o-(3-Carboxypropanoyl)homoserine

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: o-(3-Carboxypropanoyl)homoserine
• 英文别名: 2-amino-4-(3-carboxypropanoyloxy)butanoic acid
• 化学式: C₈H₁₃NO₆
• 分子量: 219.19
• InChiKey: GNISQJGXJIDKDJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.7
• 重原子数：
  15
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  127
• 氢给体数：
  3
• 氢受体数：
  7

文献信息

• Method for Producing Bio-Based Homoserine Lactone and Bio-Based Organic Acid from O-Acyl Homoserine Produced by Microorganisms
  申请人：CJ Cheiljedang Corporation

  公开号：US20140296466A1

  公开（公告）日：2014-10-02

  The present invention relates to a method of producing bio-based homoserine lactone and bio-based organic acid through hydrolysis of O-acyl homoserine produced by a microorganism in the presence of an acid catalyst. According to the present invention, O-acyl homoserine produced by a microorganism is used as a raw material for producing 1,4-butanediol, gamma-butyrolactone, tetrahydrofuran and the like, which are industrially highly useful. The O-acyl homoserine produced by a microorganism can substitute conventional petrochemical products, can solve environmental concerns, including the emission of pollutants and the exhaustion of natural resources, and can be continuously renewable so as not to exhaust natural resources.

  本发明涉及一种通过在酸催化剂存在下水解微生物产生的O-酰基同型半胱氨酸，生产基于生物的同型半胱氨酸内酯和基于生物的有机酸的方法。根据本发明，利用微生物产生的O-酰基同型半胱氨酸作为原料，生产1,4-丁二醇、γ-丁内酯、四氢呋喃等工业上非常有用的产品。微生物产生的O-酰基同型半胱氨酸可以替代传统的石化产品，可以解决环境问题，包括污染物排放和自然资源枯竭，并且可以持续可再生，不会耗尽自然资源。
• DIMERIC IAP INHIBITORS
  申请人：STRAUB Christopher Sean

  公开号：US20110206690A1

  公开（公告）日：2011-08-25

  The present invention provides compounds of formula M-L-M′ (where M and M′ are each independently a monomeric moiety of Formula (I) and L is a linker). The dimeric compounds have been found to be effective in promoting apoptosis in rapidly dividing cells.

  本发明提供了公式M-L-M′的化合物（其中M和M′分别是公式（I）中的单体基团，L是连接物）。已发现二聚化合物在促进快速分裂细胞凋亡方面具有有效性。
• US8445440B2
  申请人：——

  公开号：US8445440B2

  公开（公告）日：2013-05-21
• US9834491B2
  申请人：——

  公开号：US9834491B2

  公开（公告）日：2017-12-05
• [EN] DIMERIC IAP INHIBITORS<br/>[FR] INHIBITEURS DIMÈRES D'IAP
  申请人：NOVARTIS AG

  公开号：WO2011104266A1

  公开（公告）日：2011-09-01

  The present invention provides compounds of formula M-L-M' (where M and M' are each independently a monomeric moiety of Formula (I) and L is a linker). The dimeric compounds have been found to be effective in promoting apoptosis in rapidly dividing cells.