8-acetyl-4,9-dimethyl-2H-furo-[2,3-h]chromen-2-one | 312941-11-0

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: 8-acetyl-4,9-dimethyl-2H-furo-[2,3-h]chromen-2-one
• 英文别名: 8-acetyl-4,9-dimethyl-2H-furo[2,3-h]chromen-2-one；8-acetyl-4,9-dimethylfuro[2,3-h]chromen-2-one
• CAS: 312941-11-0
• 化学式: C₁₅H₁₂O₄
• 分子量: 256.258
• InChiKey: CLXGIVMJARVUKQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  19
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  56.5
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  8-acetyl-4,9-dimethyl-2H-furo-[2,3-h]chromen-2-one 在 吡啶 、 盐酸羟胺 作用下， 以 乙醇 为溶剂， 以93%的产率得到8-acetyl-4,9-dimethyl-2H-furo[2,3-h]chromen-2-one ketoxime
  参考文献：
  名称：

  Dependence of Fluorescence Properties of Compounds from Psoralen, Angelicin, and Carbazole Series on the Character of Their Terminal Substituents

  摘要：

  Absorption, luminescence excitation and emission spectra of nine compounds from 4,8,4'-tri-methylpsoralen, 4,4'-dimethylangelicin, and 1,2,3,4-tetrahydrocarbazole series with various terminal substituents were studied in water and 2-propanol. Proceeding from the data obtained in the present and also some previous studies we have formulated the main rules concerning a general mechanism of changes in the fluorescence characteristics of DNA-specific dyes depending on their chemical structure, substrate properties, and measurement medium.

  DOI：

  10.1023/b:rujo.0000003169.96393.1d
• 作为产物：
  描述：

  8-乙酰基-7-羟基-4-甲基-2H-1-苯并吡喃-2-酮 、 一氯丙酮 在 potassium carbonate 作用下， 以 乙腈 为溶剂， 以65%的产率得到8-acetyl-4,9-dimethyl-2H-furo-[2,3-h]chromen-2-one
  参考文献：
  名称：

  Dependence of Fluorescence Properties of Compounds from Psoralen, Angelicin, and Carbazole Series on the Character of Their Terminal Substituents

  摘要：

  Absorption, luminescence excitation and emission spectra of nine compounds from 4,8,4'-tri-methylpsoralen, 4,4'-dimethylangelicin, and 1,2,3,4-tetrahydrocarbazole series with various terminal substituents were studied in water and 2-propanol. Proceeding from the data obtained in the present and also some previous studies we have formulated the main rules concerning a general mechanism of changes in the fluorescence characteristics of DNA-specific dyes depending on their chemical structure, substrate properties, and measurement medium.

  DOI：

  10.1023/b:rujo.0000003169.96393.1d

文献信息

• ——
  作者：A. Yu. Tolmachev、N. Ya. Podkhalyuzina、N. A. Kuznetsova、V. F. Traven'

  DOI：10.1023/a:1012434702051

  日期：——

  A new procedure was developed for the synthesis of 8-alkoxycarbonylangelieins by base-catalyzed cyclization of ortho-acyl(hydroxy)coumarins with haloacetic acid esters. The procedure was successfully applied to prepare a series of new 8-alkoxycarbonyl- and 8-acylangelicins.
• SYNTHESIS OF 4,9-DIMETHYL-8- (6-ARYL-2-THIOXO-1,2,3,6-TETRAHYDRO PYRIMIDIN-4-YL)-FURO[2,3-H]CHROMEN-2-ONES AS ANTIMICROBIAL AGENTS UNDER MICROWAVE IRRADIATION
  作者：P. Narsimha Reddy、G. V.Panakal Rao、M. Kanakalingeswara Rao、B. Rajitha

  DOI：10.1080/10426500490484940

  日期：2004.11.1

  Acrolyl furochromen-2-ones (3a-i) obtained in good yields on microwave irradiation of furochromen-2-one (1) with various,simple and substituted aromatic aldehydes (2a-i). 3a-g on cyclo dehydration with thiourea in domestic microwave oven furnished tetrahydro thiaxopyrimidine furochromen-2-ones 4a-i in high yields. The structures of the newly synthesized compounds were established on the basis of analytical and spectral data, IR, and H-1 NMR.
• ARYL HYDROCARBON RECEPTOR ANTAGONISTS AND METHODS OF USE
  申请人：Magenta Therapeutics Inc.

  公开号：US20210220408A1

  公开（公告）日：2021-07-22

  The disclosure relates to aryl hydrocarbon receptor antagonists as well as methods of modulating aryl hydrocarbon receptor activity and expanding hematopoietic stem cells by culturing hematopoietic stem or progenitor cells in the presence of these agents. Additionally, the disclosure provides methods of treating various pathologies, such as cancer, by administration of these aryl hydrocarbon receptor antagonists. Additionally, the disclosure provides methods of treating various pathologies in a patient by administration of expanded hematopoietic stem cells. The disclosure further provides kits containing aryl hydrocarbon receptor antagonists that can be used for the expansion of hematopoietic stem cells. The disclosure further relates to pharmaceutical compositions comprising the compounds and methods of treating or preventing a disease in which aryl hydrocarbon receptor plays a role.
• Dependence of Fluorescence Properties of Compounds from Psoralen, Angelicin, and Carbazole Series on the Character of Their Terminal Substituents
  作者：V. S. Sibirtsev、A. Yu. Tolmachev、V. V. Suslov、A. V. Garabadzhiu、V. F. Traven'

  DOI：10.1023/b:rujo.0000003169.96393.1d

  日期：2003.6

  Absorption, luminescence excitation and emission spectra of nine compounds from 4,8,4'-tri-methylpsoralen, 4,4'-dimethylangelicin, and 1,2,3,4-tetrahydrocarbazole series with various terminal substituents were studied in water and 2-propanol. Proceeding from the data obtained in the present and also some previous studies we have formulated the main rules concerning a general mechanism of changes in the fluorescence characteristics of DNA-specific dyes depending on their chemical structure, substrate properties, and measurement medium.