Diisopropylmaleinsaeure | 929599-39-3

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: Diisopropylmaleinsaeure
• 英文别名: (Z)-2,3-di(propan-2-yl)but-2-enedioic acid
• CAS: 929599-39-3
• 化学式: C₁₀H₁₆O₄
• 分子量: 200.235
• InChiKey: LHLHWDNRHALZNF-FPLPWBNLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  74.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  Diisopropylmaleinsaeure 以 水 为溶剂， 生成 diisopropyl-maleic acid anhydride
  参考文献：
  名称：

  Cyclic anhydrides. III. Equilibrium constants for the acid-anhydride equilibrium in aqueous solutions of certain vicinal diacids

  摘要：

  DOI：

  10.1021/ja00751a040
• 作为产物：
  描述：

  diisopropyl-maleic acid anhydride 在 水 作用下， 生成 Diisopropylmaleinsaeure
  参考文献：
  名称：

  Cyclic anhydrides. III. Equilibrium constants for the acid-anhydride equilibrium in aqueous solutions of certain vicinal diacids

  摘要：

  DOI：

  10.1021/ja00751a040

文献信息

• Metallo-beta-lactamase inhibitors
  申请人：Chikauchi Ken

  公开号：US20080090825A1

  公开（公告）日：2008-04-17

  A new metallo-β-lactamase inhibitor which acts as a medicament for inhibiting the inactivation of β-lactam antibiotics and recovering anti-bacterial activities is disclosed. The maleic acid derivatives having the general formula (I) have metallo-β-lactamase inhibiting activities. It is possible to recover the anti-bacterial activities of β-lactam antibiotics against metallo-β-lactamase producing bacteria by combining the compound of the general formula (I) with β-lactam antibiotics.

  一种新的金属β-内酰胺酶抑制剂，作为一种药物用于抑制β-内酰胺类抗生素的失活并恢复抗菌活性。具有一般式（I）的马来酸衍生物具有金属β-内酰胺酶抑制活性。通过将一般式（I）的化合物与β-内酰胺类抗生素结合，可以恢复β-内酰胺酶产生细菌对β-内酰胺类抗生素的抗菌活性。
• Compositions containing oils having a specific gravity higher than the specific gravity of water
  申请人：Lapidot Noa

  公开号：US20050037087A1

  公开（公告）日：2005-02-17

  The invention relates to pharmaceutical or cosmetic compositions preferably in the form of microcapsules or microparticles which include at least one active ingredient and an oil or a mixture of oils wherein the oil or mixture of oils alone or in combination with the active ingredient have a specific gravity higher than the specific gravity of water. The invention further relates to a process for preparing said compositions.

  本发明涉及制药或化妆品组合物，优选为微胶囊或微粒形式，包括至少一种活性成分和油或油混合物，其中油或油混合物单独或与活性成分组合具有比水的比重高的特性。本发明还涉及制备该组合物的方法。
• COMPOSITIONS CONTAINING OILS HAVING A SPECIFIC GRAVITY HIGHER THAN THE SPECIFIC GRAVITY OF WATER
  申请人：LAPIDOT Noa

  公开号：US20120321685A1

  公开（公告）日：2012-12-20

  The invention relates to pharmaceutical or cosmetic compositions preferably in the form of microcapsules or microparticles which include at least one active ingredient and an oil or a mixture of oils wherein the oil or mixture of oils alone or in combination with the active ingredient have a specific gravity higher than the specific gravity of water. The invention further relates to a process for preparing said compositions.

  本发明涉及制药或化妆品组合物，优选为微胶囊或微粒形式，其中包括至少一种活性成分和一种油或混合油，其中油或混合油单独或与活性成分结合具有比水的比重大的比重。本发明还涉及制备所述组合物的方法。
• NDM INHIBITOR
  申请人：Morinaka Akihiro

  公开号：US20140221330A1

  公开（公告）日：2014-08-07

  An objective of the present invention is to provide a novel NDM (New Delhi metallo-β-lactamase) inhibitor that functions as a drug for restoring the antibacterial activity of β-lactam antibiotics that have been inactivated as a result of decomposition by NDM. According to the present invention, there is provided an NDM inhibitor contains a compound represented by general formula (I):

  本发明的目标是提供一种新型NDM（新德里金属β-内酰胺酶）抑制剂，作为一种药物，用于恢复由于NDM分解而失活的β-内酰胺类抗生素的抗菌活性。根据本发明，提供了一种包含通式（I）所表示的化合物的NDM抑制剂。
• METALLO-B-LACTAMASE INHIBITORS
  申请人：MEIJI SEIKA KAISHA, LTD.

  公开号：US20160151322A1

  公开（公告）日：2016-06-02

  A new metallo-β-lactamase inhibitor which acts as a medicament for inhibiting the inactivation of β-lactam antibiotics and recovering anti-bacterial activities is disclosed. The maleic acid derivatives having the general formula (I) have metallo-β-lactamase inhibiting activities. It is possible to recover the anti-bacterial activities of β-lactam antibiotics against metallo-β-lactamase producing bacteria by combining the compound of the general formula (I) with β-lactam antibiotics.

  揭示了一种新的金属β-内酰胺酶抑制剂，可作为药物用于抑制β-内酰胺类抗生素的失活并恢复其抗菌活性。具有通式(I)的马来酸衍生物具有金属β-内酰胺酶抑制活性。通过将通式(I)的化合物与β-内酰胺类抗生素结合，可以恢复β-内酰胺酶产生的细菌对β-内酰胺类抗生素的抗菌活性。