7-Chloro-2-(1-methylpyrazol-4-yl)thieno[3,2-b]pyridine | 1033276-91-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻吩并吡啶类
• 英文名称: 7-Chloro-2-(1-methylpyrazol-4-yl)thieno[3,2-b]pyridine
• 英文别名: 7-chloro-2-(1-methylpyrazol-4-yl)thieno[3,2-b]pyridine
• CAS: 1033276-91-3
• 化学式: C₁₁H₈ClN₃S
• 分子量: 249.724
• InChiKey: LKXLOWXYFAPJPX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  59
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  7-Chloro-2-(1-methylpyrazol-4-yl)thieno[3,2-b]pyridine 、 2-氟-4-硝基苯酚 在 potassium carbonate 作用下， 以 二苯醚 为溶剂， 生成
  参考文献：
  名称：

  Discovery of a novel and potent series of thieno[3,2-b]pyridine-based inhibitors of c-Met and VEGFR2 tyrosine kinases

  摘要：

  A series of thieno[3,2-b]pyridine-based inhibitors of c-Met and VEGFR2 tyrosine kinases is described. The compounds demonstrated potency with IC50 values in the low nanomolar range in vitro while the lead compound also showed in vivo activity against various human tumor xenograft models in mice. Further exploration of this class of compounds is underway. (c) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.04.009
• 作为产物：
  描述：

  7-氯噻吩并[3,2-b]吡啶 、 alkaline earth salt of/the/ methylsulfuric acid 在 四(三苯基膦)钯 正丁基锂 、 三丁基氯化锡 作用下， 以 四氢呋喃 、 甲苯 为溶剂， 生成 7-Chloro-2-(1-methylpyrazol-4-yl)thieno[3,2-b]pyridine
  参考文献：
  名称：

  Discovery of a novel and potent series of thieno[3,2-b]pyridine-based inhibitors of c-Met and VEGFR2 tyrosine kinases

  摘要：

  A series of thieno[3,2-b]pyridine-based inhibitors of c-Met and VEGFR2 tyrosine kinases is described. The compounds demonstrated potency with IC50 values in the low nanomolar range in vitro while the lead compound also showed in vivo activity against various human tumor xenograft models in mice. Further exploration of this class of compounds is underway. (c) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.04.009

文献信息

• Discovery of a novel and potent series of thieno[3,2-b]pyridine-based inhibitors of c-Met and VEGFR2 tyrosine kinases
  作者：Stephen Claridge、Franck Raeppel、Marie-Claude Granger、Naomy Bernstein、Oscar Saavedra、Lijie Zhan、David Llewellyn、Amal Wahhab、Robert Deziel、Jubrail Rahil、Normand Beaulieu、Hannah Nguyen、Isabelle Dupont、Annie Barsalou、Carole Beaulieu、Ian Chute、Serge Gravel、Marie-France Robert、Sylvain Lefebvre、Marja Dubay、Roussen Pascal、Jeff Gillespie、Zhiyun Jin、James Wang、Jeffrey M. Besterman、A. Robert MacLeod、Arkadii Vaisburg

  DOI：10.1016/j.bmcl.2008.04.009

  日期：2008.5

  A series of thieno[3,2-b]pyridine-based inhibitors of c-Met and VEGFR2 tyrosine kinases is described. The compounds demonstrated potency with IC50 values in the low nanomolar range in vitro while the lead compound also showed in vivo activity against various human tumor xenograft models in mice. Further exploration of this class of compounds is underway. (c) 2008 Elsevier Ltd. All rights reserved.