angiostatin | 3262-58-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: angiostatin
• 英文别名: Aspergillomarasmin B；Lycomarsaminsaeure；2-[[2-carboxy-2-(carboxymethylamino)ethyl]amino]butanedioic acid
• CAS: 3262-58-6
• 化学式: C₉H₁₄N₂O₈
• 分子量: 278.219
• InChiKey: FZCSTZYAHCUGEM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -6.8
• 重原子数：
  19
• 可旋转键数：
  10
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  173
• 氢给体数：
  6
• 氢受体数：
  10

文献信息

• [EN] PROCESS FOR THE PREPARATION OF 2-[2-(2-AMINO-2-CARBOXY-ETHYLAMINO)-2-CARBOXY-ETHYLAMINO]-SUCCINIC ACID (AM-A) AND ANALOGS AND DERIVATIVES THEREOF<br/>[FR] PROCÉDÉ POUR LA PRÉPARATION D'ACIDE 2-[2-(2-AMINO-2-CARBOXY-ÉTHYLAMINO)-2-CARBOXY-ÉTHYLAMINO]-SUCCINIQUE (AM-A) ET DES ANALOGUES ET DÉRIVÉS DE CELUI-CI
  申请人：UNIV MCMASTER

  公开号：WO2017070794A1

  公开（公告）日：2017-05-04

  The present application relates to processes for the preparation of the aspergillomarasmine A (AM-A) compound and analogs and derivatives thereof. The features of this process involves the use of a cyclic activated serine synthon in the construction of the poly-amino acid backbone. Also included are certain novel analogs of AM-A along with compositions comprising these compounds and uses thereof.