5-amino-2-(3,3-dihydroxypropyl)-N-[2-(2-methoxyethoxy)ethyl]-4-oxooctanamide

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 5-amino-2-(3,3-dihydroxypropyl)-N-[2-(2-methoxyethoxy)ethyl]-4-oxooctanamide
• 化学式: C₁₆H₃₂N₂O₆
• 分子量: 348.43
• InChiKey: DQLNBCWFMWZDFV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.2
• 重原子数：
  24
• 可旋转键数：
  15
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  131
• 氢给体数：
  4
• 氢受体数：
  7

文献信息

• FUNCTIONALIZED SOLID POLYMER NANOPARTICLES FOR DIAGNOSTIC AND THERAPEUTIC APPLICATIONS
  申请人：Fischer Katrin Claudia

  公开号：US20100196280A1

  公开（公告）日：2010-08-05

  The present invention describes polymer nanoparticles with a cationic surface potential, in which both hydrophobic and hydrophilic pharmaceutically active substances can be encapsulated. The hydrophilic and thus water-soluble substances are encapsulated in the particle core by co-precipitation through ionic complexing with a charged polymer. Both therapeutic agents and diagnostic agents can be used as pharmaceutically active substances for encapsulation. The cationic particle surface permits stable, electrostatic surface modification with partially oppositely charged compounds, which can contain target-specific ligands for improving passive and active targeting.