3-(4-Hydroxyphenyl)-2-(sulfoamino)propanoic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 3-(4-Hydroxyphenyl)-2-(sulfoamino)propanoic acid
• 化学式: C₉H₁₁NO₆S
• 分子量: 261.25
• InChiKey: HFDZHKBVRYIMOG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  17
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  132
• 氢给体数：
  4
• 氢受体数：
  7

文献信息

• [EN] MODIFIED TYROSINE AMINO ACIDS, PEPTIDES CONTAINING THEM, AND THEIR USE FOR DETECTING HYDROLASE ENZYME ACTIVITY<br/>[FR] ACIDES AMINÉS DE TYPE TYROSINE MODIFIÉE, PEPTIDES LES CONTENANT ET LEUR UTILISATION POUR LA DÉTECTION DE L'ACTIVITÉ D'UNE ENZYME DE TYPE HYDROLASE
  申请人：PAMGENE BV

  公开号：WO2012159997A1

  公开（公告）日：2012-11-29

  The present invention relates to a method and tools which allow the kinetic monitoring of hydrolase enzyme activity. The present invention also aims to provide synthetic peptides and peptide residues modified such that they can be used in assays for monitoring hydrolase enzyme activity, and preferably phosphatase activity. Also claimed are modified tyrosine amino acid derivatives of formula (IV), wherein Y is chosen from -POy2- with y equal to 2 or 3 and esters thereof, -SOZ- with z equal to 2 or 3 and esters thereof, a carbohydrate or carbohydrate derivatives; and; wherein X1 and/or X2 is selected from -N3, -NO2, -CI, or -CN, -SCN, a C1 to C8 alkyl, or H, wherein either X1 or X2 is not H.

  本发明涉及一种方法和工具，允许对水解酶酶活性进行动力学监测。本发明还旨在提供合成肽和肽残基的修饰，使其可用于监测水解酶酶活性，尤其是磷酸酶活性的测定。还声明了公式(IV)中的修饰酪氨酸氨基酸衍生物，其中Y选择自-POy2-，其中y等于2或3及其酯，-SOZ-，其中z等于2或3及其酯，一种碳水化合物或碳水化合物衍生物；以及；其中X1和/或X2选自-N3，-NO2，-CI，或-CN，-SCN，C1到C8烷基，或H，其中X1或X2中的任一者不是H。
• MODIFIED TYROSINE AMINO ACIDS, PEPTIDES CONTAINING THEM, AND THEIR USE FOR DETECTING HYDROLASE ENZYME ACTIVITY
  申请人：PAMGENE B.V.

  公开号：US20140155286A1

  公开（公告）日：2014-06-05

  The present invention relates to a method and tools which allow the kinetic monitoring of hydrolase enzyme activity. The present invention also aims to provide synthetic peptides and peptide residues modified such that they can be used in assays for monitoring hydrolase enzyme activity, and preferably phosphatase activity. Also claimed are modified tyrosine amino acid derivatives of formula (IV), wherein Y is chosen from —PO y 2− with y equal to 2 or 3 and esters thereof, —SO z − with z equal to 2 or 3 and esters thereof, a carbohydrate or carbohydrate derivatives; and; wherein X 1 and/or X 2 is selected from —N 3 , —NO 2 , —CI, or —CN, —SCN, a C 1 to C 8 alkyl, or H, wherein either X 1 or X 2 is not H.

  本发明涉及一种方法和工具，可允许动力学监测水解酶酶活性。本发明还旨在提供合成的多肽和多肽残基的修饰，使它们可以用于监测水解酶酶活性，优选磷酸酶活性的测定中。还声明了公式（IV）中的修饰酪氨酸氨基酸衍生物，其中Y选择自-POy2-，其中y等于2或3及其酯，-SOz-，其中z等于2或3及其酯，一种碳水化合物或碳水化合物衍生物; 而X1和/或X2选择自-N3，-NO2，-CI或-CN，-SCN，C1至C8烷基或H，其中X1或X2中的任意一个不是H。
• Influenza vaccine and therapy
  申请人：EnGen Bio, Inc.

  公开号：US10080792B2

  公开（公告）日：2018-09-25

  The present invention is directed generally to M1 polypeptides that can be utilized as vaccines and/or antigens for generation of anti-M1 polypeptide antibodies for prophylactic treatment of individuals who are susceptible to infection by influenza virus. The anti-M1 polypeptide antibodies of the invention are useful for treatment of individuals infected with influenza virus, or useful for prophylactic treatment of individuals who are susceptible to infection by influenza virus, or for immune-suppressed individuals who cannot generate an effective antibody response.

  本发明一般涉及可用作疫苗和/或抗原的 M1 多肽，用于产生抗 M1 多肽抗体，对易受流感病毒感染的人进行预防性治疗。本发明的抗M1多肽抗体可用于治疗流感病毒感染者，或用于预防性治疗易受流感病毒感染者，或用于不能产生有效抗体反应的免疫抑制者。
• Epitope focusing by variable effective antigen surface concentration
  申请人：Distributed Bio, Inc.

  公开号：US10196427B2

  公开（公告）日：2019-02-05

  The present disclosure provides compositions and methods for the generation of an antibody or immunogenic composition, such as a vaccine, through epitope focusing by variable effective antigen surface concentration. Generally, the composition and methods of the disclosure comprise three steps: a “design process” comprising one or more in silico bioinformatics steps to select and generate a library of potential antigens for use in the immunogenic composition; a “formulation process”, comprising in vitro testing of potential antigens, using various biochemical assays, and further combining two or more antigens to generate one or more immunogenic compositions; and an “administering” step, whereby the immunogenic composition is administered to a host animal, immune cell, subject or patient. Further steps may also be included, such as the isolation and production of antibodies raised by host immune response to the immunogenic composition.

  本公开提供了通过可变有效抗原表面浓度表位聚焦生成抗体或免疫原组合物（如疫苗）的组合物和方法。一般来说，本公开的组合物和方法包括三个步骤："设计过程"，包括一个或多个硅学生物信息学步骤，以选择和生成用于免疫原组合物的潜在抗原库；"配制过程"，包括使用各种生化测定法对潜在抗原进行体外测试，并进一步结合两种或多种抗原以生成一种或多种免疫原组合物；以及 "施用 "步骤，将免疫原组合物施用到宿主动物、免疫细胞、受试者或患者身上。还可包括进一步的步骤，如分离和产生宿主对免疫原组合物的免疫反应所产生的抗体。
• Engineering pathogen resistance in plants
  申请人：The Regents of the University of California

  公开号：US10407691B2

  公开（公告）日：2019-09-10

  Provided herein are compounds and methods for increasing disease resistance and/or root length in plants.

  本文提供了用于提高植物抗病性和/或根长的化合物和方法。