6-(1-hydroxyethyl)-7-oxo-3-(1-oxothiolan-3-yl)sulfanyl-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 6-(1-hydroxyethyl)-7-oxo-3-(1-oxothiolan-3-yl)sulfanyl-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
• 化学式: C₁₂H₁₅NO₅S₃
• 分子量: 349.5
• InChiKey: FLSUCZWOEMTFAQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  165
• 氢给体数：
  2
• 氢受体数：
  8

文献信息

• Combinations of beta-lactam compounds and probenecid and uses thereof
  申请人：Iterum Therapeutics International Limited

  公开号：US11478428B2

  公开（公告）日：2022-10-25

  The present disclosure relates to bilayer tablets comprising a second layer comprising a β-lactam compound or a pharmaceutically acceptable salt thereof; and a first layer comprising probenecid or a pharmaceutically acceptable salt thereof. The present disclosure also relates to methods of treating or preventing a disease using the bilayer tablets.

  本公开涉及双层片剂，其第二层包括β-内酰胺化合物或其药学上可接受的盐；第一层包括丙磺舒或其药学上可接受的盐。本公开还涉及使用双层片剂治疗或预防疾病的方法。
• COMBINATIONS OF BETA-LACTAM COMPOUNDS AND PROBENECID AND USES THEREOF
  申请人：Iterum Therapeutics International Limited

  公开号：US20200253878A1

  公开（公告）日：2020-08-13

  The present disclosure relates to bilayer tablets comprising a second layer comprising a β-lactam compound or a pharmaceutically acceptable salt thereof; and a first layer comprising probenecid or a pharmaceutically acceptable salt thereof. The present disclosure also relates to methods of treating or preventing a disease using the bilayer tablets.
• COMBINATIONS OF BETA-LACTAM COMPOUNDS, PROBENECID, AND VALPROIC ACID AND USES THEREOF
  申请人：Iterum Therapeutics International Limited

  公开号：US20210283112A1

  公开（公告）日：2021-09-16

  The present disclosure relates to combinations of valproic acid or a pharmaceutically acceptable salt thereof, a β-lactam compound or a pharmaceutically acceptable salt thereof, and probenecid or a pharmaceutically acceptable salt thereof. The present disclosure also relates to methods of treating or preventing a disease using the combinations.