5-Amino-2,3,4-trihydroxy-6-oxohexanoic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 5-Amino-2,3,4-trihydroxy-6-oxohexanoic acid
• 化学式: C₆H₁₁NO₆
• 分子量: 193.15
• InChiKey: BBWFIUXRDWUZMZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -5.1
• 重原子数：
  13
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  141
• 氢给体数：
  5
• 氢受体数：
  7

文献信息

• Extracellular microbial lipoheteropolysaccharides and derivatives, their preparation and compositions containing them, and their uses
  申请人：Petroleum Fermentations N.V.

  公开号：EP0016546A1

  公开（公告）日：1980-10-01

  Growth of Acinetobacter Sp. ATCC31012 on various substrates and under varying conditions has been used to produce two classes of extracellular microbial protein-associated lipopolysaccnarides (the "emulsans") which, on a weight-for-weight basis, are probably the most efficient emulsifiers discovered and which possess certain characteristics that permit these unique extracellular microbial lipopolysaccharides to be widely used in cleaning oil-contaminated vessels, oil spill management, and enhanced oil recovery by chemical flooding. These classes have been named a-emulsans and β-emulsans, both of which have substantially the same polymer backbone but differ from each other in certain imoortant structural aspects. Deproteinization of emulsans by hot phenol extraction produces the lipopolysaccharide components (the "apoemulsans") of each of such emulsans. which components have been shown to be completely N-acylated and partially O-acylated heteropolysaccharides made up of a major amounts of D-galactosamine and an aminouronic acid, the O-lipoacyl portions of such apoemulsans containing varying percentages of fatty acid esters in which the fatty acids contain from about 10 to about 18 carbon atoms. Base hydrolysis under mild conditions of the emulsans and apoemulsans produces derivatives (the "ψ-emulsans" and "apo-ψ-emulsans", respectively) which are completely N-acylated and partially to completely O-deacylated. Base hydrolysis under strong conditions of any of these products produces another derivate (the "proemulsans") which is completely O-deacylated and is partially N-deacylated. Emulsans and apoemulsans, both of which biopolymers are strongly anionic, exhibit a high degree of specificity in the emulsification of hydrocarbon substrates which contain both aliphatic and cyclic components. In addition, these extracellular microbial polysaccharides as well as their O-deacylated and N-deacylated derivativesare adsorbed on and capable of flocculating aluminosilicate ion-exchangers, such as kaolin and bentonite.

  在各种基质和不同条件下生长的不动杆菌（Acinetobacter Sp.ATCC31012 在各种基质和不同条件下生长，产生了两类细胞外微生物蛋白相关脂多糖（"乳化剂"），按重量比计算，这两类脂多糖可能是目前发现的最有效的乳化剂，它们具有某些特性，使这些独特的细胞外微生物脂多糖可广泛用于清洗受油污污染的船只、溢油管理和通过化学浸泡提高石油回收率。这些类别被命名为 a 型乳聚糖和 β 型乳聚糖，两者的聚合物骨架基本相同，但在某些重要的结构方面存在差异。通过热苯酚萃取法对乳聚糖进行脱蛋白处理，可得到每种乳聚糖的脂多糖成分（"脂乳聚糖"），这些成分已被证明是完全 N-酰化和部分 O-酰化的杂多糖，由大量的 D-半乳糖胺和一种氨基尿酸组成，这种脂乳聚糖的 O-脂酰部分含有不同比例的脂肪酸酯，其中脂肪酸含有约 10 至约 18 个碳原子。在温和条件下对乳化剂和低乳化剂进行碱水解，产生的衍生物（分别为 "ψ-乳化剂 "和 "低-ψ-乳化剂"）完全N-酰化，部分至完全O-脱酰化。这些产物中的任何一种在强条件下进行碱水解，都会产生另一种衍生物（"原乳化剂"），这种衍生物完全是 O-脱乙酰基，部分是 N-脱乙酰基。Emulsans 和 apoemulsans 这两种生物聚合物都具有很强的阴离子性，在乳化含有脂肪族和环状成分的碳氢化合物底物时表现出高度的特异性。此外，这些细胞外微生物多糖及其 O-脱乙酰基和 N-脱乙酰基衍生物可吸附在高岭土和膨润土等铝硅酸盐离子交换剂上，并能使其絮凝。
• POLYSACCHARIDE COMPOSITION AND METHODS OF ISOLATION OF THE EMULSION STABILIZING CATIONIC POLYELECTROLYTIC POLYSACCHARIDE
  申请人：Kaplan David L.

  公开号：US20110206772A1

  公开（公告）日：2011-08-25

  The present invention relates to purification and use of a novel emulsion stabilizing polysaccharide. In particular, a polyelectrolyte exopolysaccharide with high molecular weight comprising a high molecular weight polymer with a tri-saccharide repeating unit is disclosed. In one aspect of the invention, methods are directed to isolating and purifying a high molecular weight exopolysaccharide (EPS) from a cell supernatant. In another aspect, methods are disclosed for isolating a lipopolysaccharide (LPS) and a high molecular weight Acinetobacter polyelectrolyte exopolysaccharide (APE) from Acinetobacter bacteria. Compositions are also directed to lipid nanoparticles comprising a therapeutic agent encapsulated by a high molecular weight polysaccharide and nanoparticles comprising a therapeutic agent bound to a cationic polysaccharide cross-linked with a polyanion.
• US4230801A
  申请人：——

  公开号：US4230801A

  公开（公告）日：1980-10-28
• US4234689A
  申请人：——

  公开号：US4234689A

  公开（公告）日：1980-11-18
• US4311830A
  申请人：——

  公开号：US4311830A

  公开（公告）日：1982-01-19