1-(4-hydroxy-3-methoxy-phenyl)-propane-1,2-dione | 2034-60-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 1-(4-hydroxy-3-methoxy-phenyl)-propane-1,2-dione
• 英文别名: Vanilloyl-methyl-keton；1-<4-Hydroxy-3-methoxy-phenyl>-propandion-(1,2)；1-(4-Hydroxy-3-methoxyphenyl)propane-1,2-dione
• CAS: 2034-60-8
• 化学式: C₁₀H₁₀O₄
• 分子量: 194.187
• InChiKey: BCUDLMOGCPZQHY-UHFFFAOYSA-N

物化性质

• 熔点：
  72-73 °C
• 沸点：
  125 °C(Press: 0.2 Torr)
• 密度：
  1.236±0.06 g/cm3(Predicted)
• 保留指数：
  1588.5

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  63.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1-(4-hydroxy-3-methoxy-phenyl)-propane-1,2-dione 在 sodium hydroxide 、 sodium 3-nitrobenzenesulfonate 作用下， 生成 2-(4-羟基-3-甲氧基苯基)-2-氧代乙酸
  参考文献：
  名称：

  �ber das Verhalten von markiertem Coniferin in der verholzenden Pflanze

  摘要：

  DOI：

  10.1007/bf00905395
• 作为产物：
  描述：

  香草基扁桃酸乙酯 在 吡啶 、 盐酸 、 sodium hydroxide 、 氯化亚砜 、 乙醚 、 溶剂黄146 、 苯 作用下， 生成 1-(4-hydroxy-3-methoxy-phenyl)-propane-1,2-dione
  参考文献：
  名称：

  Studies on Lignin and Related Compounds. LXXXII. Synthesis and Properties of 1,3-Diacetoxy-1-(4-acetoxy-3-methoxyphenyl)-2-propanone and 1-Acetoxy-3-chloro-1-(4-acetoxy-3-methoxyphenyl)-2-propanone and their Relation to Lignin Structure¹

  摘要：

  DOI：

  10.1021/ja01232a029

文献信息

• NOVEL BENZOFURAN TYPE DERIVATIVES, A COMPOSITION COMPRISING THE SAME FOR TREATING OR PREVENTING COGNITIVE DYSFUNCTION AND THE USE THEREOF
  申请人：Kang Dong Wook

  公开号：US20100197685A1

  公开（公告）日：2010-08-05

  The present invention relates to the novel benzofuran derivatives, the preparation thereof and the composition comprising the same. The benzofuran derivatives of the present invention showed potent inhibiting activity of beta-amyloid aggregation and cell cytotoxicity resulting in stimulating the proliferation of neuronal cells as well as recovering activity of memory learning injury caused by neuronal cell injury using transformed animal model with beta-amyloid precursor gene, therefore the compounds can be useful in treating or preventing cognitive function disorder.

  本发明涉及新型苯并呋喃衍生物，其制备方法以及包含该衍生物的组合物。本发明的苯并呋喃衍生物显示出强大的β-淀粉样蛋白聚集抑制活性和细胞毒性，从而刺激神经细胞的增殖，并恢复由神经细胞损伤引起的记忆学习损伤的活性，使用带有β-淀粉样前体基因的转化动物模型，因此这些化合物可用于治疗或预防认知功能障碍。
• [EN] NOVEL ZWITTERIONIC FLUORESCENT DYES FOR LABELING IN PROTEOMIC AND OTHER BIOLOGICAL ANALYSES<br/>[FR] NOUVEAUX COLORANTS ZWITTERIONIQUES FLUORESCENTS POUR LE MARQUAGE EN PROTEOMIQUE ET AUTRES ANALYSES BIOLOGIQUES
  申请人：UNIV MONTANA STATE

  公开号：WO2004009598A1

  公开（公告）日：2004-01-29

  The invention relates to compositions and methods useful in the labeling and identification of proteins. The invention provides for highly soluble zwitterionic dye molecules where the dyes and associated side groups are non-titratable and maintain their net zwitterionic character over a broad pH range, e.g. between pH 3 and 12. These dye molecules find utility in a variety of applications, including use in the field of proteomics.

  本发明涉及用于蛋白质标记和鉴定的有用的组合物和方法。本发明提供了一种高度可溶的两性离子染料分子，其中染料和相关侧链不具可滴定性，在广泛的pH范围内保持其净两性离子特性，例如在pH 3到12之间。这些染料分子在多种应用中具有实用价值，包括在蛋白质组学领域的使用。
• 1H-pyrrole-2,4-dicarbonyl-derivatives and their use as flavoring agents
  申请人：IMAX Discovery GmbH

  公开号：EP2832233A1

  公开（公告）日：2015-02-04

  The present invention primarily relates to 1H-pyrrole-2,4-dicarbonyl-derivatives of Formula (I) wherein R1, R2, R3, Z. Z' and J are as defined in the description, to mixtures thereof and to the use thereof as flavoring agents. The compounds in accordance with the present invention are suitable for producing, imparting, or intensifying an umami flavor. The invention further relates to flavoring mixtures, compositions for oral consumption as well as ready-to-eat, ready-to-use and semifinished products, comprising an effective amount of the compound of Formula (I) or of a mixture of compounds of Formula (I) and to specific methods for producing, imparting, modifying and/or intensifying specific flavor impressions.

  本发明主要涉及式(I)的1H-吡咯-2,4-二羰基衍生物，其中R1、R2、R3、Z、Z'和J按描述定义，及其混合物，以及用作调味剂的使用。根据本发明的化合物适用于生产、赋予或增强鲜味。本发明进一步涉及包含式(I)化合物或式(I)化合物混合物的有效量的调味混合物、口腔消费的组成物以及即食、即用和半成品，以及用于生产、赋予、改变和/或增强特定风味印象的特定方法。
• Imidazo[1,2-a]pyridine-ylmethyl-derivatives and their use as flavoring agents
  申请人：IMAX Discovery GmbH

  公开号：EP2832234A1

  公开（公告）日：2015-02-04

  The present invention primarily relates to imidazo[1,2-a]pyridine-ylmethyl-derivatives of Formula (I) wherein R1, R2, X, W e J are as defined in the description, to mixtures thereof and to the use thereof as flavoring agents. The compounds in accordance with the present invention are suitable for producing, imparting, or intensifying an umami flavor. The invention further relates to flavoring mixtures, compositions for oral consumption as well as ready-to-eat, ready-to-use and semifinished products, comprising an effective amount of the compound of Formula (I) and to specific methods for producing, imparting, modifying and/or intensifying specific flavor impressions.

  本发明主要涉及式(I)的咪唑[1,2-a]吡啶基甲基衍生物，其中R1、R2、X、W和J如描述中定义，以及涉及它们的混合物和使用它们作为调味剂。根据本发明的化合物适合于产生、赋予或增强鲜味。本发明进一步涉及调味混合物、口腔摄入的配方以及包含有效量的式(I)化合物的即食、即用和半成品，以及用于生产、赋予、改变和/或增强特定风味印象的特定方法。
• [EN] DRUG CONJUGATES WITH PHOTOCLEAVABLE SOLUBILITY MODULATORS<br/>[FR] CONJUGUÉS DE MÉDICAMENT DOTÉS DE MODULATEURS DE SOLUBILITÉ PHOTOCLIVABLES
  申请人：FRIEDMAN SIMON H

  公开号：WO2018200462A1

  公开（公告）日：2018-11-01

  The present invention is directed to a composition suitable for forming an implanted light activated drug depot, methods of making the composition, and methods and systems for using the composition. The composition comprises a plurality of drug conjugates, which comprise a drug molecule and a small solubility modulating portion. The drug conjugates are insoluble upon implantation as a drug depot into a subject, and the drug is preferably soluble once cleaved from the depot. One aspect of the invention is directed to a drug conjugate having a modulating portion that modifies the solubility of the drug conjugate by employing a hydrophobic non-polar moiety. Another aspect of the invention is directed to a drug conjugate having a modulating portion that modifies the solubility of the drug by employing a charged moiety that shifts the isoelectric point of the drug conjugate to a physiological pH.

  该发明涉及一种适用于形成植入式光活化药物库的组合物，制备该组合物的方法，以及使用该组合物的方法和系统。该组合物包括多种药物共轭物，其中包括药物分子和小溶解度调节部分。这些药物共轭物在植入到受试者体内作为药物库时是不溶的，而一旦从库中解离出来，药物则最好是可溶的。该发明的一个方面涉及具有通过使用疏水非极性基团改变药物共轭物溶解度的调节部分的药物共轭物。该发明的另一个方面涉及具有通过使用带电基团改变药物溶解度的调节部分的药物共轭物，该基团将药物共轭物的等电点转移到生理pH值。