N-hydroxy-leucine | 1071527-53-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-hydroxy-leucine
• 英文别名: N-Hydroxy-leucin；α-Hydroxylamino-γ-methyl-butan-α-carbonsaeure；α-Hydroxylamino-isobutylessigsaeure；α-Hydroxylamino-isocapronsaeure；4-Hydroxylamino-2-methyl-pentansaeure-(5)；8-Hydroxyleucine；2-(hydroxyamino)-4-methylpentanoic acid
• CAS: 1071527-53-1
• 化学式: C₆H₁₃NO₃
• mdl: MFCD00228180
• 分子量: 147.174
• InChiKey: HJEXNFCNNXWHLC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.7
• 重原子数：
  10
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.833
• 拓扑面积：
  69.6
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 盐酸 作用下， 生成 N-hydroxy-leucine
  参考文献：
  名称：

  α-Hydroxylamino Nitriles and α-Hydroxylamino Acids^1,2

  摘要：

  DOI：

  10.1021/jo01101a007

文献信息

• Controlling protein levels in eucaryotic organisms
  申请人：Proteinix, Inc.

  公开号：US20020146843A1

  公开（公告）日：2002-10-10

  The invention relates to novel compounds comprising a ubiquitination recognition element and a protein binding element. The invention also relates to the use of said compounds for modulating the level and/or activity of a target protein. The compounds are useful for the treatment of disease such as infections, inflammatory conditions, cancer and genetic diseases. The compounds are also useful as insecticides and herbicides.

  该发明涉及包含泛素化识别元件和蛋白结合元件的新化合物。该发明还涉及利用这些化合物来调节靶蛋白的水平和/或活性。这些化合物对治疗感染、炎症状况、癌症和遗传疾病等疾病是有用的。这些化合物还可用作杀虫剂和除草剂。
• BioMolQuest: integrated database-based retrieval of protein structural and functional information
  作者：Yury V. Bukhman、Jeffrey Skolnick

  DOI：10.1093/bioinformatics/17.5.468

  日期：2001.5.1

  Motivation: Information about a particular protein or protein family is usually distributed among multiple databases and often in more than one entry in each database. Retrieval and organization of this information can be a laborious task. This task is complicated even further by the existence of alternative terms for the same concept.

  Results: The PDB, SWISS-PROT, ENZYME, and CATH databases have been imported into a combined relational database, BioMolQuest. A powerful search engine has been built using this database as a back end. The search engine achieves significant improvements in query performance by automatically utilizing cross-references between the legacy databases. The results of the queries are presented in an organized, hierarchical way.

  Availability: http://bioinformatics.danforthcenter.org/yury/public/home.html. Unavailable for commercial users.

  Contact: [e-mail]

  * To whom correspondence should be addressed.

  动机：关于特定蛋白质或蛋白质家族的信息通常分布在多个数据库中，并且在每个数据库中往往有多个条目。检索和组织这些信息可能是一项繁重的任务。这项任务更加复杂，因为存在相同概念的替代术语。

  结果：PDB、SWISS-PROT、ENZYME和CATH数据库已导入到一个组合的关系数据库BioMolQuest中。利用该数据库作为后端构建了一个强大的搜索引擎。该搜索引擎通过自动利用传统数据库之间的交叉引用，显著提高了查询性能。查询结果以有组织、分层的方式呈现。

  可用性：http://bioinformatics.danforthcenter.org/yury/public/home.html。商业用户不可用。

  联系人：[e-mail]

  * 通讯应寄送至何处。

• BIORESORBABLE POLYMERS SYNTHESIZED FROM MONOMER ANALOGS OF NATURAL METABOLITES
  申请人：Kohn Joachim B.

  公开号：US20110275782A1

  公开（公告）日：2011-11-10

  New bioresorbable polymers are synthesized from monomer analogs of natural metabolites In particular, polymers are polymerized from analogs of amino acids that contribute advantageous synthesis, processing and material properties to the polymers prepared therefrom, including particularly advantageous degradation profiles

  新的可降解生物聚合物是从天然代谢产物的单体类似物合成的。特别是，这些聚合物是从氨基酸的类似物聚合而成的，这些氨基酸有助于为所制备的聚合物提供有利的合成、加工和材料特性，包括特别有利的降解特性。
• N-DEMETHYASE GENES AND USES THEREOF
  申请人：UNIVERSITY OF IOWA RESEARCH FOUNDATION

  公开号：US20140227729A1

  公开（公告）日：2014-08-14

  The invention provides isolated nucleic acid encoding one or more gene products that allow for degradation of caffeine and related structures, and for preparation of intermediates in that catabolic pathway. Further provided are methods of using one or more of those gene products.

  本发明提供了编码一种或多种基因产物的分离核酸，该基因产物允许咖啡因及相关结构的降解，并用于该分解途径中间体的制备。此外，还提供了使用其中一种或多种基因产物的方法。
• CAFFEINE RESPONSIVE PROMOTERS AND REGULATORY GENES
  申请人：Uinversity of Iowa Research Foundation

  公开号：US20150184166A1

  公开（公告）日：2015-07-02

  The invention provides isolated N-demethylase genes and caffeine responsive proteins.

  本发明提供了分离的N-去甲基化酶基因和咖啡因响应蛋白。