Glycine, N-[(7-methoxy-2-oxo-2H-1-benzopyran-4-yl)acetyl]-

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Glycine, N-[(7-methoxy-2-oxo-2H-1-benzopyran-4-yl)acetyl]-
• 英文别名: 2-[[2-(7-methoxy-2-oxochromen-4-yl)acetyl]amino]acetic acid
• 化学式: C₁₄H₁₃NO₆
• mdl: MFCD04145839
• 分子量: 291.26
• InChiKey: BZWCTSYGSLDZHK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  21
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  102
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• High throughput assays for the proteotytic activities of clostridial neurotoxins
  申请人：——

  公开号：US20030077685A1

  公开（公告）日：2003-04-24

  In this application is described substrates for high-throughput assays of clostridial neurotoxin proteolytic activities. Two types of substrates are described for use in assays for the proteolytic activities of clostridial neurotoxins: (1) modified peptides or proteins that can serve as FRET substrates and (2) modified peptides or proteins that can serve as immobilized substrates. In both types a fluorescent molecules is present in the substrate, eliminating the requirement for the addition of a fluorigenic reagent. The assays described can be readily adapted for use in automated or robotic systems.

  本申请介绍了用于高通量检测梭状芽孢杆菌神经毒素蛋白水解活性的底物。本申请介绍了两种用于梭状芽孢杆菌神经毒素蛋白水解活性检测的底物：(1) 可作为 FRET 底物的修饰肽或蛋白质；(2) 可作为固定底物的修饰肽或蛋白质。在这两种类型中，底物中都含有荧光分子，因此无需添加荧光试剂。所述检测方法可随时用于自动化或机器人系统。
• HIGH-THROUGHPUT ASSAYS FOR THE PROTEOLYTIC ACTIVITIES OF CLOSTRIDIAL NEUROTOXINS
  申请人：U.S. Medical Research Institute of Infectious Diseases

  公开号：EP1419390A2

  公开（公告）日：2004-05-19
• High throughput assays for the proteolytic activities of clostridial neurotoxins
  申请人：Schmidt J. James

  公开号：US20050287622A1

  公开（公告）日：2005-12-29

  In this application is described substrates for high-throughput assays of clostridial neurotoxin proteolytic activities. Two types of substrates are described for use in assays for the proteolytic activities of clostridial neurotoxins: (1) modified peptides or proteins that can serve as FRET substrates and (2) modified peptides or proteins that can serve as immobilized substrates. In both types a fluorescent molecules is present in the substrate, eliminating the requirement for the addition of a fluorigenic reagent. The assays described can be readily adapted for use in automated or robotic systems.
• US6762280B2
  申请人：——

  公开号：US6762280B2

  公开（公告）日：2004-07-13
• US7034107B2
  申请人：——

  公开号：US7034107B2

  公开（公告）日：2006-04-25