[[5-(4-Amino-2-oxo-pyrimidin-1-yl)-3-hydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl]oxyphosphonic acid

• 分子结构分类: 有机化合物 - 有机氧化合物 - 有机含氧阴离子化合物
• 英文名称: [[5-(4-Amino-2-oxo-pyrimidin-1-yl)-3-hydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl]oxyphosphonic acid
• 英文别名: [5-(4-amino-2-oxopyrimidin-1-yl)-3-hydroxyoxolan-2-yl]methyl phosphono hydrogen phosphate
• 化学式: C₉H₁₅N₃O₁₀P₂
• 分子量: 387.18
• InChiKey: FTDHDKPUHBLBTL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -4.5
• 重原子数：
  24
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  201
• 氢给体数：
  5
• 氢受体数：
  10

文献信息

• Probe for mass spectrometry of liquid sample
  申请人：——

  公开号：US20040142378A1

  公开（公告）日：2004-07-22

  Disclosed is a probe for mass spectrometry of liquid samples, which may effectively ionize the sample without adding a protic solvent to the mobile phase in the ionization method in mass spectrometry of liquid samples. The probe according to the present invention has a structure represented by the Formula [I]: R 2 -A-R  [I] (wherein R 1 represents an ionic functional group which becomes an ion in a solvent, R 2 represents a structure which can bind to other substance, and A represents an arbitrary spacer moiety).

  揭示了一种用于液体样品质谱的探针，可以在液体样品的质谱离子化方法中有效离子化样品，而无需向移动相中添加质子溶剂。根据本发明的探针具有以下式所表示的结构： R2-A-R [I] （其中R1代表在溶剂中成为离子的离子功能团，R2代表可以结合到其他物质的结构，A代表任意的间隔基团）。
• REAGENTS AND METHODS FOR REPLICATION, TRANSCRIPTION, AND TRANSLATION IN SEMI-SYNTHETIC ORGANISMS
  申请人：The Scripps Research Institute

  公开号：US20200392550A1

  公开（公告）日：2020-12-17

  Disclosed herein are compositions, methods, cells, engineered microorganisms, and kits for increasing the production of proteins or polypeptides comprising one or more unnatural amino acids. Further provided are compositions, cells, engineered microorganisms, and kits for increasing the retention of unnatural nucleic acids encoding the unnatural amino acids in an engineered cell, or semi-synthetic organism.

  本文揭示了一种用于增加含有一个或多个非天然氨基酸的蛋白质或多肽的生产的组合物、方法、细胞、工程微生物和试剂盒。此外，还提供了一种用于增加编码非天然氨基酸的非天然核酸在工程细胞或半合成生物体中的保留的组合物、细胞、工程微生物和试剂盒。
• INORGANIC-ORGANIC HYBRID COMPOUNDS INCLUDING ORGANIC PLATINUM-CONTAINING ANIONS, FOR USE IN MEDICINE
  申请人：Karlsruher Institut fur Technologie

  公开号：US20210292353A1

  公开（公告）日：2021-09-23

  The present invention relates to inorganic-organic hybrid compounds for use in medicine or for use as medication, consisting of an inorganic metal cation and an organic platinum-containing cytostatic anion, in particular also a cisplatin derivative.

  本发明涉及用于医学或作为药物使用的无机-有机杂化化合物，包括无机金属阳离子和含有铂的细胞静止阴离子，特别是顺铂衍生物。
• Sheet or tubular structure consisting of elastic biocompatible material and its use
  申请人：Charité - Universitätsmedizin Berlin

  公开号：EP2067494A1

  公开（公告）日：2009-06-10

  The present invention relates to a sheet or tubular structure consisting of biocompatible material, which is elastic and comprises at least one biologically active substance in at least one region and to a sheet or tubular structure, which comprises at least one biologically active substance release-modifying agent in at least one region as well as an implant covered at least partially by the sheet or tubular structure of the invention. The present invention further provides a method and an apparatus for producing, and preferably customizing and/or optimizing, the sheet or tubular structure of the invention. The sheet or tubular structure of the invention can be customized/optimized before implantation in the operating room.

  本发明涉及一种由生物相容性材料构成的片状或管状结构，该结构具有弹性，并在至少一个区域中包含至少一种生物活性物质；本发明还涉及一种片状或管状结构，该结构在至少一个区域中包含至少一种生物活性物质释放调节剂，以及至少部分由本发明的片状或管状结构覆盖的植入物。本发明进一步提供了一种生产本发明片状或管状结构的方法和设备，最好是定制和/或优化本发明片状或管状结构的方法和设备。本发明的片状或管状结构可在手术室植入前进行定制/优化。
• Methods using pores
  申请人：ISIS INNOVATION LIMITED

  公开号：EP2272981A1

  公开（公告）日：2011-01-12

  The invention relates to a method of identifying an individual nucleotide, comprising (a) contacting the nucleotide with a transmembrane protein pore so that the nucleotide interacts with the pore and (b) measuring the current passing through the pore during the interaction and thereby determining the identity of the nucleotide. The invention also relates to a method of sequencing nucleic acid sequences and kits related thereto.

  本发明涉及一种识别单个核苷酸的方法，包括：(a)将核苷酸与跨膜蛋白孔接触，使核苷酸与孔相互作用；(b)测量相互作用期间通过孔的电流，从而确定核苷酸的身份。本发明还涉及一种核酸序列测序方法及相关试剂盒。