ethyl α-hydrohexafluoroisobutyrate | 339-74-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: ethyl α-hydrohexafluoroisobutyrate
• 英文别名: Ethyl 3,3,3-trifluoro-2-(trifluoromethyl)propanoate
• CAS: 339-74-2
• 化学式: C₆H₆F₆O₂
• mdl: MFCD00465447
• 分子量: 224.103
• InChiKey: HOSPDBQHPFVHEZ-UHFFFAOYSA-N

物化性质

• 沸点：
  103-105 °C
• 密度：
  1.3527 g/cm3

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.833
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  ethyl α-hydrohexafluoroisobutyrate 在 五氟苯腈 、 cesium fluoride 作用下， 以 环丁砜 为溶剂， 生成 diethyl bis(trifluoromethyl)malonate
  参考文献：
  名称：

  Vlasov,V.M. et al., Journal of Organic Chemistry USSR (English Translation), 1979, vol. 15, p. 1953 - 1964

  摘要：

  DOI：
• 作为产物：
  描述：

  β-Aethoxy-heptafluor-tert-butan-β-pyrosulton 在 甲醇 作用下， 生成 ethyl α-hydrohexafluoroisobutyrate
  参考文献：
  名称：

  Fluorine-containing ?-sultones

  摘要：

  DOI：

  10.1007/bf00904039

文献信息

• Synthesis of 3,3,3-trifluoroethyl isocyanate, carbamate and ureas. Anticancer activity evaluation of N-(3,3,3-trifluoroethyl)-N′-substituted ureas
  作者：Elena L. Luzina、Anatoliy V. Popov

  DOI：10.1016/j.jfluchem.2015.06.005

  日期：2015.8

  isocyanate from perfluoroisobutene (PFIB). Isocyanate was used for synthesis of carbamates and ureas. A series of trifluoroethyl-substituted ureas has been tested in the National Cancer Institute (NCI, Bethesda, USA) by the NCI-60 DTP Human Tumor Cell Line Screening Program at a single high dose (10−5 M). The moderate anticancer activity was shown against some types of cancer on the individual human cell

  描述了一种由全氟异丁烯（PFIB）生产3,3,3-三氟乙基异氰酸酯的新方法。异氰酸酯用于合成氨基甲酸酯和脲。美国国家癌症研究所（NCI，Bethesda，USA）已通过NCI-60 DTP人肿瘤细胞系筛选计划以单一高剂量（10 -5  M）测试了一系列三氟乙基取代的脲。在白血病，非小细胞肺癌和肾癌的单个人细胞系上显示出对某些类型癌症的中等抗癌活性。
• A new approach to the synthesis of trifluoromethylated products of the [3,3]-sigmatropic rearrangement
  作者：V. G. Andreev

  DOI：10.1007/bf00698247

  日期：1994.7

  CH-acids of general formula CF3CH(X)CF3 (X = CF3, CO2R) react with 2,3-unsaturated alcohols in the presence of bases to give trifluoromethylated products of the [3,3]-sigmatropic rearrangement. These reactions provide a convenient method for the synthesis of 2-alkenyl-2-trifluoromethylmalonates.

  通式 CF3CH(X)CF3 (X = CF3, CO2R) 的 CH-酸在碱存在下与 2,3-不饱和醇反应，得到 [3,3]-σ 重排的三氟甲基化产物。这些反应为合成 2-烯基-2-三氟甲基丙二酸酯提供了一种方便的方法。
• CHARGE RETENTION MEDIUM
  申请人：Asahi Glass Company, Limited

  公开号：EP2648196A1

  公开（公告）日：2013-10-09

  To provide a charge retention medium having a surface potential at a practical level, although it is obtained from a composition containing a fluorinated copolymer having repeating units based on tetrafluoroethylene and repeating units based on ethylene. A charge retention medium (electret 30) which is obtained from a composition containing a fluorinated copolymer (A) having repeating units based on tetrafluoroethylene and repeating units based on ethylene; and at least one charge aid (B) selected from the group consisting of a compound having at least one amino group and at least one reactive functional group (excluding an amino group) and a compound having at least two amino groups and having no reactive functional group (excluding an amino group).

  提供一种电荷保持介质，尽管它是由一种含有氟化共聚物的组合物获得的，该共聚物具有以四氟乙烯为基础的重复单元和以乙烯为基础的重复单元，但它的表面电位达到实用水平。 一种电荷保持介质（驻极体 30），由含有氟化共聚物（A）的组合物获得，该共聚物具有以四氟乙烯为基础的重复单元和以乙烯为基础的重复单元；以及至少一种电荷助剂（B），该助剂选自具有至少一个氨基和至少一个反应性官能团（不包括氨基）的化合物和具有至少两个氨基且不具有反应性官能团（不包括氨基）的化合物组成的组。
• METHOD FOR PRODUCING CHARGE RETENTION MEDIUM
  申请人：Asahi Glass Company, Limited

  公开号：EP2648197A1

  公开（公告）日：2013-10-09

  To provide a process for producing a charge retention medium, with which a coating film (precursor of a charge retention medium) containing a fluorinated copolymer having repeating units based on tetrafluoroethylene and repeating units based on ethylene can easily be formed on the surface of a substrate, even in a case where the surface of the substrate has a complicated shape. A process for producing a charge retention medium (electret 30), which comprises a step of applying a coating composition containing a fluorinated copolymer (A) having repeating units based on tetrafluoroethylene and repeating units based on ethylene, and an organic solvent (C), to a substrate (first substrate 10) to form a coating film.

  提供一种电荷保持介质的生产工艺，通过该工艺，即使在基材表面形状复杂的情况下，也能容易地在基材表面形成含有氟化共聚物的涂膜（电荷保持介质的前体），该氟化共聚物具有以四氟乙烯为基础的重复单元和以乙烯为基础的重复单元。 一种电荷保持介质（驻极体 30）的生产工艺，包括将含有氟化共聚物（A）的涂层组合物（A）（A）具有基于四氟乙烯的重复单元和基于乙烯的重复单元）和有机溶剂（C）涂敷到基底（第一基底 10）上以形成涂膜的步骤。
• Amination of fluorocarbanions through arylazoperfluoroalkanes
  作者：Yu. V. Zeifman、L. T. Lantseva、I. L. Knunyants

  DOI：10.1007/bf00952928

  日期：1986.2