N-(4-Methoxy-2,6-bis-methylamino-pyrimidin-5-yl)-N-methyl-formamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: N-(4-Methoxy-2,6-bis-methylamino-pyrimidin-5-yl)-N-methyl-formamide
• 英文别名: Heteromine G；N-[4-methoxy-2,6-bis(methylamino)pyrimidin-5-yl]-N-methylformamide
• 化学式: C₉H₁₅N₅O₂
• 分子量: 225.25
• InChiKey: AYPVLECRVLOFKA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  79.4
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  6-Methoxy-7,9-dimethyl-2-methylamino-9H-purin-7-ium; chloride 在 ammonium hydroxide 作用下， 反应 3.0h， 以25 mg的产率得到N-(4-Methoxy-2,6-bis-methylamino-pyrimidin-5-yl)-N-methyl-formamide
  参考文献：
  名称：

  Two New Puriniums and Three New Pyrimidines from Heterostemma brownii

  摘要：

  Two new puriniums, heteromines D (4) and E (5), and three new pyrimidines, heteromines F (6), G (7), and H (8), were isolated from the aerial parts of Heterostemma brownii Hay. Their structures were determined as 7,9-dimethyl-2-(N,N-dimethylamino)guaninium chloride, 7,9-dimethyl-2-(N-methylamino)guaninium chloride, 6-methoxy-4-(N-methylamino)-2-(N,N-dimethylamino)-5-(N-methylformamido)pyrimidine, 6-methoxy-2,4-bis(N-methylamino)-5-(N-methylformamido)pyrimidine, and 2-amino-6-methoxy-4-(N-methylamino)-5-(N-methylformamido)pyrimidine, respectively.

  DOI：

  10.1021/np970159y

文献信息

• Two New Puriniums and Three New Pyrimidines from <i>Heterostemma brownii</i>
  作者：Yun-Lian Lin、Ray-Ling Huang、Chung-Ming Chang、Yueh-Hsiung Kuo

  DOI：10.1021/np970159y

  日期：1997.10.1

  Two new puriniums, heteromines D (4) and E (5), and three new pyrimidines, heteromines F (6), G (7), and H (8), were isolated from the aerial parts of Heterostemma brownii Hay. Their structures were determined as 7,9-dimethyl-2-(N,N-dimethylamino)guaninium chloride, 7,9-dimethyl-2-(N-methylamino)guaninium chloride, 6-methoxy-4-(N-methylamino)-2-(N,N-dimethylamino)-5-(N-methylformamido)pyrimidine, 6-methoxy-2,4-bis(N-methylamino)-5-(N-methylformamido)pyrimidine, and 2-amino-6-methoxy-4-(N-methylamino)-5-(N-methylformamido)pyrimidine, respectively.