S-{1-[5-(6-Amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)oxolan-2-yl]-3,5,9-trihydroxy-8,8-dimethyl-3,5,10,14-tetraoxo-2,4,6-trioxa-11,15-diaza-3lambda~5~,5lambda~5~-diphosphaheptadecan-17-yl} 2-methylpropanethioate

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: S-{1-[5-(6-Amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)oxolan-2-yl]-3,5,9-trihydroxy-8,8-dimethyl-3,5,10,14-tetraoxo-2,4,6-trioxa-11,15-diaza-3lambda~5~,5lambda~5~-diphosphaheptadecan-17-yl} 2-methylpropanethioate
• 英文别名: S-[2-[3-[[4-[[[5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] 2-methylpropanethioate
• 化学式: C₂₅H₄₂N₇O₁₇P₃S
• 分子量: 837.6
• InChiKey: AEWHYWSPVRZHCT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -4.6
• 重原子数：
  53
• 可旋转键数：
  21
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.68
• 拓扑面积：
  389
• 氢给体数：
  9
• 氢受体数：
  22

文献信息

• Producing 3-hydroxycarboxylic acid and ketone using polyketide synthases
  申请人：The Regents of the University of California

  公开号：US10233431B2

  公开（公告）日：2019-03-19

  The present invention provides for a polyketide synthase (PKS) capable of synthesizing a 3-hydroxycarboxylic acid or ketone. The present invention also provides for a host cell comprising the PKS and when cultured produces the 3-hydroxycarboxylic acid or ketone.

  本发明提供了一种能够合成3-羟基羧酸或酮的聚酮合酶（PKS）。本发明还提供了一种包含该PKS的宿主细胞，当培养时产生3-羟基羧酸或酮。
• PROCESS FOR THE BIOLOGICAL PRODUCTION OF METHACRYLIC ACID AND DERIVATIVES THEREOF
  申请人：Lucite International UK Limited

  公开号：US20180171368A1

  公开（公告）日：2018-06-21

  A process of producing methacrylic acid and/or derivatives thereof including the following steps: (a) biologically converting isobutyryl-CoA into methacrylyl-CoA by the action of an oxidase; and (b) converting methacrylyl-CoA into methacrylic acid and/or derivatives thereof. The invention also extends to microorganisms adapted to conduct the steps of the process.

  一种生产甲基丙烯酸及/或其衍生物的方法，包括以下步骤：(a)通过氧化酶的作用将异丁酰辅酶A转化为甲基丙烯酰辅酶A；(b)将甲基丙烯酰辅酶A转化为甲基丙烯酸及/或其衍生物。该发明还涉及适于进行该方法步骤的微生物。
• METHOD FOR PRODUCING METHACRYLIC ACID ESTER
  申请人：Mitsubishi Rayon Co., Ltd.

  公开号：US20150184207A1

  公开（公告）日：2015-07-02

  Provided is a method for producing a methacrylic acid ester using a biocatalyst, said method comprising a step for treating methacrylyl-CoA with an alcohol or phenol in the presence of an alcohol acyltransferase to synthesize the methacrylic acid ester. According to this production method, a methacrylic acid ester can be efficiently produced while largely reducing energy, resource and environmental load, compared with the conventional chemical production processes.

  提供了一种使用生物催化剂生产甲基丙烯酸酯的方法，该方法包括在醇酰转移酶的存在下，将甲基丙烯酰辅酶A与醇或酚处理以合成甲基丙烯酸酯的步骤。根据这种生产方法，与传统的化学生产工艺相比，可以在很大程度上减少能源、资源和环境负荷的情况下高效地生产甲基丙烯酸酯。
• Producing 3-Hydroxycarboxylic Acid and Ketone Using Polyketide Synthases
  申请人：The Regents of the University of California

  公开号：US20150307855A1

  公开（公告）日：2015-10-29

  The present invention provides for a polyketide synthase (PKS) capable of synthesizing a 3-hydroxycarboxylic acid or ketone. The present invention also provides for a host cell comprising the PKS and when cultured produces the 3-hydroxycarboxylic acid or ketone.

  本发明提供了一种能够合成3-羟基羧酸或酮的聚酮合酶（PKS）。本发明还提供了一种包含PKS的宿主细胞，当培养时可产生3-羟基羧酸或酮。
• ORGANISMS FOR THE PRODUCTION OF ISOPROPANOL, n-BUTANOL, AND ISOBUTANOL
  申请人：Burgard Anthony P.

  公开号：US20100323418A1

  公开（公告）日：2010-12-23

  A non-naturally occurring microbial organism having an isopropanol pathway includes at least one exogenous nucleic acid encoding an isopropanol pathway enzyme. The pathway includes an enzyme selected from a 4-hydroxybutyryl-CoA dehydratase, a crotonase, a 3-hydroxybutyryl-CoA dehydrogenase, an acetoacetyl-CoA synthetase, an acetyl-CoA:acetoacetate-CoA transferase, an acetoacetyl-CoA hydrolase, an acetoacetate decarboxylase, and an acetone reductase. A non-naturally occurring microbial organism having an n-butanol pathway includes at least one exogenous nucleic acid encoding an n-butanol pathway enzyme. Other non-naturally occurring microbial organism have n-butanol or isobutanol pathways. The organisms are cultured to produce isopropanol, n-butanol, or isobutanol.

  具有异丙醇途径的非自然微生物生物体包括至少一种外源核酸，编码异丙醇途径酶。途径包括从4-羟基丁酰辅酶A脱水酶、丙烯酰辅酶A环化酶、3-羟基丁酰辅酶A脱氢酶、乙酰乙酰辅酶A合成酶、乙酰辅酶A：乙酰乙酸辅酶A转移酶、乙酰乙酰辅酶A水解酶、乙酰乙酸盐脱羧酶和丙酮还原酶中选择的酶。具有正丁醇途径的非自然微生物生物体包括至少一种外源核酸，编码正丁醇途径酶。其他非自然微生物生物体具有正丁醇或异丁醇途径。这些生物体被培养以生产异丙醇、正丁醇或异丁醇。