1-[2-amino-3-(1H-imidazol-5-yl)propanoyl]pyrrolidine-2-carboxamide

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 1-[2-amino-3-(1H-imidazol-5-yl)propanoyl]pyrrolidine-2-carboxamide
• 化学式: C₁₁H₁₇N₅O₂
• 分子量: 251.29
• InChiKey: BVQMQRWLLWQCLL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.2
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  118
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• Dihydroorotic acid derivatives, processes for their preparing and pharmaceutical composition containing them
  申请人：TANABE SEIYAKU CO., LTD.

  公开号：EP0168042A2

  公开（公告）日：1986-01-15

  There are disclosed 1-Methy)-4,5-dihydroorotyl-histidyl-prolinamide or a pharmaceutically acceptable acid addition salt thereof, processes for their preparation and pharmaceutical compositions containing them. The prolinamide and the parmaceutically acceptable acid addition salts thereof are useful for the treatment of central nervous system disorder.

  本发明公开了1-甲基-4,5-二氢烟酰-组氨酰-脯氨酰胺或其药学上可接受的酸加成盐、其制备工艺以及含有它们的药物组合物。 脯氨酰胺及其药学上可接受的酸加成盐可用于治疗中枢神经系统疾病。
• Novel peptides, compositions containing them and processes for their production
  申请人：TANABE SEIYAKU CO., LTD.

  公开号：EP0194443A2

  公开（公告）日：1986-09-17

  Novel peptides of the formula: wherein R is hydrogen or a lower alkyl group, or a pharmaceutically acceptable salt thereof, and processes for preparing the same and pharmaceutical compositions containing the same are disclosed. The peptides and pharmaceutically acceptable salts thereof are useful for the preparation of medicaments or compositions for the treatment or prophylaxis of central nervous system disorders.

  本发明公开了式中 R 为氢或低级烷基的新型肽或其药学上可接受的盐，以及制备这些肽和含有这些肽的药物组合物的工艺。 这些肽及其药学上可接受的盐可用于制备治疗或预防中枢神经系统疾病的药物或组合物。
• Process and composition for increasing brain dopamine release
  申请人：MASSACHUSETTS INSTITUTE OF TECHNOLOGY

  公开号：EP0373904A1

  公开（公告）日：1990-06-20

  Compositions useful in the treatment of inadequate neuronal dopamine release, as well as methods of use therefor. The compositions include drugs, such as thyrotropin-releasing hormone, which result in enhanced release of dopamine and tyrosine or a tyrosine precursor.

  用于治疗神经元多巴胺释放不足的组合物及其使用方法。这些组合物包括药物，如促甲状腺激素释放激素，它能增强多巴胺和酪氨酸或酪氨酸前体的释放。
• Cyclic prosaposin peptides and uses thereof
  申请人：CHILDREN'S MEDICAL CENTER CORPORATION

  公开号：US11191805B2

  公开（公告）日：2021-12-07

  Provided herein are cyclic prosaposin peptides and compositions and uses thereof. Exemplary uses include use in the treatment of cancer or in the treatment of inflammatory diseases or disorders.

  本文提供的是环丙沙星肽及其组合物和用途。示例用途包括用于治疗癌症或炎症性疾病或紊乱。
• NOOTROPIC
  申请人：Grünenthal GmbH

  公开号：EP0382842B1

  公开（公告）日：1993-09-22