1,3,4,5-tetraacetoxycyclohexane carboxylic acid | 23804-28-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 1,3,4,5-tetraacetoxycyclohexane carboxylic acid
• 英文别名: Cyclohexanecarboxylic acid, 1,3,4,5-tetrahydroxy-, tetraacetate, stereoisomer；1,3,4,5-tetraacetyloxycyclohexane-1-carboxylic acid
• CAS: 23804-28-6；32469-24-2；62445-00-5
• 化学式: C₁₅H₂₀O₁₀
• 分子量: 360.318
• InChiKey: AQDXBJGFGAIZBE-UHFFFAOYSA-N

物化性质

• 沸点：
  441.1±45.0 °C(Predicted)
• 密度：
  1.35±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  25
• 可旋转键数：
  9
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  143
• 氢给体数：
  1
• 氢受体数：
  10

文献信息

• Novel quercetin derivatives, their preparation, pharmaceutical compositions containing them and their use
  申请人：Bel/Novamann International s.r.o.

  公开号：EP2468741A1

  公开（公告）日：2012-06-27

  The invention relates to novel quercetin derivatives and pharmaceutically acceptable salts, hydrates, and solvates and dimers thereof; a process for the preparation of the novel quercetin derivatives and pharmaceutically acceptable salts, hydrates, and solvates and dimers thereof; and pharmaceutical compositions comprising the same that are useful for the treatment of various disorders. The quercetin derivatives are shown by formula I and II.

  该发明涉及新型槲皮素衍生物及其药用可接受的盐、水合物、溶剂合物和二聚体；一种制备新型槲皮素衍生物及其药用可接受的盐、水合物、溶剂合物和二聚体的方法；以及包含这些物质的药物组合物，用于治疗各种疾病。槲皮素衍生物的结构由化学式I和II表示。
• [EN] NOVEL CATIONIC AMPHIPHILES WITH MANNOSE-MIMICKING HEAD-GROUPS AND A PROCESS FOR THE PREPARATION THEREOF<br/>[FR] NOUVEAUX AMPHIPHILES CATIONIQUES À TÊTES POLAIRES IMITANT LA MANNOSE, ET LEURS MÉTHODES DE PRÉPARATION
  申请人：COUNCIL SCIENT IND RES

  公开号：WO2012035557A1

  公开（公告）日：2012-03-22

  The present invention discloses novel cationic amphiphiles containing mannose-mimicking shikimic and quinic acid head-groups and a process for preparing cationic amphiphiles with mannose-mimicking polar head-groups such as, shikimic and quinic acids. The findings described herein also demonstrate that compounds of the present invention can target model DNA vaccines to antigen presenting cells (APCs) such as macrophages and dendritic cells (DCs), via mannose receptors expressed on the cell surface of APCs. The cationic amphiphiles disclosed herein show enhanced cellular and humoral immune response compared to their mannosyl counterpart in dendritic cell (DC, the most professional APC) based genetic immunization in mice. Cationic amphiphiles with mannose-mimicking quinic and shikic acid head-groups described in the present invention are likely to find future applications in the field of genetic immunization.

  本发明公开了包含类似于甘露糖的樟脑酸和奎尼酸头基的新型阳离子两性分子，以及一种制备具有类似于甘露糖极性头基的阳离子两性分子（如樟脑酸和奎尼酸）的方法。本文描述的研究结果还表明，本发明的化合物可以通过APC（抗原呈递细胞）如巨噬细胞和树突状细胞表面上表达的甘露糖受体，将模型DNA疫苗定位到目标细胞。与其甘露基对照相比，本文披露的阳离子两性分子在小鼠基因免疫中表现出更强的细胞和体液免疫应答。本发明中描述的具有类似于甘露糖的奎尼酸和樟脑酸头基的阳离子两性分子可能在基因免疫领域找到未来的应用。
• NOVEL CATIONIC AMPHIPHILES WITH MANNOSE-MIMICKING HEAD-GROUPS AND A PROCESS FOR THE PREPARATION THEREOF
  申请人：Council of Scientific & Industrial Research

  公开号：EP2616431A1

  公开（公告）日：2013-07-24
• MANNOSE-RECEPTOR SELECTIVE LYSINYLATED CATIONIC AMPHIPHILES AND A PROCESS FOR PREPARATION THEREOF
  申请人：Council of Scientific & Industrial Research

  公开号：EP2941435B1

  公开（公告）日：2021-06-16
• Mannose-Receptor Selective Lysinylated Cationic Amphiphiles and a Process for Preparation Thereof
  申请人：COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH

  公开号：US20150337000A1

  公开（公告）日：2015-11-26

  The present invention relates to the mannose-receptor selective lysinylated cationic amphiphile and a process for preparation thereof. The compounds of the present invention can target DNA vaccines to antigen presenting cells (APCs) such as macrophages and dendritic cells (DCs), via mannose receptors expressed on the cell surface of APCs. The cationic amphiphiles disclosed herein show enhanced cellular and humoral immune response compared to their mannosyl counterparts in genetic immunization in mice. The present invention discloses that immunization with electrostatic complexes (lipoplexes) of DNA vaccines encoding melanoma antigens (gp100 and tyrosinase) and liposome of the presently described novel lysinylated cationic amphiphiles with mannose-mimicking shikimoyl head-groups provides long-lasting (100 days post melanoma tumor challenge) protective immunity in all immunized mice. Cationic amphiphiles with mannose-mimicking shikimoyl head-groups described in the present invention are likely to find future applications in the field of genetic immunization.