3-[3-(3-Hydroxybutanoyloxy)butanoyloxy]butanoic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 3-[3-(3-Hydroxybutanoyloxy)butanoyloxy]butanoic acid
• 化学式: C₁₂H₂₀O₇
• 分子量: 276.28
• InChiKey: CWLWBMWELZSMPG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  19
• 可旋转键数：
  10
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  110
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• ３−ヒドロキシ酪酸類の製造方法
  申请人：明治乳業株式会社

  公开号：JP2005065652A

  公开（公告）日：2005-03-17

  【課題】 (R)-3-ヒドロキシ酪酸、(R)-3-[(R)-3-ヒドロキシブチリルオキシ]−酪酸、及び(R)-3-[(R)-3-((R)-3-ヒドロキシブチリルオキシ)-ブチリルオキシ]−酪酸を効率よく高収量で製造する方法を提供すること。【解決手段】 クロコブタケHypoxylon truncatumを水、有機溶媒又はこれらの混合溶媒で抽出し、この抽出物から分離することを特徴とする(R)-3-ヒドロキシ酪酸、(R)-3-[(R)-3-ヒドロキシブチリルオキシ]-酪酸、(R)-3-[(R)-3-((R)-3-ヒドロキシブチリルオキシ)-ブチリルオキシ]−酪酸又はこれらの塩もしくはエステルの製造方法。【選択図】 なし

  高效高产(R)-3-羟基丁酸、(R)-3-[(R)-3-羟基丁酰氧基]-丁酸和(R)-3-[(R)-3-((R)-3-羟基丁酰氧基)-丁酰氧基]-丁酸的方法本发明提供了高效和高产率生产丁酸的方法。该方法的特征在于：用水、有机溶剂或混合溶剂萃取黑木耳 Hypoxylon truncatum，萃取液中分离出(R)-3-羟基丁酸、(R)-3-[(R)-3-羟基丁酰氧基]-丁酸、(R)-3-[(R)-3-((R)-3-[(R)-3-羟基丁酰氧基]-丁酸或其盐或酯。无。
• Oligomeric forms of 3-hydroxybutyrate
  申请人：Oulun Yliopisto

  公开号：US20170196826A1

  公开（公告）日：2017-07-13

  The present invention relates to medicaments based on oligomeric forms of 3-hydroxybutyrate, particularly 3-hydroxybutyrate methyl ester dimer (1) and trimer (2), especially for use in treating, preventing and/or inhibiting development of a disorder or condition related to oxidative stress. The present invention relates also to the use of these molecules as antioxidants, and to a method for increasing proliferation and viability of plant cells in the aid of molecules 1 and 2.
• [EN] OLIGOMERIC FORMS OF 3-HYDROXYBUTYRATE<br/>[FR] FORMES OLIGOMÉRIQUES DU 3-HYDROXYBUTYRATE
  申请人：OULUN YLIOPISTO

  公开号：WO2016012657A1

  公开（公告）日：2016-01-28

  The present invention relates to medicaments based on oligomeric forms of 3- hydroxybutyrate, particularly 3-hydroxybutyrate methyl ester dimer (1) and trimer (2), especially for use in treating, preventing and/or inhibiting development of a disorder or condition related to oxidative stress. The present invention relates also to the use of these molecules as antioxidants, and to a method for increasing proliferation and viability of plant cells in the aid of molecules 1and 2.
• [EN] KETONE ESTER AS A THERAPEUTIC TREATMENT OF COVID-19, LONG COVID, AND RELATED VIRAL INFECTIONS<br/>[FR] ESTER DE CÉTONE EN TANT QUE TRAITEMENT THÉRAPEUTIQUE D'INFECTIONS VIRALES DE TYPE COVID-19, COVID LONG, ET INFECTIONS ASSOCIÉES
  申请人：KETONEAID INC

  公开号：WO2021195477A1

  公开（公告）日：2021-09-30

  Ketone bodies can be used to treat the human body from viral infections, and will overcome the cytokine storm, which leads to acute lung injury/acute respiratory distress syndrome. Based on this discovery, methods of treating humans from a viral infection like Covid-19 are disclosed which includes a therapeutically effective amount of an exogenous ketones including, but not limited to, ketone monoester (R)-3-hydroxybutyl (R)-3- hydroxybutanoate.