N-(2-phenylethyl)dec-2-enamide

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: N-(2-phenylethyl)dec-2-enamide
• 化学式: C₁₈H₂₇NO
• 分子量: 273.4
• InChiKey: FCIPJOIXUBQWOX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  20
• 可旋转键数：
  10
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• TRANS-2-DECENOIC ACID DERIVATIVE AND PHARMACEUTICAL AGENT CONTAINING THE SAME
  申请人：Iinuma Munekazu

  公开号：US20130225837A1

  公开（公告）日：2013-08-29

  An object of the present invention is to provide a novel trans-2-decenoic acid derivative or a pharmaceutically acceptable salt thereof and to provide a pharmaceutical agent which contains said compound as an active ingredient and has a highly safe neurotrophic factor-like activity or an alleviating action for side effect induced by administration of anti-cancer agents. The trans-2-decenoic acid derivative or a pharmaceutically acceptable salt thereof which is the compound of the present invention is specifically represented by the formula (1): (In the formula, Y is —O—, —NR— or —S—, R is hydrogen atom, alkyl group, dialkylaminoalkyl group or the like and W is a substituent such as dialkylaminoalkyl group) and has a quite high usefulness as a pharmaceutical agent such as a preventive or therapeutic agent for dementia, Alzheimer's disease, Parkinson's disease, depression, etc., a treating or repairing agent for spinal cord injury.

  本发明的目的是提供一种新的反式-2-癸烯酸衍生物或其药用盐，并提供一种包含该化合物作为活性成分并具有高度安全的神经营养因子样活性或对抗癌药物引起的副作用的缓解作用的药物制剂。本发明的反式-2-癸烯酸衍生物或其药用盐具体由化学式(1)表示：(在该式中，Y为—O—、—NR—或—S—，R为氢原子、烷基、二烷基氨基烷基或类似物，W为二烷基氨基烷基等取代基)，作为一种药用制剂，具有预防或治疗痴呆症、阿尔茨海默病、帕金森病、抑郁症等的药物，以及治疗或修复脊髓损伤的药物，具有非常高的实用性。
• ANALGESIC
  申请人：Nippon Zoki Pharmaceutical Co., Ltd.

  公开号：EP2842553A1

  公开（公告）日：2015-03-04

  An object of the present invention is to provide an analgesic effective in a prophylactic or a therapy for various pain diseases. The present invention is to provide an analgesic containing at least one member selected from a trans-2-decenoic acid derivative represented by the formula (1) and a pharmaceutically acceptable salt thereof as an active ingredient: (In the formula, Y is -O-, -NR- or -S-, R is hydrogen atom, alkyl group, dialkylaminoalkyl group or the like and W is a substituent such as dialkylaminoalkyl group). The analgesic of the present invention containing the compound as an active ingredient is highly useful as a prophylactic or therapeutic agent for various pain diseases such as the pain caused by osteoarthritis (e.g., knee osteoarthritis and hip osteoarthritis).

  本发明的目的是提供一种有效预防或治疗各种疼痛疾病的镇痛剂。本发明的目的是提供一种镇痛剂，其活性成分至少含有一种选自式（1）所代表的反式-2-癸烯酸衍生物及其药学上可接受的盐： (式中，Y为-O-、-NR-或-S-，R为氢原子、烷基、二烷基氨基烷基或类似物，W为取代基，如二烷基氨基烷基）。含有本发明化合物作为活性成分的本发明镇痛剂作为各种疼痛疾病（如骨关节炎（如膝关节骨关节炎和髋关节骨关节炎）引起的疼痛）的预防或治疗药物非常有用。
• TRANS-2-DECENOIC ACID DERIVATIVE AND MEDICAMENT CONTAINING SAME
  申请人：Nagoya Industrial Science Research Institute

  公开号：EP2636666B1

  公开（公告）日：2018-01-10
• US8987486B2
  申请人：——

  公开号：US8987486B2

  公开（公告）日：2015-03-24