5,12,18-Trihydroxyicosa-6,8,10,14,16-pentaenoic acid

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 5,12,18-Trihydroxyicosa-6,8,10,14,16-pentaenoic acid
• 英文别名: 5,12,18-trihydroxyicosa-6,8,10,14,16-pentaenoic acid
• 化学式: C₂₀H₃₀O₅
• 分子量: 350.4
• InChiKey: AOPOCGPBAIARAV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  25
• 可旋转键数：
  13
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  98
• 氢给体数：
  4
• 氢受体数：
  5

文献信息

• [EN] COMPOSITIONS AND METHODS RELATING TO SALTS OF SPECIALIZED PRO-RESOLVING MEDIATORS OF INFLAMMATION<br/>[FR] COMPOSITIONS ET PROCÉDÉS RELATIFS À DES SELS DE MÉDIATEURS SPÉCIALISÉS DE PRO-RÉSOLUTION D'INFLAMMATION
  申请人：THETIS PHARMACEUTICALS LLC

  公开号：WO2017210604A1

  公开（公告）日：2017-12-07

  The present invention relates to compounds of Formulas I-IV, which are salts of special lipid mediators of inflammation, compositions containing same, and methods of using same in the treatment of various diseases and disorders characterized by chronic or excessive inflammation, or both.

  本发明涉及公式I-IV的化合物，它们是炎症特殊脂质介质的盐，包括含有它们的组合物，并且在治疗由慢性或过度炎症或两者都特征的各种疾病和障碍中使用它们的方法。
• CMKLR1 AGONISTS HAVING A RESOLVIN E1-LIKE CAPABILITY AND THEIR THERAPEUTIC APPLICATIONS
  申请人：OSE Immunotherapeutics

  公开号：EP3804754A1

  公开（公告）日：2021-04-14

  The present invention provides anti-chemerin receptor antibodies which have a resolvin E1-like agonist activity on chemokine like receptor-1 (CMKLR1) for use in the resolution of an inflammation occurring during autoimmune diseases, chronic inflammatory diseases, infectious diseases, cancers, by sustaining or initiating the resolution phase of inflammation.

  本发明提供了对趋化因子样受体-1（CMKLR1）具有类似 resolvin E1 激动剂活性的抗hemerin 受体抗体，用于通过维持或启动炎症的消解阶段来消解自身免疫性疾病、慢性炎症性疾病、传染性疾病、癌症期间发生的炎症。
• COMPOSITIONS AND METHODS RELATING TO SALTS OF SPECIALIZED PRO-RESOLVING MEDIATORS OF INFLAMMATION
  申请人：Thetis Pharmaceuticals LLC

  公开号：EP3454907A1

  公开（公告）日：2019-03-20
• COMPOSITIONS AND METHODS RELATING TO SALTS OF SPECIALIZED PRO-RESOLVING MEDIATORS
  申请人：Thetis Pharmaceuticals LLC

  公开号：EP3717451A1

  公开（公告）日：2020-10-07