Proline, 3-hydroxy-4-methyl-

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Proline, 3-hydroxy-4-methyl-
• 英文别名: 3-hydroxy-4-methylpyrrolidine-2-carboxylic acid
• 化学式: C₆H₁₁NO₃
• 分子量: 145.16
• InChiKey: COHFSKKGVFGDFH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.4
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  69.6
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• Antibiotic agents
  申请人：MERCK & CO. INC.

  公开号：EP0405998A1

  公开（公告）日：1991-01-02

  New antibiotic agents produced by the cultivation of Zalerion arboricola are described. The agents are a cyclic lipopeptides with very high activity against human pathogens and of very low mammalian toxicity.

  本文介绍了通过培养 arboricola Zalerion 生产的新型抗生素制剂。这些制剂是一种环状脂肽，对人类病原体具有很高的活性，对哺乳动物的毒性很低。
• Cyclic hexapeptides having antibiotic activity
  申请人：MERCK & CO. INC.

  公开号：EP0500170A2

  公开（公告）日：1992-08-26

  Compounds of the formula and wherein R1 is hydrogen or hydroxyl; R2 is hydrogen; hydroxyl or methyl, R3 is hydrogen or hydroxyl; R4 is Cs-C23 alkyl, C5-C23 alkenyl, aryl or substituted aryl; R5 is -CH20H, -CH(CH3)OH, -CH(CH2CONH2)OH; R6 is -CH20H or -CH(CH3)OH; R is -CH20H or -CH(CH3)OH; provided that when R4 is -(CH2)8CH(CH3)CH2CH(CH3)-C2Hs, R5 is -CH20H or -CH(CH3)OH. The compounds are useful as antimicrobial agents, especially as antifungal agents.

  式中的化合物 和 其中 R1 是氢或羟基；R2 是氢；羟基或甲基；R3 是氢或羟基；R4 是 Cs-C23 烷基、C5-C23 烯基、芳基或取代芳基；R5是- 0H、-CH(CH3)OH、-CH( CONH2)OH；R6是- 0H或-CH( )OH；R是- 0H或-CH( )OH；但当R4是-(CH2)8CH( ) CH( )-C2Hs时，R5是- 0H或-CH( )OH。这些化合物可用作抗菌剂，尤其是抗真菌剂。
• USE OF INDUCTOR AGENTS GSE24.2 FOR PRODUCING PHARMACEUTICAL COMPOSITIONS FOR TREATING ILLNESSES RELATING TO CELLULAR SENESCENCE
  申请人：Consejo Superior De Investigaciones Científicas

  公开号：EP2216043A1

  公开（公告）日：2010-08-11

  This invention relates to the use of an inductor or activator compound GSE24.2 for producing a medicament or a pharmaceutical composition for treating a preferably human illness or pathological situation caused by a senescence process. Said pharmaceutical composition can be useful for a treatment for regenerating tissues, for example of epithelial tissues or haematopoietic cells, and also for the immortalisation of eucaryotic cells in order to use of same in biotechnological investigation or processes.

  本发明涉及使用诱导剂或激活剂化合物 GSE24.2 生产药物或药物组合物，用于治疗由衰老过程引起的人类疾病或病理情况。所述药物组合物可用于治疗组织再生，例如上皮组织或造血细胞的再生，也可用于核细胞的永生化，以便将其用于生物技术研究或工艺中。
• NP1 ACTIVITY REGULATING ELEMENTS WHICH CAN BE USED IN THE PRODUCTION OF DRUGS FOR THE TREATMENT OR PREVENTION OF HUMAN NEURODEGENERATIVE DISEASES, RESULTING DRUGS AND USE THEREOF
  申请人：Consejo Superior De Investigaciones Científicas

  公开号：EP2224002A1

  公开（公告）日：2010-09-01

  The invention relates to a series of compounds that can be used for the production of drugs or pharmaceutical compositions for the treatment or prevention of human neurological diseases, preferably neurodegenerative diseases, which inhibit the activity of the human NP1 protein which acts as an inducer of neurodegeneration and neural apoptosis. Said compounds include RNAi inhibitors of the gene expression of the NP1 gene and specific antibodies of the human NP1 protein, as well as peptides derived from same, which can be used in passive and active immunisation methods respectively against said diseases.

  本发明涉及一系列化合物，可用于生产治疗或预防人类神经系统疾病（最好是神经退行性疾病）的药物或药物组合物，这些化合物可抑制作为神经退行性和神经凋亡诱导剂的人类 NP1 蛋白的活性。所述化合物包括 NP1 基因表达的 RNAi 抑制剂和人类 NP1 蛋白的特异性抗体，以及由其衍生的肽，它们可分别用于针对上述疾病的被动和主动免疫方法。
• ACETYLCHOLINE RECEPTOR INHIBITORY PEPTIDES AND USES THEREOF
  申请人：Skinmed Co., Ltd.

  公开号：EP3904368A2

  公开（公告）日：2021-11-03

  The present invention relates to acetylcholine receptor inhibitory peptides and uses thereof, wherein phages with high binding affinity for acetylcholine receptors were screened using a random peptide recombinant phage, and acetylcholine receptor-binding peptides were selected through DNA of the phages. By having confirmed, using the selected peptides, the binding affinity for acetylcholine receptors and the effect of inhibiting the action of acetylcholine receptors, and having confirmed, via the modifications of the peptides, peptide sites and sequences that are vital in binding to acetylcholine receptors, the acetylcholine receptor inhibitory peptides of the present invention are expected to be used in the development of a cosmetic composition for alleviating wrinkles, a medicine for the prevention or treatment of acetylcholine receptor-associated diseases, and a health functional food for the amelioration thereof.

  本发明涉及乙酰胆碱受体抑制肽及其用途，其中使用随机肽重组噬菌体筛选出与乙酰胆碱受体结合亲和力高的噬菌体，并通过噬菌体的DNA筛选出乙酰胆碱受体结合肽。通过使用筛选出的肽，确认了与乙酰胆碱受体的结合亲和力和抑制乙酰胆碱受体作用的效果，并通过对肽的修饰，确认了与乙酰胆碱受体结合的重要肽位点和序列、本发明的乙酰胆碱受体抑制肽有望用于开发缓解皱纹的化妆品组合物、预防或治疗乙酰胆碱受体相关疾病的药物以及改善这些疾病的保健功能食品。