N(6)-(octanoyl)lysine | 23735-96-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N(6)-(octanoyl)lysine
• 英文别名: N6-(1-oxooctyl)-L-lysine；2-amino-6-(octanoylamino)hexanoic acid
• CAS: 23735-96-8
• 化学式: C₁₄H₂₈N₂O₃
• 分子量: 272.388
• InChiKey: DUZODDYGMSCYMJ-UHFFFAOYSA-N

物化性质

• 密度：
  1.1 at 20℃
• LogP：
  -2 at 20℃ and pH6.4
• 表面张力：
  57.8mN/m at 121mg/L and 20℃
• 物理描述：
  Solid

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  19
• 可旋转键数：
  12
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  92.4
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• GEL COMPOSITION CONTAINING ACYL BASIC AMINO ACID DERIVATIVE
  申请人：AJINOMOTO CO., INC.

  公开号：EP3323868A1

  公开（公告）日：2018-05-23

  The present invention aims to provide a gel composition capable of being stably present in a gel state in a wide pH region, in which white turbidity is suppressed. A composition containing (A) a compound represented by the formula (1) : wherein each symbol is as defined in the DESCRIPTION, or a salt thereof, (B) a compound represented by the formula (2B): wherein each symbol is as defined in the DESCRIPTION, or a salt thereof, and (C) water.

  本发明旨在提供一种凝胶组合物，该组合物能够在较宽的 pH 值范围内以凝胶状态稳定存在，并能抑制白色浑浊。 该组合物含有(A)式(1)所代表的化合物： 其中各符号如说明书中所定义，或其盐、 (B) 由式(2B)表示的化合物： 其中各符号如描述中所定义，或其盐，和 (C) 水。
• METHOD FOR PRODUCING N EPSILON -ACYL-L-LYSINE
  申请人：Ajinomoto Co., Inc.

  公开号：EP3375883A1

  公开（公告）日：2018-09-19

  The present invention provides a method for producing Nε-dodecanoyl-L-lysine using an enzyme having properties suitable for the industrial production of Nε-dodecanoyl-L-lysine. More specifically, the present invention provides a method for producing Nε-acyl-L-lysine including reacting a carboxylic acid or a salt thereof and L-lysine or a salt thereof in the presence of any of the following (A) to (C) proteins to produce Nε-acyl-L-lysine: (A) a protein comprising an amino acid sequence of SEQ ID NO: 1; (B) a protein comprising an amino acid sequence in which one or several amino acid residues are inserted, added, deleted, or substituted in the amino acid sequence of SEQ ID NO: 1 and having Nε-acyl-L-lysine-specific aminoacylase activity; and (C) a protein comprising an amino acid sequence having 90% or higher homology with the amino acid sequence of SEQ ID NO: 1 and having Nε-acyl-L-lysine-specific aminoacylase activity.

  本发明提供了一种利用一种酶生产 Nε-十二碳酰基-L-赖氨酸的方法，该酶具有适于工业生产 Nε-十二碳酰基-L-赖氨酸的特性。更具体地说，本发明提供了一种生产 Nε-酰基-L-赖氨酸的方法，包括在下列(A)至(C)任一蛋白质存在下，使羧酸或其盐和 L-赖氨酸或其盐反应，以生产 Nε-酰基-L-赖氨酸： (A) 包含 SEQ ID NO: 1 氨基酸序列的蛋白质； (B) 包含在 SEQ ID NO: 1 的氨基酸序列中插入、添加、删除或替换了一个或多个氨基酸残基的氨基酸序列并具有 Nε-酰基-L-赖氨酸特异性氨基酰化酶活性的蛋白质；以及 (C) 包含与 SEQ ID NO: 1 的氨基酸序列具有 90% 或更高同源性且具有 Nε-酰基-L-赖氨酸特异性氨 基化酶活性的氨基酸序列的蛋白质。
• Method for producing Nε-acyl-L-lysine
  申请人：AJINOMOTO CO., INC.

  公开号：US10266857B2

  公开（公告）日：2019-04-23

  The present invention provides a method for producing Nε-dodecanoyl-L-lysine using an enzyme having properties suitable for the industrial production of Nε-dodecanoyl-L-lysine. More specifically, the present invention provides a method for producing Nε-acyl-L-lysine including reacting a carboxylic acid or a salt thereof and L-lysine or a salt thereof in the presence of a protein having an amino acid sequence of SEQ ID NO: 1; a protein having an amino acid sequence in which one or several amino acid residues are inserted, added, deleted, or substituted in the amino acid sequence of SEQ ID NO: 1 and having Nε-acyl-L-lysine-specific aminoacylase activity; and a protein which has 90% or higher homology with the amino acid sequence of SEQ ID NO: 1 and having Nε-acyl-L-lysine-specific aminoacylase activity.

  本发明提供了一种利用一种酶生产 Nε-十二碳酰基-L-赖氨酸的方法，该酶具有适于工业生产 Nε-十二碳酰基-L-赖氨酸的特性。更具体地说，本发明提供了一种生产 Nε-酰基-L-赖氨酸的方法，包括在具有 SEQ ID NO：1 的氨基酸序列的蛋白质；具有在 SEQ ID NO: 1 的氨基酸序列中插入、添加、删除或取代一个或多个氨基酸残基的氨基酸序列并具有 Nε-酰基-L-赖氨酸特异性氨基酰化酶活性的蛋白质；以及与 SEQ ID NO: 1 的氨基酸序列具有 90% 或更高同源性并具有 Nε-酰基-L-赖氨酸特异性氨基酰化酶活性的蛋白质。
• Composition for cosmetics and cosmetics comprising same
  申请人：AJINOMOTO CO., INC

  公开号：US10786437B2

  公开（公告）日：2020-09-29

  Compositions for cosmetics containing (A) one or more kinds of N-mono long-chain acyl basic amino acids, and (B) one or more kinds of N-mono middle-chain acyl basic amino acids, and compositions for cosmetics further containing (C) an inorganic powder, provide cosmetics that give, on application, a comfortable silky feeling and, to the skin after application, a natural translucency, good luminous finish and a uniform feeling of the skin surface, and have adhesiveness to the skin and high covering power.

  含有(A)一种或多种 N-单长链酰基碱性氨基酸和(B)一种或多种 N-单中链酰基碱性氨基酸的化妆品组合物，以及进一步含有(C)无机粉末的化妆品组合物，可提供涂抹时具有舒适的丝滑感，涂抹后皮肤具有自然的半透明性、良好的光洁度和皮肤表面的均匀感，并且对皮肤具有粘附性和高遮盖力的化妆品。