(2Z)-2-ethyl-3-methylbut-2-enedioic acid

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (2Z)-2-ethyl-3-methylbut-2-enedioic acid
• 英文别名: 2-ethyl-3-methylbut-2-enedioic acid
• 化学式: C₇H₁₀O₄
• 分子量: 158.15
• InChiKey: HVZKWAQLXHTHSG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  74.6
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Aspartates containing ketimine-groups and their use in coating compositions
  申请人：Bayer MaterialScience LLC

  公开号：EP1518852A1

  公开（公告）日：2005-03-30

  The present invention relates to novel aspartates, their method of production and the use of these aspartates as reactive components for polyisocyanates in two-component polyurethane coating compositions and for preparing polyurethane prepolymers. The aspartaes are prepared by first reacting a di- or polyamine with an unsaturated ester and then reacting the resultant product with a ketone.

  本发明涉及新型天冬氨酸盐，其生产方法以及将这些天冬氨酸盐作为双组分聚氨酯涂料组合物中聚异氰酸酯的反应组分和制备聚氨酯预聚物的用途。这些天冬氨酸盐是通过首先将二元或多元胺与不饱和酯反应，然后将所得产物与酮反应制备而成的。
• [EN] PHARMACEUTICAL INTERMEDIATES AND A PROCESS FOR THE PREPARATION THEREOF<br/>[FR] INTERMEDIAIRES PHARMACEUTIQUES ET PROCEDE DE PREPARATION DE CEUX-CI
  申请人：EGYT GYOGYSZERVEGYESZETI GYAR

  公开号：WO2006013399A1

  公开（公告）日：2006-02-09

  The invention relates to pure enantiomer and in certain cases new racemic-isopropanol derivatives of the general Formula (I) and a process for the preparation thereof. The partly new and partly known compounds of the general Formula (I) are useful pharmaceutical intermediates. The substituent definition of symbols R1, R2 and R3 are as stated in the patent specification.

  该发明涉及一种纯对映体，以及通式（I）的某些情况下新的消旋异丙醇衍生物，以及其制备方法。通式（I）的部分新化合物和部分已知化合物是有用的药用中间体。符号R1、R2和R3的取代定义如专利规范中所述。
• METHODS OF ADMINISTERING MONOMETHYL FUMARATE AND PRODRUGS THEREOF HAVING REDUCED SIDE EFFECTS
  申请人：XenoPort, Inc.

  公开号：US20150038499A1

  公开（公告）日：2015-02-05

  Methods of improving patient safety and reducing undesirable side effects for patients considering therapeutic treatment using monomethyl fumarate and prodrugs of monomethyl fumarate are disclosed. In particular, a method of treating a disease in a patient in need of such treatment is provided. The method comprises testing the patient for a propensity for a deficiency in tissue glutathione S-transferase theta 1 enzyme (GSTT1) levels. Thereafter, a therapeutically effective amount of a compound selected from monomethyl fumarate (MMF), a prodrug of monomethyl fumarate, and combinations thereof is administered to the patient. During the treatment of the disease, blood lymphocyte concentration is periodically tested in the patient at a predetermined time interval length that is based on the enzyme level propensity testing result.

  本发明涉及改善患者安全和减少治疗使用单甲基富马酸及其前药所产生的不良副作用的方法。具体而言，本发明提供了一种治疗患者疾病的方法。该方法包括对患者进行组织谷胱甘肽S-转移酶θ1酶（GSTT1）水平缺陷的倾向性测试。随后，向患者施用单甲基富马酸（MMF）、单甲基富马酸前药或其组合的治疗有效量。在治疗疾病期间，以基于酶水平倾向性测试结果的预定时间间隔长度定期检测患者的血淋巴细胞浓度。
• [EN] ASPARTATES USEFUL AS COMPONENTS IN COATING COMPOSITIONS AND THEIR PREPARATION<br/>[FR] ASPARTATES UTILISES COMME CONSTITUANTS DANS DES COMPOSITIONS DE REVETEMENT, ET LEUR PREPARATION
  申请人：BAYER MATERIALSCIENCE LLC

  公开号：WO2005073188A1

  公开（公告）日：2005-08-11

  The present invention relates to novel aspartates, their method of production and the use of these aspartates as reactive components for polyisocyanates in two-component polyurethane coating compositions and for preparing polyurethane prepolymers. The aspartates are prepared by first reacting a di- or polyamine with an unsaturated ester and then reacting the resultant product with a maleimide.

  本发明涉及新颖的天冬氨酸、其制备方法以及将这些天冬氨酸作为双组分聚氨酯涂料组成部分的聚异氰酸酯反应组分和制备聚氨酯预聚体。这些天冬氨酸是通过首先将二元或多元胺与不饱和酯反应，然后将产物与马来酰亚胺反应制备而成。
• Novel multi-component solventless silicone release coating composition
  申请人：GENERAL ELECTRIC COMPANY

  公开号：EP0116290A1

  公开（公告）日：1984-08-22

  The present invention provides a method for preparing a precious metal catalyzed, heat curable silicone release coating composition. Also, there is provided an article of manufacture for packaging the ingredients necessary to practice the method of the invention.

  本发明提供了一种制备贵金属催化的热固化有机硅脱模涂层组合物的方法。此外，本发明还提供了一种用于包装本发明方法所需成分的制造品。