated under mild conditions at low temperature using halonium reagents and integrated orthogonally to make substituted semicarbazides that can be used, e.g., as synthons in synthesis of aza-amino acid conjugates, azapeptides and other peptidomimetics. Methods for preparing and using ureases, carbazides, semicarbazides, beta-peptides, azapeptides, and other peptidomimetics and azapeptide conjugates, and uses of ureases, carbazides, semicarbazides, beta-peptides, azapeptides in drug discovery, diagnosis, inhibition, prevention and treatment of diseases are also described.

  巯酯，硫代氨基甲酸酯，硫代氨基甲酸酯，半硫代氨基甲酸酯，肽，氮代氨基酸共轭物和氮代肽；以及一种对受保护的硫代氨基甲酸酯和半硫代氨基甲酸酯进行化学选择性和位点特异性功能化的方法被描述。该方法采用三甲基脲反应特异性烷基化靠近酰硫醇基团的氮原子，使用醇生成可储存数月的受保护的单取代硫代氨基甲酸酯，在低温下使用卤化物试剂轻微条件下激活，并与其他基团正交集成以制备取代半氨基甲酸酰胺，例如，可用作氮代氨基酸共轭物，氮代肽和其他肽类模拟物的合成中间体。还描述了制备和使用尿酶，卡巴酰胺，半氨基甲酸酰胺，β-肽，氮代肽和其他肽类模拟物以及氮代肽共轭物的方法，以及尿酶，卡巴酰胺，半氨基甲酸酰胺，β-肽，氮代肽在药物发现，诊断，抑制，预防和治疗疾病中的用途。
• Polyglutamic Acids Functionalised by Histidine Derivatives and Hydrophobic Groups and the Uses Thereof, in Particular for Therapeutic Purposes
  申请人：Soula Olivier

  公开号：US20100034886A1

  公开（公告）日：2010-02-11

  The invention relates to novel biodegradable materials based on modified polyamino acids and suitable, in particular, for vectoring active substance(s) (AS). Said invention also relates to novel pharmaceutical, cosmetic, dietary or plant protective compositions which are based on said polyamino acids. The aim of said invention is to provide a novel polymer raw material usable for vectoring the AS and capable to optimally meet all specification in this area: biocompatibility, biodegradability, ability to become easily associated with many active substances or to solubilise them and to release said active substances in vivo. The aim is attained to 30 carbon atoms. Said polyglutamates modified by histidine derivatives are soluble with pH lower than 5 and are easily and economically convertible into active substance vectorization particles which are able to form stable aqueous colloidal suspensions. On the contrary, said modified polyglutamates are insoluble in water with a physiological pH (7.4), and thereby have to be precipitated on an injection site in the case of a subcutaneous injection.

  该发明涉及基于改性聚氨基酸的新型可生物降解材料，特别适用于载荷活性物质（AS）。该发明还涉及基于这些聚氨基酸的新型药用、化妆品、膳食或植物保护组合物。 该发明的目的是提供一种新型聚合物原料，可用于载荷AS，并能够最佳地满足该领域的所有规范要求：生物相容性、生物降解性、能够轻松与许多活性物质结合或溶解它们，并在体内释放所述活性物质。该目的在30个碳原子处实现。 通过组氨酸衍生物改性的聚谷氨酸在pH低于5时可溶解，并且可以经济地转化为能够形成稳定水性胶体悬浮液的活性物质载体颗粒。相反，这些改性聚谷氨酸在生理pH值（7.4）下不溶于水，因此在皮下注射时必须在注射部位沉淀。
• [EN] AMINO ACID AND PEPTIDE CONJUGATES OF ARYLALKYLIC ACIDS FOR COSMETIC USE<br/>[FR] AMINOACIDE ET PEPTIDE CONJUGUÉS D'ACIDE ARYL-ALKYLE DESTINES A ETRE UTILISES EN COSMETIQUE
  申请人：DSM IP ASSETS BV

  公开号：WO2005092850A1

  公开（公告）日：2005-10-06

  The invention provides novel compounds of general formula (I), wherein R1, R2 and R3 are independently hydrogen, OR4, C1-C6 alkyl or C2-C6 alkenyl, R4 is hydrogen, C1-C6 alkyl or C2-C6 alkenyl, -N-(AA) represents the residue of an amino acid or of a peptide which is bonded over the N-terminus of the amino acid or the peptide and the peptide is composed of 2 to 6, that means 2, 3, 4, 5 or 6, amino acids, wherein the C-terminus of the amino acid or the peptide is optionally esterified with a C1-C16 hydrocarbon moiety and n is an integer of 1 to 5. The compounds are in particular useful for cosmetic applications.

  该发明提供了一般式（I）的新化合物，其中R1、R2和R3分别是氢、OR4、C1-C6烷基或C2-C6烯基，R4是氢、C1-C6烷基或C2-C6烯基，-N-(AA)代表氨基酸或肽的残基，该残基与氨基酸或肽的N-末端结合，该肽由2至6个氨基酸组成，即2、3、4、5或6个氨基酸，其中氨基酸或肽的C-末端可以选择性地与C1-C16烃基酯化，n是1至5的整数。这些化合物特别适用于化妆品应用。
• Potential Antineoplastic Agents: N-(2-Benzoxazolyl)amino Acid Esters
  作者：Shyam B. Advani、Joseph Sam

  DOI：10.1002/jps.2600571013

  日期：1968.10

  The investigation of the preparation of N-(2-benzoxazolyl)aminoacids and esters from the reaction of aminoacids and esters with either 2-chlorobenzoxazole or 2-benzoxazolinone is described.

  描述了由氨基酸和酯与2-氯苯并恶唑或2-苯并恶唑啉酮反应制备N-（2-苯并恶唑基）氨基酸和酯的研究。
• Bifunctionalized polysaccharides
  申请人：Soula Gerard

  公开号：US20080014250A1

  公开（公告）日：2008-01-17

  The present invention relates to a dextran and/or dextran derivative bifunctionalized by at least one imidazolyl radical Im and at least one hydrophobic group Hy, the said radical and the said group being each identical and/or different and grafted or bonded to the dextran and/or dextran derivative via one or more connecting arms R, Ri or Rh and functional groups F, Fi or Fh and the pharmaceutical compositions comprising one of the said dextrans and at least one active principle.

  本发明涉及一种由至少一个咪唑基团Im和至少一个疏水基团Hy双官能化的葡聚糖和/或葡聚糖衍生物，所述基团和所述基团各自相同和/或不同，并通过一个或多个连接臂R、Ri或Rh和功能基团F、Fi或Fh嫁接或结合到葡聚糖和/或葡聚糖衍生物上，并且所述药物组合物包括所述葡聚糖之一和至少一个活性成分。