7-[3-Hydroxy-2-(3-hydroxy-octyl)-5-oxo-cyclopentyl]-heptanoic acid

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 7-[3-Hydroxy-2-(3-hydroxy-octyl)-5-oxo-cyclopentyl]-heptanoic acid
• 英文别名: 7-[3-Hydroxy-2-(3-hydroxyoctyl)-5-oxocyclopentyl]heptanoic acid
• 化学式: C₂₀H₃₆O₅
• 分子量: 356.503
• InChiKey: DPOINJQWXDTOSF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  25
• 可旋转键数：
  14
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  94.8
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• BONE FRACTURE REPAIR BY TARGETING OF AGENTS THAT PROMOTE BONE HEALING
  申请人：Kopecek Jindrich

  公开号：US20180147286A1

  公开（公告）日：2018-05-31

  Aspects of the present disclosure generally relate to compounds for targeting and healing bone fractures. Some of these compounds include a negatively charged oligopeptide comprising an acidic oligopeptide, a linker, which may be hydrolyzable or may be a substrate for the protease cathepsin K, and at least one molecule that promotes bone healing. In some compounds the molecule that promotes bone healing is an anabolic compound that inhibits GSK3β, in some compounds the molecule that promotes the healing of bone fracture is a pro-inflammatory agent such as PGE1. Other embodiments include methods of treating a bone fracture comprising administering a therapeutic amount of any one of the compounds disclosed herein.
• US3984455A
  申请人：——

  公开号：US3984455A

  公开（公告）日：1976-10-05