Isoleucylthreonine

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Isoleucylthreonine
• 英文别名: 2-[(2-amino-3-methylpentanoyl)amino]-3-hydroxybutanoic acid
• 化学式: C₁₀H₂₀N₂O₄
• 分子量: 232.28
• InChiKey: DRCKHKZYDLJYFQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.3
• 重原子数：
  16
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  113
• 氢给体数：
  4
• 氢受体数：
  5

文献信息

• Method for obtaining peptide fragments by use of fluorinated organic acids
  申请人：SEIKO INSTRUMENTS INC.

  公开号：EP0885899A1

  公开（公告）日：1998-12-23

  This method obtains peptide fragments having ends of specific amino acids from a protein, which does not use an enzyme and thus is associated with minimum contamination. An organic acid represented by a general formula; CF3-(CF2) n-COOH, wherein n is an integer of 0 or larger, is allowed to act on a protein or peptide.

  这种方法可以从蛋白质中获得具有特定氨基酸末端的肽片段，无需使用酶，因此污染最小。通式为 CF3-(CF2) n-COOH（其中 n 为 0 或更大的整数）的有机酸可作用于蛋白质或肽。
• PRECISE ESTIMATION OF GLOMERULAR FILTRATION RATE FROM MULTIPLE BIOMARKERS
  申请人：THE JOHNS HOPKINS UNIVERSITY

  公开号：US20170276669A1

  公开（公告）日：2017-09-28

  The present invention relates to the field of nephrology. More specifically, the present invention provides methods and compositions useful for more precisely estimating glomerular filtration rate (GFR). In a specific embodiment, a method for calculating the estimated glomerular filtration rate (eGFR) in a patient comprises the steps of (a) measuring the level of one or more metabolites using mass spectrometry from a blood sample obtained from the patient; and (b) calculating the eGFR using an algorithm that utilizes the measured levels of the one or more metabolites.
• System, Method and Apparatus for Determining the Effect of Genetic Variants
  申请人：METABOLON, INC.

  公开号：US20180314790A1

  公开（公告）日：2018-11-01

  Methods using a combination of metabolomics and computer technology to determine sequence variants with potential negative or detrimental effects and enable the classification of a variant with an unknown or uncertain clinical significance from VUS status to benign, pathogenic or advantageous are described. For example, methods of using metabolomics to expedite personalized medicine based on genomic sequence analysis are described. Using metabolic profiles to determine (or aid in determining) the significance of genetic variants and enable the identification of diagnostic variants (those variants having a detrimental health affect) for use in personalized medicine is described. Further, using metabolic profiles to determine the presence of advantageous variants that may have a positive effect on patient health is also described.
• [EN] NOVEL USES OF A COMBINATION OF JUNIPER BERRY EXTRACT AND CHARCOAL<br/>[FR] NOUVELLES UTILISATIONS D'UNE COMBINAISON D'EXTRAIT DE BAIES DE GENIÈVRE ET DE CHARBON<br/>[RU] НОВЫЕ ПРИМЕНЕНИЯ КОМБИНАЦИИ ЭКСТРАКТА ЯГОД МОЖЖЕВЕЛЬНИКА И УГЛЯ
  申请人：OBSHCHESTVO S OGRANICHENNOY OTVETSTVENNOSTYU SPLAT GLOBAL

  公开号：WO2020027689A1

  公开（公告）日：2020-02-06

  Изобретение относится к новым применениям комбинации Экстракта ягод можжевельника и Угля в профилактике и лечении афтозного стоматита, нормализации минерального состава слюны, нормализации локального иммунного ответа в полости рта, нормализации микробиоты в полости рта, нормализации кислотно-щелочного баланса в полости рта, нормализации метаболома слюнной жидкости, а также зубной пасте, содержащей такую комбинацию.