2-(Butylamido)-4-hydroxybutanoic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-(Butylamido)-4-hydroxybutanoic acid
• 英文别名: 2-(butanoylamino)-4-hydroxybutanoic acid
• 化学式: C₈H₁₅NO₄
• 分子量: 189.21
• InChiKey: FWULQXYJOANGSS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  13
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  86.6
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• METHODS FOR ELIMINATING THE FORMATION OF BIOFILM
  申请人：Novozymes Biotech, Inc.

  公开号：US20040109852A1

  公开（公告）日：2004-06-10

  The present invention relates to methods for preventing or removing biofilm on a surface, comprising contacting the surface with an effective amount of a composition comprising one or more acylases and a carrier to degrade a lactone produced by one or more microorganisms, wherein the degradation of the lactone prevents or removes the biofilm.
• US6777223B2
  申请人：——

  公开号：US6777223B2

  公开（公告）日：2004-08-17
• [EN] METHODS FOR ELIMINATING THE FORMATION OF BIOFILM<br/>[FR] PROCEDES DESTINES A EMPECHER L'APPARITION D'UN FILM BIOLOGIQUE
  申请人：NOVOZYMES BIOTECH INC

  公开号：WO2001098214A1

  公开（公告）日：2001-12-27

  The present invention relates to methods for preventing or removing biofilm on a surface, comprising contacting the surface with an effective amount of a composition comprising one or more acylases and a carrier to degrade a lactone produced by one or more microorganisms, wherein the degradation of the lactone prevents or removes the biofilm.
• [EN] METHOD FOR TREATMENT AND PREVENTION OF ACUTE AND CHRONIC PSEUDOMONAS AERUGINOSA AIRWAY INFECTIONS WITH INHALABLE MACROLIDES<br/>[FR] PROCEDE DE TRAITEMENT ET DE PREVENTION DES INFECTIONS AIGUES ET CHRONIQUES DES VOIES AERIENNES PAR PSEUDOMONAS AERUGINOSA AU MOYEN DE MACROLIDES POUVANT ETRE INHALES
  申请人：ANBICS PATENTS LICENCES AG

  公开号：WO2004075874A1

  公开（公告）日：2004-09-10

  Macrolides, in particular azalides such as azithromycin, are suited for the treatment or prevention of acute or chronic P. aeruginosa infections of the airways by inhala­tion. The mechanism of action is the inhibition of the quo­rum sensing of P. aeruginosa, in particular the impediment of the las and rhl quorum sensing systems synthesis and the impediment of the synthesis of the autoinducers N-[3-oxodo­1o decanoyl]-L-homoserine lactone and N-butyrylhomoserine lac­tone. This allows for inhalation treatments of P. aerugi-nosa infections at non-inhibiting concentrations of the macrolide.