Pam2CSK4 | 574741-81-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Pam2CSK4
• 英文别名: (2S)-6-amino-2-[[(2S)-6-amino-2-[[(2S)-6-amino-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2R)-2-amino-3-[2,3-di(hexadecanoyloxy)propylsulfanyl]propanoyl]amino]-3-hydroxypropanoyl]amino]hexanoyl]amino]hexanoyl]amino]hexanoyl]amino]hexanoic acid
• CAS: 574741-81-4
• 化学式: C₆₅H₁₂₆N₁₀O₁₂S
• 分子量: 1271.8
• InChiKey: LJUIOEFZFQRWJG-KKIBDXJDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.5
• 重原子数：
  88
• 可旋转键数：
  65
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  411
• 氢给体数：
  12
• 氢受体数：
  18

文献信息

• [EN] IMMUNOCONJUGATE SYNTHESIS METHOD<br/>[FR] PROCÉDÉ DE SYNTHÈSE D'IMMUNOCONJUGUÉ
  申请人：BOLT BIOTHERAPEUTICS INC

  公开号：WO2018191746A1

  公开（公告）日：2018-10-18

  A method for producing an immunoconjugate, the method comprising combining one or more compounds of Formula I and an antibody of Formula II, wherein Formula II is an antibody with one or more lysine residues, in an aqueous solution buffered at a pH of about 7.5 to about 9 until at least 33 mol% of the one or more compounds of Formula I is conjugated to the antibody of Formula II to provide the immunoconjugate of Formula III, wherein Adj is an adjuvant, Z is –CH2–, –C(O)NH–, –C(O)O–, or –C(O)–, L is a linker, E is an ester, and r is the average number of adjuvants attached to the antibody and is a positive number up to about 8, in a first buffered aqueous solution.

  一种制备免疫结合物的方法，所述方法包括将一种或多种I式化合物与II式抗体结合，其中II式抗体具有一种或多种赖氨酸残基，在pH约为7.5至9的缓冲水溶液中混合，直至至少33摩尔％的一种或多种I式化合物与II式抗体结合，以提供III式免疫结合物，其中Adj是一种佐剂，Z是-CH2-，-C(O)NH-，-C(O)O-或-C(O)-，L是一个连接物，E是一个酯，r是附着到抗体上的佐剂的平均数量，是一个正数，最多约为8，在第一个缓冲水溶液中。
• Molecular Imaging of Cancer Cells In Vivo
  申请人：Morse David L.

  公开号：US20140161725A1

  公开（公告）日：2014-06-12

  Cellular targets on cancer cells have been identified that can be used with targeted molecular imaging to detect the cancer cells in vivo. Non-invasive methods for detecting cancer cells, such as metastasized cancer cells, are therefore provided. Also provided are compositions and kits for use in the disclosed methods.

  已经确定了可用于与靶向分子成像结合以在体内检测癌细胞的癌细胞细胞靶点。因此提供了用于检测癌细胞的非侵入性方法，例如转移性癌细胞。还提供了用于所述方法的组合物和试剂盒。
• Molecular imaging of cancer cells in vivo
  申请人：Morse David L.

  公开号：US10406248B2

  公开（公告）日：2019-09-10

  Cellular targets on cancer cells have been identified that can be used with targeted molecular imaging to detect the cancer cells in vivo. Non-invasive methods for detecting cancer cells, such as metastasized cancer cells, are therefore provided. Also provided are compositions and kits for use in the disclosed methods.

  癌细胞上的细胞靶点已被确定，可与靶向分子成像一起用于检测体内的癌细胞。因此，本文提供了检测癌细胞（如转移癌细胞）的非侵入性方法。此外，还提供了用于所公开方法的组合物和试剂盒。
• Antibody adjuvant conjugates
  申请人：The Board of Trustees of the Leland Stanford Junior University

  公开号：US10675358B2

  公开（公告）日：2020-06-09

  The invention provides an immunoconjugate comprising an antibody construct which includes an antigen binding domain and an Fc domain, an adjuvant moiety, and a linker, wherein each adjuvant moiety is covalently bonded to the antibody via the linker. Methods for treating cancer with the immunoconjugates of the invention are also described.

  本发明提供了一种免疫结合剂，它包括一种抗体构建体，该抗体构建体包括一个抗原结合结构域和一个Fc结构域、一个佐剂分子和一个连接体，其中每个佐剂分子通过连接体与抗体共价结合。此外，还介绍了用本发明的免疫共轭物治疗癌症的方法。
• ANTIBODY ADJUVANT CONJUGATES
  申请人：The Board of Trustees of the Leland Stanford Junior University

  公开号：EP3484518A1

  公开（公告）日：2019-05-22