Asparagylproline

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Asparagylproline
• 英文别名: 1-(2,4-diamino-4-oxobutanoyl)pyrrolidine-2-carboxylic acid
• 化学式: C₉H₁₅N₃O₄
• 分子量: 229.23
• InChiKey: GADKFYNESXNRLC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -4.2
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  127
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• Novel synthetic, immunologically active peptides useful for the preparation of antimalarial vaccines
  申请人：ENIRICERCHE S.p.A.

  公开号：EP0345867A1

  公开（公告）日：1989-12-13

  Synthetic peptides constituted by at least two repeating, consecutive units of asparaginyl-proline (Asn-­Pro)n sequence, are novel. Said peptides are power ful immunogens, capable of inducing in laboratory animals the formation of a high concentration of antibodies capable of reacting both with the (Asn-Pro)n peptides, and with the immunodominant epitope of the circumsporozoite protein of Plasmodium falciparum. Said peptides, which can be obtained in a pure form by chemical synthesis are particularly useful for preparing antimalarial vaccines, and diagnostic kits for the determination of malaria on man.

  由至少两个天冬酰胺基-脯氨酸（Asn-Pro）n 序列的连续重复单元构成的合成肽是一种新型肽。 这些肽是强效免疫原，能够在实验动物体内诱导形成高浓度的抗体，这些抗体既能与（Asn-Pro）n 肽反应，也能与恶性疟原虫周孢子虫蛋白的免疫优势表位反应。 这些肽可以通过化学合成获得纯品，特别适用于制备抗疟疫苗和用于确定人类疟疾的诊断试剂盒。
• Nutrient compositions containing peptides
  申请人：CLINTEC NUTRITION COMPANY

  公开号：EP0457314A1

  公开（公告）日：1991-11-21

  Nutrient compositions comprise an aqueous solution of at least one dipeptide with an N-terminal amino acid selected from glutamine, aspargine, tyrosine, tryptophan, and aspargine. The C-terminal amino acid is alanine, glycine, tryptophan, arginine, proline or serine. The nutritional compositions contain from about 0.1 to 25.0 percent by weight of oligopeptides, preferably about 0.5 to 5.0 percent by weight.

  营养组合物包含至少一种二肽的水溶液，其 N 端氨基酸选自谷氨酰胺、天门冬氨酸、酪氨酸、色氨酸和天门冬氨酸。 C 端氨基酸为丙氨酸、甘氨酸、色氨酸、精氨酸、脯氨酸或丝氨酸。营养组合物含有约 0.1%至 25.0%（按重量计）的低聚肽，最好是约 0.5%至 5.0%（按重量计）。
• US5116946A
  申请人：——

  公开号：US5116946A

  公开（公告）日：1992-05-26