biselyngbyaside | 1160038-79-8

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 大环内酯类和类似物
• 英文名称: biselyngbyaside
• 英文别名: (4s,5e,8s,9e,11s,13e,15e,18r)-8-Methoxy-9,11-Dimethyl-18-[(1z,4e)-2-Methylhexa-1,4-Dien-1-Yl]-2-Oxooxacyclooctadeca-5,9,13,15-Tetraen-4-Yl 3-O-Methyl-Beta-D-Glucopyranoside；(4S,5E,8S,9E,11S,13E,15E,18R)-4-[(2R,3R,4S,5R,6R)-3,5-dihydroxy-6-(hydroxymethyl)-4-methoxyoxan-2-yl]oxy-8-methoxy-9,11-dimethyl-18-[(1Z,4E)-2-methylhexa-1,4-dienyl]-1-oxacyclooctadeca-5,9,13,15-tetraen-2-one
• CAS: 1160038-79-8
• 化学式: C₃₄H₅₂O₉
• 分子量: 604.781
• InChiKey: QLNOFWPLTFNJPW-CMAVNLJPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  43
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  124
• 氢给体数：
  3
• 氢受体数：
  9

反应信息

• 作为反应物：
  描述：

  biselyngbyaside 、 4-溴异氰酸苯酯 在 吡啶 、 乙酸酐 、 臭氧 作用下， 以 甲醇 为溶剂， 反应 2.03h， 以50%的产率得到
  参考文献：
  名称：

  Biselyngbyaside, a Macrolide Glycoside from the Marine Cyanobacterium Lyngbya sp.

  摘要：

  Bioassay-guided fractionation of the cytotoxic constituents of the marine cyanobacterium Lyngbya sp. led to the isolation of biselyngbyaside (1), a new 18-membered macrolide glycoside. The structure of I was established by spectroscopic analysis including 2D-NMR techniques and by synthetic studies. Biselyngbyaside (1) exhibits broad-spectrum cytotoxicity in a human tumor cell line panel.

  DOI：

  10.1021/ol900579k

文献信息

• Biselyngbyaside, a Macrolide Glycoside from the Marine Cyanobacterium <i>Lyngbya</i> sp.
  作者：Toshiaki Teruya、Hiroaki Sasaki、Kazuhiro Kitamura、Takeshi Nakayama、Kiyotake Suenaga

  DOI：10.1021/ol900579k

  日期：2009.6.4

  Bioassay-guided fractionation of the cytotoxic constituents of the marine cyanobacterium Lyngbya sp. led to the isolation of biselyngbyaside (1), a new 18-membered macrolide glycoside. The structure of I was established by spectroscopic analysis including 2D-NMR techniques and by synthetic studies. Biselyngbyaside (1) exhibits broad-spectrum cytotoxicity in a human tumor cell line panel.