4-Hydroxy-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 4-Hydroxy-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate
• 英文别名: 4-hydroxy-2,3,4,5-tetrahydropyridine-2,6-dicarboxylic acid
• 化学式: C₇H₉NO₅
• 分子量: 187.15
• InChiKey: DVTPRYHENFBCII-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.2
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  107
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• AMINO ACID PRODUCTION
  申请人：Evonik Operations GmbH

  公开号：EP3613850A1

  公开（公告）日：2020-02-26

  The present invention relates to a microbial cell for producing at least one L-amino acid from at least one C1-C4 alkane, wherein the cell comprises: (v) an increased expression relative to the wild type cell of Enzyme E1 capable of converting the alkane to a corresponding 1-alkanol; (vi) an increased expression relative to the wild type cell of Enzyme E2 capable of converting the 1-alkanol of (i) to a corresponding aldehyde; and either (vii) (A) - an increased expression relative to the wild type cell of Enzyme E3 capable of converting the aldehyde of (ii) to a corresponding alkanoic acid; and - a wild-type level expression of Enzyme E4 or an increased expression relative to the wild type cell of Enzyme E4 capable of converting the alkanoic acid of (iii) to a corresponding fatty acyl thioester; or (B) - an increased expression relative to the wild type cell of Enzyme E5 capable of converting the aldehyde of (ii) to a corresponding fatty acyl thioester; and (viii) an increased expression relative to the wild type cell of Enzyme E6 capable of converting the fatty acyl thioester of (iii) to a corresponding amino acid

  本发明涉及一种用至少一种 C1-C4 烷烃生产至少一种 L-氨基酸的微生物细胞，其中该细胞包括 (v) 相对于野生型细胞，能将烷烃转化为相应的 1-烷醇的酶 E1 的表达量增加； (vi) 相对于野生型细胞，能够将(i)的 1-烷醇转化为相应的醛的酶 E2 的表达量增加；以及 (vii) 相对于野生型细胞，能够将(i)的 1-烷醇转化为相应的醛的酶 E3 的表达量增加。 (vii) (A) - 与野生型细胞相比，能够将(ii)的醛转化为相应的烷酸的酶 E3 的表达量增加；以及 - 酶 E4 的野生型水平表达或相对于野生型细胞酶 E4 的表达增加，能将(iii) 的烷酸转化为相应的脂肪酰硫酯；或 (B) - 相对于野生型细胞，能将(ii)的醛转化为相应的脂肪酰硫酯的酶 E5 的表达量增加； 和 (viii) 相对于野生型细胞，能将(iii)的脂肪酰硫酯转化为相应氨基酸的酶 E6 的表达量增加
• Methods for screening bacteria, archaea, algae, and yeast using CRISPR nucleic acids
  申请人：North Carolina State University

  公开号：US10136649B2

  公开（公告）日：2018-11-27

  This invention relates to the use of CRISPR nucleic acids to screen for essential and non-essential genes and expendable genomic islands in bacteria, archaea, algae and/or yeast, to kill bacteria, archaea, algae and/or yeast, to identify the phenotype of a gene or genes, and/or to screen for reduced genome size and/or a gene deletion in bacteria, archaea, algae and/or yeast.

  本发明涉及使用 CRISPR 核酸筛选细菌、古菌、藻类和/或酵母中的必需和非必需基因以及消耗性基因组岛，杀死细菌、古菌、藻类和/或酵母，鉴定一个或多个基因的表型，和/或筛选细菌、古菌、藻类和/或酵母中基因组大小减小和/或基因缺失。
• Streptomyces endophyte compositions and methods for improved agronomic traits in plants
  申请人：INDIGO AG, INC.

  公开号：US10750711B2

  公开（公告）日：2020-08-25

  This invention relates to methods and compositions for providing a benefit to a plant by associating the plant with a beneficial endophyte of the genus Streptomyces, including benefits to a plant derived from a seed or other plant element treated with said endophyte. For example, this invention provides purified endophytes, synthetic combinations comprising endophytes, and methods of making and using the same. In particular, this invention relates to compositions and methods of improving soybean and maize plants.

  本发明涉及通过将植物与有益的链霉菌属内生菌结合而为植物提供益处的方法和组合物，包括为经所述内生菌处理的种子或其他植物元素衍生的植物提供益处。例如，本发明提供了纯化的内生菌、包含内生菌的合成组合物以及制造和使用方法。特别是，本发明涉及改良大豆和玉米植物的组合物和方法。
• BACTERIAL CONJUGATIVE SYSTEM AND THERAPEUTIC USES THEREOF
  申请人：Société de commercialisation des produits de la recherche appliquée SOCPRA Sciences Santé et Humaines s.e.c.

  公开号：EP3821021A1

  公开（公告）日：2021-05-19
• METHODS FOR SCREENING BACTERIA, ARCHAEA, ALGAE, AND YEAST USING CRISPR NUCLEIC ACIDS
  申请人：North Carolina State University

  公开号：US20160345578A1

  公开（公告）日：2016-12-01

  This invention relates to the use of CRISPR nucleic acids to screen for essential and non-essential genes and expendable genomic islands in bacteria, archaea, algae and/or yeast, to kill bacteria, archaea, algae and/or yeast, to identify the phenotype of a gene or genes, and/or to screen for reduced genome size and/or a gene deletion in bacteria, archaea, algae and/or yeast.