Valylthreonine

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Valylthreonine
• 英文别名: 2-[(2-amino-3-methylbutanoyl)amino]-3-hydroxybutanoic acid
• 化学式: C₉H₁₈N₂O₄
• 分子量: 218.25
• InChiKey: GVRKWABULJAONN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.7
• 重原子数：
  15
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  113
• 氢给体数：
  4
• 氢受体数：
  5

文献信息

• SUBSTRATE FOR ASSAYING BETA-GLUCAN AND/OR ENDOTOXIN AND ASSAY METHOD
  申请人：Kitagawa Takeshi

  公开号：US20100330700A1

  公开（公告）日：2010-12-30

  An object of the present invention is to provide a peptide derivative for determining β-glucan or endotoxin which allows high sensitivity measurement, and a method for determining β-glucan and/or endotoxin using the same. The present invention relates to (1) a peptide derivative represented by the following general formula [1]: X-A 1 -Gly-Arg-A 2 -E-D  [1], (2) a reagent for determining β-glucan and/or endotoxin comprising the above-described peptide derivative, (3) a method for determining β-glucan and/or endotoxin, characterized in that a sample containing β-glucan and/or endotoxin, an amebocyte lysate of a horseshoe crab and the above-described peptide derivative are reacted each other, then the resulting released compound represented by the following general formula [2]: H-A 2 -E-D  [2] is separated from unreacted substance and quantified, and the determination is made based on this value, and (4) a reagent kit for determining β-glucan and/or endotoxin, comprising an amebocyte lysate of a horseshoe crab and the above-described peptide derivative as constituents thereof.

  本发明的目的是提供一种用于测定β-葡聚糖或内毒素的肽衍生物，该肽衍生物允许高灵敏度测量，并提供使用该肽衍生物测定β-葡聚糖和/或内毒素的方法。本发明涉及(1)由以下通式[1]表示的肽衍生物：X-A1-Gly-Arg-A2-E-D[1]，(2)用上述肽衍生物的试剂用于测定β-葡聚糖和/或内毒素，(3)一种用于测定β-葡聚糖和/或内毒素的方法，其特征在于将含有β-葡聚糖和/或内毒素的样品、一种马蹄蟹的阿米巴溶解液和上述肽衍生物反应，然后分离出代表以下通式[2]的所释放的化合物：H-A2-E-D[2]，并对此值进行定量测定，然后进行测定，以及(4)用于测定β-葡聚糖和/或内毒素的试剂盒，其包括一种马蹄蟹的阿米巴溶解液和上述肽衍生物作为其组分。
• Method for obtaining peptide fragments by use of fluorinated organic acids
  申请人：SEIKO INSTRUMENTS INC.

  公开号：EP0885899A1

  公开（公告）日：1998-12-23

  This method obtains peptide fragments having ends of specific amino acids from a protein, which does not use an enzyme and thus is associated with minimum contamination. An organic acid represented by a general formula; CF3-(CF2) n-COOH, wherein n is an integer of 0 or larger, is allowed to act on a protein or peptide.

  这种方法可以从蛋白质中获得具有特定氨基酸末端的肽片段，无需使用酶，因此污染最小。通式为 CF3-(CF2) n-COOH（其中 n 为 0 或更大的整数）的有机酸可作用于蛋白质或肽。
• SUBSTRATE FOR ASSAYING -GLUCAN AND/OR ENDOTOXIN AND ASSAY METHOD
  申请人：Wako Pure Chemical Industries, Ltd.

  公开号：EP2248821B1

  公开（公告）日：2015-01-28
• US8546072B2
  申请人：——

  公开号：US8546072B2

  公开（公告）日：2013-10-01